Clinical trials
Colorectal Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting colorectal cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,511 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06197776Recruiting
Predicting treatment success for advanced nasopharyngeal cancer
This study uses advanced testing (multi-omics) to predict if combining chemoradiation with immunotherapy works better for nasopharyngeal cancer that has returned or spread. It aims to find the right treatment for each person.
Guangzhou, GuangdongAges 18–70 - NCT06161974RecruitingPhase 2
Olutasidenib and temozolomide for IDH1-mutant high-grade glioma
This trial tests a combination of two oral medications, olutasidenib and temozolomide, for people with a specific type of aggressive brain tumor (high-grade glioma) that has an IDH1 mutation. The goal is to see if this combination can help control the tumor after standard treatment like radiation.
Aurora, ColoradoAges 12–39 - NCT06156800Recruiting
Radiation before biopsy in advanced cancer
This trial tests whether it is safe and effective to start radiation therapy before getting a tissue biopsy for patients with advanced or metastatic cancer that needs urgent treatment. It aims to avoid delays in care while still allowing for a biopsy later.
London, OntarioAges 18 years+ - NCT06162377RecruitingPhase 4
Methylnaltrexone before surgery for mouth cancer
This trial tests if taking methylnaltrexone for two weeks before surgery can help people with mouth cancer. It is a small, early study to see how the drug affects the tumor and the body.
Houston, TexasAges 18 years+ - NCT06163820RecruitingPhase 1/Phase 2
Bevacizumab and immunotherapy with radiation for melanoma brain metastases
This trial tests a combination of a drug that stops blood vessel growth (bevacizumab), immunotherapy, and focused radiation to treat melanoma that has spread to the brain and is causing symptoms. The goal is to see if this approach shrinks tumors and improves outcomes.
Melbourne, VictoriaAges 18 years+ - NCT03019471Recruiting
Test for cancer using a noninvasive sample
This trial studies a noninvasive test to look for signs of cancer in people newly diagnosed with certain cancers. It aims to see whether the test can help detect or identify cancer before treatment starts.
Maastricht, LimburgAges 18 years+ - NCT06141070RecruitingPhase 3
Adding high-dose radiation to standard treatment for advanced lung cancer
This trial tests whether adding a high, focused dose of radiation to the usual first treatment (chemo and/or immunotherapy) can help people with non-small cell lung cancer that has spread to a limited number of spots (up to 5). The goal is to see if this approach improves how well the treatment works.
GothenburgAges 18 years+ - NCT06136884RecruitingPhase 1
Study of AO-252 for advanced solid tumors with or without brain metastases
This trial tests an experimental oral pill (AO-252) that targets a protein called TACC3 in advanced solid tumors, including those that have spread to the brain. It is for people whose cancer has a specific genetic change (TP53 mutation) or who have prostate cancer, and who have already tried other treatments.
Detroit, MichiganAges 18 years+ - NCT06146231Recruiting
Breast reconstruction with Motiva implants and fat grafting
This study tests a new breast reconstruction method using Motiva Flora implants and your own fat to rebuild the breast after a mastectomy. It is for women who need tissue expansion as part of their reconstruction and have completed cancer treatments at least one year earlier.
GhentAges 18 years+ - NCT06139107RecruitingPhase 1
Radiation and abemaciclib plus letrozole before breast cancer surgery
This trial combines a short course of radiation before surgery with two oral medications (abemaciclib and letrozole) to treat early-stage, hormone-sensitive breast cancer. The goal is to see if this approach can shrink the tumor and improve outcomes.
Belleville, New JerseyAges 60 years+ - NCT06144606RecruitingPhase 2
KTE-X19 CAR T for MRD+ B-ALL
This trial tests a CAR T-cell therapy called KTE-X19 for people with B-cell ALL that is in remission but still has trace disease (MRD-positive). The goal is to see if this treatment can eliminate the remaining cancer cells and prevent relapse.
Tampa, FloridaAges 18 years+ - NCT06134375RecruitingPhase 1/Phase 2
TM plus capecitabine for triple-negative breast cancer
This trial tests a drug called tetrathiomolybdate (TM) combined with capecitabine for people with triple-negative breast cancer who still have cancer cells after standard chemotherapy and surgery. The goal is to see if this combination can help prevent the cancer from coming back.
