Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,511 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06813898RecruitingEarly Phase 1
A New Scan for Early Prostate Cancer Recurrence
This study tests a new scanning method (rhPSMA-7.3 PET/CT) to detect prostate cancer recurrence when PSA is slightly high. If your PSA is low but rising, and standard scans haven't found cancer, this scan might help locate it.
Chicago, IllinoisAges Any age - NCT06812052RecruitingPhase 1
Short course radiation before surgery for retroperitoneal sarcoma
This study tests whether a short course of radiation before surgery can treat retroperitoneal sarcoma (a rare cancer in the back of the belly). It is for people whose tumor is removable and who have not had previous radiation in the same area.
Boston, MassachusettsAges 18 years+ - NCT06809673Enrolling by invitation
Blood markers in head and neck cancer surgery
This study looks at whether certain blood tests can help predict how head and neck cancer will respond to treatment. If you are planning surgery for squamous cell cancer of the throat, voice box, or mouth, this trial may offer more information about your outlook.
GenoaAges 18 years+ - NCT06813235Recruiting
Sleep improvement program for Chinese cancer survivors
This study tests a step-by-step program to help Chinese cancer survivors with mild to moderate sleep problems. The program adjusts to your needs and aims to improve your sleep without strong medication.
Hong KongAges 18 years+ - NCT06807619RecruitingPhase 1
Sotorasib for people with brain tumors needing surgery
This study tests a drug called sotorasib in people with brain tumors who are already scheduled for surgery or a biopsy. It may help find out if the drug can reach and treat the tumor.
Basking Ridge, New JerseyAges 18 years+ - NCT06807086Recruiting
Online talk therapy for insomnia in cancer survivors
This study tests if online therapy sessions can help cancer survivors with long-term sleep problems (insomnia). It is for people who have finished or are still in active cancer treatment, including those with stable metastatic cancer.
Boston, MassachusettsAges Any age - NCT06797336RecruitingPhase 1
Study of PT0253 for advanced solid tumors with KRAS G12D mutation
This trial tests a new drug called PT0253 for people with advanced solid tumors that have a specific genetic change (KRAS G12D). The drug aims to target and slow down the growth of cancer cells with this mutation.
Los Angeles, CaliforniaAges 18 years+ - NCT06800196RecruitingPhase 1
Study of KNT-0916 for advanced solid tumors with FGFR2 changes
This study tests a new drug, KNT-0916, for people with advanced solid tumors that have a specific change in the FGFR2 gene. It may be an option if other treatments haven't worked or aren't available.
Guangzhou, GuangdongAges 18–75 - NCT06797999RecruitingPhase 1/Phase 2
Study of ADCE-D01 for soft tissue sarcoma
This trial tests a new drug called ADCE-D01 for people with soft tissue sarcoma that has spread or cannot be removed by surgery. The goal is to see if it is safe and effective.
Aurora, ColoradoAges 18 years+ - NCT06798207RecruitingPhase 2
TQB2102 for advanced gynecologic cancers with HER2
This trial tests a new targeted drug, TQB2102, for women with advanced or recurrent gynecologic cancers that have some HER2 protein. It may be an option if your cancer has continued to grow after platinum chemotherapy.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06802835RecruitingPhase 1/Phase 2
EGFR antibody plus immunotherapy and chemo for advanced nasopharyngeal cancer
This trial tests a combination of an EGFR antibody, a PD-1 inhibitor, and chemotherapy for people with nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this new mix can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06794125Recruiting
Higher radiation dose for chest tumors
This trial tests if giving a higher dose of radiation to tumors in the chest (lungs or nearby areas) can better control symptoms or prevent them from getting worse. It is for people who need palliative radiation—treatment aimed at easing discomfort or slowing tumor growth, not curing the cancer.
Kelowna, British ColumbiaAges 18 years+ - NCT06798922RecruitingPhase 3
Flap-sparing radiation for mouth cancer after reconstructive surgery
This trial tests a special radiation technique for people who have had reconstructive surgery for oral cavity cancer. The goal is to see if we can spare the flap (the rebuilt tissue) from high radiation doses to improve healing and quality of life.
