Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 571 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05514106Enrolling by invitationPhase 4
MIBG heart scan study for aging and neurologic conditions
This Phase 4 study tests how an iodine-based heart scan (a special imaging test) works in people with certain neurologic diagnoses and aging-related conditions. It may help researchers better understand the heart-brain connection in these disorders and improve future care.
Rochester, MinnesotaAges 40–90 - NCT05460468Recruiting
Brain stimulation study to improve memory in aging
This study tests a brain-stimulation approach to help improve memory as people age. You may be able to take part if you can consent and meet safety and medical criteria, especially related to brain/nerve health and seizure risk.
Durham, North CarolinaAges 18–75 - NCT05457998Enrolling by invitation
Study of Alzheimer’s brain markers using memory testing
This trial looks for signs of Alzheimer’s disease in the brain by using memory and thinking tests, and related study procedures. It may help researchers find better ways to identify Alzheimer’s-related changes earlier.
Providence, Rhode IslandAges 50–80 - NCT05289258Recruiting
Barlow-style program for thinking and memory problems after breast cancer
This trial tests a structured “Barlow Protocol” program to help improve mild to moderate thinking and memory problems in people who finished breast cancer chemotherapy. It may help if your cognitive symptoms started after treatment and you’re not already in similar therapy.
CórdobaAges 18–70 - NCT05230758RecruitingPhase 3
Metformin trial for brain tumor survivors’ brain and behavior
This Phase 3 study tests whether metformin can improve brain function, behavior, and thinking in children and teens who were treated for certain brain tumors. You may be able to join if you meet age, time-since-treatment, language, and health/lab safety requirements.
New Lambton Heights, New South WalesAges 7–21 - NCT05215886Enrolling by invitation
Bariatric surgery and memory problems in people with obesity
This study looks at how bariatric (weight-loss) surgery may affect memory and thinking in people with obesity who already have memory decline or dementia. It may help doctors understand which patients benefit most and what changes to expect.
Sacramento, CaliforniaAges 18–75 - NCT05151562Recruiting
Music therapy for people with early Alzheimer’s or memory loss
This trial studies whether music therapy can improve symptoms and well-being in people with early Alzheimer’s disease or mild memory problems. You may take part in music sessions and likely be screened with MRI, so the study checks safety for scans.
Baltimore, MarylandAges 18–89 - NCT05016219Recruiting
Light therapy to improve sleep and thinking in early Alzheimer’s
This trial studies rhythmic light therapy to help people with early Alzheimer’s or mild memory problems, especially when sleep is getting worse. If you fit the sleep and vision/medical safety requirements, the study may see whether the therapy improves sleep and thinking-related symptoms.
Menands, New YorkAges 55 years+ - NCT04938349Recruiting
Dual-task training for memory and balance in older adults
This trial tests a type of training that challenges you to do two tasks at once to help with thinking and movement. It is for people over 55 who may have mild memory problems but do not have major brain, heart, or lung conditions.
Chicago, IllinoisAges 55 years+ - NCT03810794Recruiting
Acupuncture study for people with Alzheimer’s memory problems
This trial tests whether acupuncture can improve symptoms in people with Alzheimer’s disease. You may qualify if you have memory and thinking changes consistent with Alzheimer’s and meet imaging and brain-scan score requirements.
Shanghai, Shanghai MunicipalityAges 50–85 - NCT04906863Recruiting
Genetic study for early dementia in adults and families
This trial studies genes to better understand why some people develop dementia and memory problems earlier in life. It may help researchers find clearer causes and improve future testing and treatments for families affected by dementia.
New York, New YorkAges 35 years+ - NCT04804241RecruitingPhase 2
Senicapoc for early Alzheimer’s symptoms
This Phase 2 study tests whether the drug senicapoc can slow or improve symptoms in people with early Alzheimer’s disease or mild memory impairment. You would have a 50/50 chance of getting senicapoc or a placebo (inactive pill), along with regular study visits and testing.