Indianapolis, IndianaAges 18–80 - NCT05931393RecruitingPhase 2
Cabozantinib retreatment after it helped, in kidney cancer study
This Phase 2 study tests a “next-step” cabozantinib strategy for advanced kidney cancer (RCC) after your cancer previously responded to cabozantinib and then progressed. It aims to see if re-using cabozantinib in a planned sequence can control the cancer again with manageable side effects.
Dallas, TexasAges 18 years+ - NCT06123754RecruitingPhase 3
Envafolimab plus chemo for stage III NSCLC before surgery
This trial tests a new immunotherapy (Envafolimab) combined with standard chemotherapy before and after surgery for stage III non-small cell lung cancer that can be removed. The goal is to see if adding Envafolimab helps shrink the tumor and improve outcomes compared to chemotherapy alone.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06125743Recruiting
Self-management program for head and neck swelling
This study tests a self-management program to help people with head and neck cancer manage swelling (lymphedema) and tightness (fibrosis) after treatment. It may be a good fit if you have finished cancer therapy, are cancer-free, and have access to internet at home.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06127784Recruiting
Survivorship program for head and neck cancer follow-up
This trial tests a new program to help people who finished treatment for head and neck cancer stay on track with follow-up care. You may be able to join if you completed treatment 3 to 6 months ago and your cancer has not spread.
London, OntarioAges 18 years+ - NCT06111313RecruitingPhase 2
Prostate cancer trial testing targeted radiation with hormone therapy
This trial tests a new radiation approach for prostate cancer that has not spread. It combines different types of radiation with or without hormone therapy to see if this approach works better with fewer side effects.
Miami, FloridaAges 35–85 - NCT06084338RecruitingPhase 2
Focused Radiation Therapy Without Hormone Therapy for Advanced Prostate Cancer
This trial tests whether giving focused radiation to many cancer spots (SBRT) can work without using testosterone-blocking hormone therapy. It is for men whose prostate cancer has spread and is no longer responding to low testosterone, and who have already tried one of the newer hormone drugs.
West Los Angeles, CaliforniaAges 18 years+ - NCT06097156Recruiting
Automated blood test for breast cancer monitoring
This trial tests an automated device that prepares blood samples to detect cancer-related changes. It aims to improve how doctors monitor breast cancer that has spread, without needing a tissue biopsy every time.
MilanAges 18 years+ - NCT06081920RecruitingPhase 2
IBI363 for advanced melanoma after standard treatment
This study tests a new drug called IBI363 for people with advanced melanoma that has progressed after standard treatment. It aims to see if IBI363 can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06083896RecruitingPhase 1
Pelvic bone cancer treatment with light-activated nails
This trial tests a new way to treat cancer that has spread to the pelvic bone. It uses a special nail that is activated by light to help stabilize the bone and reduce pain, while also improving your ability to move around after surgery.
Houston, TexasAges 18 years+ - NCT06083883RecruitingPhase 1
NK cell therapy targeting NY-ESO-1 for sarcomas
This trial tests a new kind of immune therapy using your own natural killer (NK) cells that are specially trained to find and attack cancer cells that have the NY-ESO-1 target. It is for people with certain sarcomas or other advanced solid tumors that have not responded to prior treatments.
Houston, TexasAges 16–80 - NCT06101069Recruiting
New MRI scan to tell tumor from radiation damage
This study tests a special MRI technique to better distinguish between tumor regrowth and radiation-related changes in people with brain tumors. If you've had radiation for a brain tumor and now have suspicious changes, this scan might help guide your next steps.
Cleveland, OhioAges 18–60 - NCT06086704RecruitingPhase 2
PET/MRI scan for PR-positive breast cancer before surgery
This trial tests a new PET/MRI scan (using a special tracer called 18F-FFNP) to see how it images progesterone-receptor-positive breast cancer before surgery. You would get the scan and then have your planned surgery.
Madison, WisconsinAges 18 years+
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Common questions
- Are there clinical trials for colorectal cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,511 recruiting colorectal cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced Colorectal Cancer
- Lung Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- Metastatic Colorectal Cancer
- Locally Advanced Rectal Cancer
- Metastatic Colorectal Cancer (CRC)
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.