Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 901 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05592886Recruiting
Oral probiotic-and-prebiotic drink to prevent colon polyps returning
This study tests whether an oral synbiotic (a probiotic plus a prebiotic) can reduce the chance that advanced colon growths come back after they were removed. It also looks at changes in stool-related bacterial “gene markers” that may signal lower risk over time.
Hohhot, Inner MongoliaAges 18–90 - NCT05642819Recruiting
MRI before and after surgery for abdominal cancers
This study uses extra detailed MRI scans before and/or around planned abdominal surgery to help researchers understand changes in the body. It includes people having surgery for certain cancers and some people having surgery for non-cancer (benign) conditions.
EdinburghAges 18 years+ - NCT06911970Recruiting
Exercise and immune response in cancer treatment
This trial tests whether aerobic exercise can help your immune system fight cancer better during chemotherapy or immunotherapy. It is for people with breast or colon cancer that has not spread to other parts of the body.
Sherbrooke, QuebecAges 40–70 - NCT07108517Recruiting
Post-traumatic growth program for cancer survivors in Greece
This trial tests a guided program to help people with breast, colorectal, or head and neck cancer find personal growth after finishing chemotherapy. It is for those who have completed their planned treatment within the last 5 years and are not currently in other psychological care.
ThessalonikiAges 18–80 - NCT07223424RecruitingPhase 2
Patient preference study: shot vs infusion for immunotherapy
This study compares two ways to take immunotherapy drugs (nivolumab or pembrolizumab): as a shot under the skin (subcutaneous) versus an infusion into a vein (intravenous). It looks at which method patients prefer and is for people with certain advanced cancers where these drugs are already approved.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05652348Recruiting
Predicting outcomes after heated chemotherapy for stomach or colon spread
This study tries to better predict how well patients do after heated chemotherapy placed in the abdomen during surgery for stomach or colon cancer that has spread to the lining of the abdomen. It may help doctors choose the best treatment plan and timing for future patients.
BerlinAges 18 years+ - NCT06402864RecruitingPhase 3
Internal radiation for rectal preservation in intermediate rectal cancer
This study is testing whether a special internal radiation treatment (contact X-ray brachytherapy) can help people with intermediate-stage rectal cancer avoid surgery and keep their rectum intact. It is for patients who are also receiving mFolfirinox chemotherapy.
Avignon, FranceAges 18–99 - NCT05402696Recruiting
Study of advanced surgery care for colorectal tumors
This study follows adults who are referred for treatment of a specific type of colorectal tumor that involves the left side of the colon. It aims to improve care and outcomes for people needing advanced surgery.
Saint Cloud, MinnesotaAges 18 years+ - NCT06308354Recruiting
Colorectal cancer data study at Xijing Hospital
This study collects and reviews medical records from patients diagnosed with colorectal adenocarcinoma at Xijing Hospital between 2013 and 2023. The goal is to build a dataset for future research—no new treatments or procedures are being tested.
Xi'an, ShaanxiAges 18–100 - NCT06843434RecruitingPhase 2
Study of two immunotherapy drugs for rectal cancer
This trial tests a combination of two immunotherapy drugs, botensilimab and balstilimab, for people with newly diagnosed rectal adenocarcinoma that has not spread. The goal is to see if this treatment can shrink the tumor before surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT05912075RecruitingPhase 1
New pre-surgery radiation plus ASTX660 for rectal cancer
This early-phase trial tests adding ASTX660 (a new drug) to pre-surgery radiation for locally advanced rectal cancer. It aims to improve control of the tumor before surgery, making it more likely that the surgeon can remove it with clear margins.
Lyon, RhöneAges 18 years+ - NCT05176483RecruitingPhase 1
New drug combinations for advanced solid tumors
This trial tests a new drug called zanzalintinib, which may slow or shrink various types of advanced cancer. It is given together with other cancer treatments, and the study is looking at many different cancers including kidney, prostate, bladder, lung, liver, and more.
