Cognitive clinical trials

Testing speech and memory checks at home for early thinking problems

This study uses a video-based system at home to check your speech and memory, helping doctors spot thinking problems early using artificial intelligence. The goal is to see if this simple, at-home test can reliably catch early memory and thinking changes.

Brain Stimulation to Improve Memory in Older Adults

This study tests whether a non-invasive brain stimulation technique (tDCS) can help improve memory and thinking skills in people aged 60–75 who have noticed mild memory problems. You'll receive either real or sham (placebo) stimulation and undergo cognitive training over several weeks.

Brain Stimulation for Memory Problems in Older Adults

This study tests a new, non-invasive brain stimulation technique called transcranial temporal interference stimulation to see if it can improve memory and thinking skills in older adults with mild cognitive impairment (early memory loss that isn't yet dementia). Participants will receive the stimulation treatment and have their cognitive function monitored over time.

Balance and thinking training for Parkinson's

This study tests if combining balance and walking exercises with thinking tasks can improve movement and daily life in people with Parkinson's disease. It is for those in early to moderate stages who can participate in physical and cognitive training.

Nutritional supplement for memory decline in older adults

This trial tests whether a nutritional supplement can help slow or improve memory loss in older adults who have mild cognitive decline (noticeable changes in thinking skills that are not yet dementia). You will take a daily supplement and attend regular check-ups.

Early cognitive rehab for moderate brain injury recovery

This trial tests whether starting cognitive rehabilitation early after a moderate traumatic brain injury helps improve thinking, memory, and daily function. If you're an adult with a moderate brain injury who is medically stable, this study may help you regain skills faster.

Study of a headband device for cognitive health check

This study tests a new way to check cognitive (thinking and memory) health using a simple headband that measures electrical signals on your scalp. It is looking for people 65 to 90 years old, with or without memory concerns, and a family member or friend who can also take part.

Remote brain health clinic for mild memory problems

This study tests a remote 'brain health clinic' for people with mild memory or thinking problems (mild cognitive impairment). It aims to help diagnose the cause of memory issues from home, so you don't need to travel to a clinic.

Computer training for attention and memory after COVID

This study tests whether computer-based exercises can improve attention and working memory in adults who still have cognitive (thinking) complaints after COVID. It may help if your focus and memory issues have lasted for a while.

Testing long-lasting cognitive training for older veterans

This study looks at whether a cognitive training program you’ve already completed can keep helping over time, and whether it can be improved with “booster” sessions. It may help older veterans maintain thinking and daily functioning skills after earlier training.

Online cognitive tests you can do remotely

This study checks how well an online remote testing approach measures thinking and memory. It may help researchers collect cognitive data more easily, especially by combining it with other related studies.

Brain and memory testing in fatty liver disease

This study checks how well your brain and memory work in people with non-alcoholic fatty liver disease. It also looks at brain function with special assessments, which may help researchers understand what changes happen with this condition.

Brain and hearing training for older cochlear-implant users

This trial studies whether a structured auditory (hearing) and cognitive (thinking) training program can improve outcomes for adults who use cochlear implants. It’s designed for people at a certain stage after their implant and with specific hearing and thinking test results.

Preventing Memory and Thinking Decline With Multidomain Program

This study tests a multi-part program (not just one activity) to help slow down memory and thinking decline in older adults at higher risk. You would complete brief thinking tests and follow the study’s coaching/intervention schedule to see if it helps over time.

Track thinking skills in children over time

This study follows children’s thinking and learning over time using simple testing at school. It aims to better estimate how children’s thinking develops and how it changes as they grow.

Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment

PET scan study for Alzheimer's or mild cognitive impairment

This study uses a special PET scan to look at a brain protein called PDE4 in people with Alzheimer's disease or mild cognitive impairment. It may help researchers understand how this protein is involved in memory and thinking problems.

Lifestyle program for weight and chronic low back pain

This trial studies whether a lifestyle change program (often diet and activity habits) can reduce long-lasting low back pain in overweight or obese adults. It also aims to see if people can keep their usual care while adding the lifestyle program.

Primary care program for mood and thinking in early Alzheimer’s

This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.

Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community

Combining brain training with ketamine for depression

This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.

Brain stimulation to improve memory and balance in older adults

This study tests a non-invasive brain stimulation technique called temporal interference stimulation to see if it can improve memory and balance during daily activities in older adults with mild cognitive impairment. The goal is to find a safe, drug-free way to support brain health.

Comparing two talk therapies for anxiety and PTSD

This trial tests two types of therapy — metacognitive therapy and cognitive-behavioral therapy — to see which works better for people with certain anxiety disorders or PTSD. You would be randomly assigned to one of the treatments and attend regular sessions.

Virtual reality for needle fear in teens

This trial tests if using augmented reality or virtual reality during talk therapy helps teenagers ages 11 to 17 who are afraid of needles. The goal is to see if these technologies can make therapy more effective and less scary.