AmiensAges 18 years+ - NCT06024824RecruitingPhase 1/Phase 2
Radiation therapy for pancreatic cancer before surgery
This trial tests a special type of radiation therapy for people with pancreatic cancer who are going to have chemotherapy and then surgery. The radiation is 'painted' to give more dose to the tumor and less to nearby healthy tissue.
DublinAges 18 years+ - NCT06784752RecruitingPhase 3
Testing a targeted radiation therapy for advanced neuroendocrine tumors
This trial tests a radioactive drug called [177Lu]Lu-DOTA-TATE for people with advanced neuroendocrine tumors (GEP-NET) that have grown or spread. The drug targets tumor cells that have a specific receptor (SSTR) and delivers radiation directly to them, aiming to slow or shrink the tumors while limiting damage to healthy tissue.
Scottsdale, ArizonaAges 12–100 - NCT06788990RecruitingPhase 2/Phase 3
Study of ficerafusp alfa with pembrolizumab for advanced head and neck cancer
This study tests a new drug called ficerafusp alfa (BCA101) combined with the immunotherapy pembrolizumab for people with advanced head and neck cancer that has not been treated before. The goal is to see if adding ficerafusp alfa helps shrink tumors better than pembrolizumab alone.
Birmingham, AlabamaAges 18 years+ - NCT06790602RecruitingPhase 2
Cemiplimab plus gemcitabine for metastatic pancreatic cancer
This trial tests a combination of an immunotherapy drug (cemiplimab) and chemotherapy (gemcitabine) for people with pancreatic cancer that has spread to other parts of the body. It is for those whose tumors have specific genetic changes (in the SWI/SNF genes) and have only had one prior treatment that was not immunotherapy.
La Jolla, CaliforniaAges 18 years+ - NCT06681818Recruiting
New method to measure liver regrowth after surgery
This study tests a new way to measure how well your liver grows back and heals after part of it is removed. The goal is to predict and prevent complications after surgery.
Englewood, New JerseyAges 18 years+ - NCT05217693RecruitingPhase 1
First study drug BB-1705 for advanced solid tumors
This Phase 1 trial tests BB-1705 in people with advanced or metastatic (spread) solid tumors that cannot be removed with surgery. It mainly focuses on safety and how the drug behaves in the body, and may offer an option for patients when standard treatments have not worked.
BeijingAges 18–78 - NCT06062823RecruitingPhase 2
Newer EGFR pill for advanced lung cancer with specific mutations
This trial tests a newer type of EGFR targeted therapy pill for people with advanced non-small cell lung cancer who have not had prior treatment and whose cancer has a specific genetic change called a PACC mutation. The goal is to see if the drug works well for this group.
SingaporeAges 21–99 - NCT06277154RecruitingPhase 2
MASCT-I plus chemo for first-line advanced soft tissue sarcoma
This trial tests a new immune cell therapy (MASCT-I) combined with standard chemotherapy (doxorubicin and ifosfamide) for people with advanced soft tissue sarcoma who have not had prior chemotherapy or targeted therapy. The goal is to see if the combination works better than chemo alone.
GuangzhouAges 18–70 - NCT06780670RecruitingPhase 2/Phase 3
Comparing a new treatment to standard care for advanced prostate cancer
This study tests a new drug (AAA817) against the usual treatments for men with advanced prostate cancer that has stopped responding to a type of targeted radiation therapy (Lu-PSMA). The goal is to see if the new drug can slow the cancer's growth better than standard options.
Scottsdale, ArizonaAges 18–100 - NCT06781567RecruitingPhase 2
HG146 for advanced adenoid cystic carcinoma
This trial tests a new drug called HG146 for people with advanced adenoid cystic carcinoma that has progressed despite previous treatments. The goal is to see if HG146 can slow or stop the cancer from growing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06760819RecruitingPhase 2
Sevacertinib for solid tumors with HER2 mutations
This study tests an oral tablet called sevacertinib in people with solid tumors (not lung cancer) that have a HER2 mutation. It aims to see how well the drug works and how safe it is for people who have tried other treatments or have no good options left.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,511 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.