Phoenix, ArizonaAges 18 years+ - NCT05438563Recruiting
MRI-guided prostate cancer ablation with ultrasound from the urethra
This trial tests a newer way to treat certain low- to intermediate-risk prostate cancers using MRI guidance and an ultrasound probe placed through the urethra. It aims to destroy the tumor while using imaging to help target it more precisely.
Rochester, MinnesotaAges 45–80 - NCT04074720Recruiting
Collecting breast cancer tissue and blood samples
This study collects tissue and/or blood samples from people with breast cancer to help future research. It may be useful if you’re already having surgery or another procedure as part of your treatment plan.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04722341Recruiting
Time-limited eating for people with certain breast or rectal cancers
This study tests whether eating only within a shorter daily time window can improve cancer outcomes in people with specific breast or rectal cancers. It also looks at how this affects the body (such as metabolism) and who is most likely to benefit.
Birmingham, AlabamaAges 18 years+ - NCT05411718RecruitingPhase 2
Aspirin or naproxen to prevent cancer in Lynch syndrome
This trial tests whether daily aspirin or naproxen can “intercept” (stop) cancer from starting or coming back in people with Lynch syndrome who are currently cancer-free. Participants are randomly assigned to one of the two drugs, and neither the participant nor the team knows which one you’re taking.
Houston, TexasAges 18 years+ - NCT06708429Recruiting
Lynch syndrome and gut immune system study
This study looks at how the immune system interacts with the gut lining in people with Lynch syndrome and those without. It may help us better understand how Lynch syndrome affects the body.
Monrovia, CaliforniaAges 18 years+ - NCT07095517RecruitingPhase 1
Preventing early-onset colorectal tumors with tirzepatide
This study tests if tirzepatide can help prevent early-onset colorectal tumors in people aged 18-50 who have had certain types of polyps removed. It aims to find risk factors and ways to stop colorectal cancer before it starts.
Boston, MassachusettsAges 18–50 - NCT07221058RecruitingPhase 1
Adaptive radiation boost study for rectal cancer
This study tests whether giving an extra, targeted radiation dose (adaptive radiation boost) after standard treatment can improve outcomes for people with rectal cancer. You may be eligible if you have stage T2-3 N0-1 rectal cancer and can undergo MRI scans and certain chemotherapies.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07198945Enrolling by invitation
6 vs 12 month follow-up after large colon polyp removal
This trial compares whether a follow-up colonoscopy at 6 or 12 months is better for people who have had a large polyp (20-50 mm) removed. It will help doctors understand the best timing for surveillance.
Birmingham, AlabamaAges 18 years+ - NCT07050485Enrolling by invitation
Postbiotic gummies after GI cancer surgery
This trial tests if taking postbiotic gummies (a type of supplement that helps good gut bacteria) can help your gut recover faster after surgery for stomach, colon, or other gastrointestinal cancers. It is for people having scheduled, minimally invasive (laparoscopic) surgery to remove their cancer.
Tampa, FloridaAges 18 years+ - NCT06458998Enrolling by invitation
Improving cancer screening for veterans
This study looks at ways to help veterans get screened for liver cancer (hepatocellular carcinoma) and colorectal cancer. The goal is to see if certain programs or tools can make it easier for veterans to complete these important cancer screenings.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06750094RecruitingPhase 3
Study of amivantamab plus FOLFIRI in colorectal cancer
This trial tests adding amivantamab to standard FOLFIRI chemotherapy for people with certain types of colorectal cancer that have already been treated once. It aims to see if this combination works better than another common treatment (cetuximab or bevacizumab plus FOLFIRI).
Chandler, ArizonaAges 18 years+ - NCT05496491Recruiting
Before-surgery radiation and chemo for rectal cancer
This study tests a specific “before surgery” treatment (radiation plus chemotherapy), followed by more chemotherapy to improve outcomes in people with certain types of rectal cancer. You might be considered if your cancer is locally advanced but not spread to distant organs.
LarissaAges 18–80
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 901 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.