Clinical trials
Cognitive Health clinical trials
Below are recruiting cognitive health clinical trials, each written for real people, not researchers. We’re tracking 271 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06435520RecruitingPhase 4
Helping people stop sleep medications in primary care
This trial helps people who have been using sleep medications for a long time and want to stop. You will work with your primary care doctor to gradually reduce the medication and learn ways to sleep better without pills.
Denver, ColoradoAges 21 years+ - NCT06175000RecruitingPhase 2
Maintenance obinutuzumab for central nervous system lymphoma
This trial tests whether a maintenance drug called obinutuzumab can help prevent relapse in people with primary central nervous system lymphoma (a rare lymphoma in the brain or spine) who have already responded to initial chemotherapy. It is for those who have achieved at least a partial or complete response to their first treatment.
New York, New YorkAges 18 years+ - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT05606341RecruitingPhase 1
Testing a diabetes-style shot to boost brain immunity in early Alzheimer’s
This Phase 1 study tests whether stimulating the immune system (through a receptor called TLR9) is safe and may affect brain changes in people with early Alzheimer’s. It mainly enrolls older adults with memory impairment confirmed by specific amyloid imaging.
New York, New YorkAges 60–85 - NCT06828926Recruiting
Tai Chi study for older adults with memory concerns
This study tests whether tai chi can improve thinking, memory, and overall well-being in older adults who have mild memory problems (Mild Cognitive Impairment) or are healthy. It looks at how tai chi affects the brain and daily life.
Athens, OhioAges 60 years+ - NCT05124132Enrolling by invitation
Study of resilience and brain health after an earlier parent study
This trial looks at how resilience (how well people cope with stress) and brain health change over time in older adults who already joined an earlier study. You may be eligible if you participated in that “parent study.”
St Louis, MissouriAges 65 years+ - NCT06375265Recruiting
Sleep improvement program for older surgery patients
This trial tests a digital sleep improvement program for older adults who are about to have knee or hip replacement surgery. It aims to help you sleep better before and after surgery, which may improve your brain health and recovery.
Boston, MassachusettsAges 65 years+ - NCT06938555Recruiting
Can extending nightly fasting improve sleep and thinking in breast cancer survivors?
This study tests whether eating all your meals within a shorter window each day (prolonged nightly fasting) can help improve sleep and thinking skills in breast cancer survivors who have memory or concentration problems.
Phoenix, ArizonaAges 18 years+ - NCT07408934Enrolling by invitation
Group therapy for feeling safer with psychosis
This trial tests a group therapy program called the Feeling Safe Programme for people with psychosis. It aims to help you learn new ways to cope with your symptoms and feel safer. It meets once a week for 75 minutes.
Ottawa, OntarioAges 18 years+ - NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT07222280Recruiting
Alzheimer's dementia and brain inflammation trial
This trial tests if treating brain inflammation can help older adults hospitalized with sudden confusion or cognitive issues. It may help those without a prior dementia diagnosis but who have toxic or metabolic causes for their symptoms.
Crossville, TennesseeAges 60–90 - NCT07220512Recruiting
Exercise help for ovarian, fallopian, or endometrial cancer
This trial tests a special exercise program during chemotherapy before surgery. It may help patients with certain gynecologic cancers get stronger and better prepared for treatment.
Winston-Salem, North CarolinaAges 55 years+ - NCT07106593Recruiting
Talk therapy for PTSD and tinnitus after concussion
This study tests a type of talk therapy for people with both PTSD and chronic tinnitus that started after a mild head injury. The therapy aims to help reduce symptoms of both conditions together.
San Antonio, TexasAges 18 years+ - NCT06758414Recruiting
CBT for chronic pain in veterans with serious mental illness
This trial tests a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain, designed for veterans with serious mental illness. It aims to help you manage back pain and improve your quality of life.
Baltimore, MarylandAges 18 years+ - NCT05424406Recruiting
Studying sleep timing changes in people with night-shift disorder
This study looks at how changes in your body clock (circadian timing) relate to “shift work disorder” in people who work night shifts. It may help researchers understand what drives symptoms and how to better target treatment.
Novi, MichiganAges 18 years+ - NCT05748613Recruiting
Anxiety-focused skills training for people with Alzheimer’s
This study tests a treatment aimed at reducing anxiety in people who have Alzheimer’s disease or related memory problems. It also involves a support partner, and the goal is to see whether the program can lower anxiety and stress day-to-day.
Tallahassee, FloridaAges 60 years+ - NCT04349852Recruiting
Memory and attention training for adults after brain injury
This trial tests a therapy that helps improve verbal working memory and attention in adults who had a traumatic brain injury (TBI). It may help by training thinking skills that are often affected after an injury, but it’s only for people who meet timing and mental health substance-use requirements.
New York, New YorkAges 18 years+ - NCT05079464Recruiting
Exercise plus brain stimulation to improve memory in early impairment
This trial tests whether a supervised exercise program, paired with brain stimulation, can improve thinking and memory in people with early “vascular” cognitive problems (not dementia). It may help your brain function before memory loss becomes more severe.
Toronto, OntarioAges 50 years+ - NCT05591027RecruitingPhase 1
Testing Centella asiatica for memory problems in older adults
This Phase 1 study tests whether Centella asiatica (a plant-based supplement) is safe and reaches its intended target in people with mild cognitive impairment or early Alzheimer’s disease. It also checks how it affects memory-related brain measures like MRI scans, which is why multiple scans are required.
Portland, OregonAges 60–85 - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT07603102Recruiting
Mindfulness and Walking Training for Memory After Stroke
This study tests whether combining mindfulness meditation with balance and walking exercises can help improve memory and thinking skills in people who had a stroke. The trial focuses on people with mild cognitive impairment—difficulty thinking clearly—after stroke recovery.
NanjingAges 55 years+ - NCT06709027Enrolling by invitation
Mobile health program for depression in older adults
This study is testing a smartphone-based health program designed for older adults with depression. The program aims to help you manage your mood and track changes in thinking and memory using a mobile app.
Fuzhou, FujianAges 60 years+ - NCT06684444Enrolling by invitationPhase 4
Sleep coaching study for firefighters with sleep troubles
This study tests if health coaching can help career firefighters sleep better. You'll have private coaching sessions by phone or computer.
Tucson, ArizonaAges 18 years+ - NCT07081282Recruiting
Study on frailty and thinking decline in older adults
This study looks at how to better understand and predict frailty and memory changes in older adults with at least one chronic condition. It aims to use a simple screening to personalize care and help you stay independent longer.
SingaporeAges 60–85
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Common questions
- Are there clinical trials for cognitive health?
- Yes. Clin2 currently lists 271 recruiting cognitive health studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive health trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive health trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.