Sacramento, CaliforniaAges 55–85 - NCT04715984Recruiting
Testing brain-circuit targets during DBS surgery in Parkinson’s
This study looks at how brain connections involved in movement may relate to thinking and memory problems in Parkinson’s disease. It happens during a deep brain stimulation (DBS) operation, using tests while the surgeon is placing an electrode.
Nashville, TennesseeAges 40 years+ - NCT04396873RecruitingPhase 1
PET brain scan study of inflammation markers in neurodegeneration
This Phase 1 study tests a PET scan to measure inflammation-related changes in the brain using a medication called ketoprofen. It may help researchers understand which people with certain brain diseases could benefit from treatments aimed at inflammation.
Bethesda, MarylandAges 18–99 - NCT04482660Enrolling by invitation
PET brain scan study of tau protein in ALFA volunteers
This study uses a special PET brain scan tracer to measure “tau” protein clumps in the brain. It’s meant to better understand brain changes in people who are already part of the ALFA research program, and may help researchers connect tau levels with memory and thinking.
Barcelona, BarcelonaAges 45 years+ - NCT04262206RecruitingPhase 4
Testing how statins affect outcomes in adults 75 and older
This trial studies whether cholesterol-lowering medicine (a statin, specifically atorvastatin) improves health and benefits in people age 75 and older in everyday life. It may help doctors understand which older adults benefit most and how to use these medicines safely.
Birmingham, AlabamaAges 75 years+ - NCT04239079Recruiting
Study of immune-related changes in Parkinson’s and Alzheimer’s
This study looks for “autoimmune-like” (immune-system) features in brain-related diseases such as Parkinson’s and Alzheimer’s, using genetic testing and other assessments. Results may help researchers understand what drives these conditions and who might be more likely to have immune-related changes.
New York, New YorkAges 55–90 - NCT04240561Recruiting
Study of hearing aid results in people with Alzheimer’s dementia
This study looks at how much hearing aid outcomes vary in older adults who have Alzheimer’s dementia or mild memory problems. It may help researchers understand what hearing aids work best and for whom.
Chicago, IllinoisAges 50–90 - NCT04124029Recruiting
How head injuries affect brain health
This study looks at how mild or moderate head injuries (concussions) may relate to brain conditions like chronic traumatic encephalopathy (CTE) and Alzheimer's disease. By comparing people with and without head injuries, researchers hope to learn more about what causes brain changes over time.
Boston, MassachusettsAges 30–90 - NCT03687710Enrolling by invitation
Alzheimer’s registry for people with memory concerns or risk
This is a research registry that helps doctors compare how different memory and Alzheimer’s risk groups change over time. It may help researchers learn which people are more likely to develop Alzheimer’s and how to better track early changes.
New York, New YorkAges 18–99 - NCT03618186Enrolling by invitationPhase 2
Brain scan study for African Americans age 30+
This Phase 2 study uses brain imaging (including PET and MRI) to learn more about brain changes. It may help researchers improve how brain patterns are measured and understood, which could guide future care.
Jacksonville, FloridaAges 30 years+ - NCT03574207Recruiting
Brain stimulation study for memory in certain adults
This study tests a targeted, non-surgical brain stimulation method to help people with memory, especially remembering facts over time. It compares healthy adults and adults with amnestic mild cognitive impairment (aMCI), using sessions plus brain scans and memory testing.
Omaha, NebraskaAges 19 years+ - NCT03370224Enrolling by invitation
Story memory training for older adults
This study tests a memory-skills training approach (the Modified Story Memory Technique) to help older adults with aging-related memory changes. You may be asked to do memory exercises, and some people may also complete an optional brain MRI scan.
East Hanover, New JerseyAges 65 years+ - NCT03101722Enrolling by invitation
Huperzine A for hearing loss, tinnitus, and mild memory issues
This trial tests whether huperzine A can improve hearing-related symptoms along with tinnitus (ringing) and mild cognitive (memory/thinking) problems. If you have mild-to-moderate hearing loss plus bothersome constant tinnitus and some cognitive decline, this study may help researchers see if the treatment makes a difference.
Shanghai, Shanghai MunicipalityAges 60 years+
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Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 571 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.