Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 867 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04936581Recruiting
Quality of life after rectal cancer surgery
This study looks at patient-reported outcomes—how you feel and function—after surgery for rectal cancer. It may help doctors better understand recovery and well-being after different surgical approaches and treatments.
MadridAges 18–100 - NCT06226857RecruitingPhase 3
Anti-EGFR for left-sided, RAS wild-type metastatic colorectal cancer
This trial tests whether anti-EGFR therapy works better for people with left-sided colorectal cancer that has spread, whose tumors do not have certain gene mutations (RAS wild-type). It is for those who have not yet had treatment for metastatic disease.
MoscowAges 18–99 - NCT06279299Recruiting
Lymph node removal for rectal neuroendocrine tumors during laparoscopic surgery
This trial tests whether removing lymph nodes in the pelvis during laparoscopic surgery for rectal neuroendocrine tumors (a type of slow-growing or aggressive tumor) improves outcomes. It is for people with larger or recurrent tumors, or those at higher risk due to tumor grade or depth.
Beijing, Beijing MunicipalityAges 18–75 - NCT03659448RecruitingPhase 3
Test drug that helps map colon and rectal cancer during surgery
This Phase 3 study tests SGM-101, a drug used during surgery to help doctors better outline primary, recurrent, and spread (metastatic) colorectal cancer. It may improve how completely tumors are identified and removed during an operation.
Duarte, CaliforniaAges 18 years+ - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT07802197Recruiting
Radiation before surgery for advanced rectal cancer
This trial compares giving radiation therapy before surgery versus going straight to surgery for people with advanced rectal cancer that has not spread to other parts of the body. It aims to see which approach may be better for controlling the cancer.
IstanbulAges 18 years+ - NCT07802002Recruiting
Dietary supplement to prevent bowel injury during radiation for rectal cancer
This trial tests whether a special dietary supplement can help protect the rectum from radiation damage during chemoradiation for locally advanced rectal cancer. If it works, it may reduce painful bowel symptoms like frequent stools and cramping.
Guangzhou, GuangdongAges 18–75 - NCT06512480Recruiting
Robotic colorectal surgery with the Hugo RAS platform
This trial is testing a new robotic system (Hugo RAS) for planned colorectal surgeries, such as for colon or rectal cancer or diverticulosis. It aims to see how well the robot works alongside enhanced recovery programs to help you heal faster.
Elche, AlicanteAges 18 years+ - NCT05939687RecruitingPhase 3
Mesh placement to help prevent complications after bowel surgery
This Phase 3 trial tests whether placing a protective mesh during stoma closure can lower the risk of complications after low anterior resection surgery. It may help people heal more safely and reduce stoma-related problems.
MoscowAges 18–85 - NCT06157463Recruiting
FAPI imaging for newly diagnosed rectal cancer
This trial tests a new imaging agent called 68Ga-FAPI to see how well it finds rectal cancer and guides treatment. It's for people with new stage II or III rectal cancer who are about to start neoadjuvant therapy (treatment before surgery).
TaoyuanAges 18 years+ - NCT06576986Recruiting
Can a supplement prevent mouth sores during chemo?
This trial tests whether a special supplement (synbiotic) can prevent mouth sores caused by chemotherapy in people with colorectal cancer. It's for those starting treatment who live in or near Belo Horizonte, Brazil.
Belo Horizonte, Minas GeraisAges 18 years+ - NCT07750951RecruitingPhase 2
Combination therapy before surgery for advanced rectal cancer
This trial tests a combination of two immunotherapy drugs and chemotherapy given before surgery for a type of rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to shrink the tumor and improve the chances of successful surgery.
Xi'an, ShaanxiAges 18 years+ - NCT06220058Recruiting
Preventing hernias after emergency colorectal surgery
This study compares two ways of closing the belly after emergency colorectal surgery to see which one better prevents hernias. If you need this type of surgery, you may be able to join.
Girona, CataloniaAges 18 years+ - NCT06220045Recruiting
Comparing two meshes for closing abdominal incisions in urgent colon surgery
This trial tests two different mesh types used to close the midline incision after urgent colorectal surgery, to see which one better prevents hernias and wound infections.
GironaAges 18 years+ - NCT02246634Recruiting
MRI screening to find liver metastases in bowel cancer
This study checks whether a special MRI scan (DW-MRI) can spot liver metastases early in people with high-risk colorectal cancer. Finding metastases sooner may help doctors choose the right treatment path.
Macclesfield, CheshireAges 16 years+ - NCT06631443Recruiting
Asian Watch-and-Wait Study for Rectal Cancer
This study is for people with rectal cancer who have had treatment like radiation or chemo and their tumor has disappeared or nearly disappeared. Instead of surgery right away, doctors will closely monitor the cancer with regular check-ups to make sure it stays gone.
Mumbai, MaharashtraAges 18 years+ - NCT05677269Recruiting
Compare surgery for bowel endometriosis versus IVF pathway
This trial studies whether surgically removing colorectal (bowel) endometriosis works better and is more cost-effective than choosing an IVF/ICSI treatment plan. It’s for people who want to get pregnant and are deciding between surgery and fertility treatments.
EindhovenAges 21–40 - NCT05933122Recruiting
Sexual health support after rectal cancer surgery
This study looks at how common sexual difficulties are in women after rectal cancer surgery, and whether a sexologist-led support program can help. If you qualify, you may be asked about sexual well-being and take part in counseling support.
Brive-la-GaillardeAges 18 years+ - NCT07589205RecruitingPhase 1
Testing IBI3028 for Advanced Solid Tumors
This early-stage trial tests a new drug called IBI3028 in people with advanced cancers that cannot be removed by surgery or have spread. The study aims to find the right dose and understand how the drug works in your body.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT05601505RecruitingPhase 2
DNA blood test–guided treatment before rectal cancer surgery
This trial uses a special DNA blood test (circulating tumor DNA) to help guide chemotherapy and radiation before surgery for locally advanced rectal cancer. It aims to improve outcomes by tailoring treatment based on the DNA signals from the tumor.
Beijing, Beijing MunicipalityAges 18–75 - NCT07535112RecruitingPhase 1
Study of a new drug for advanced colorectal cancer with KRAS G12D mutation
This trial tests an experimental drug (BAY 3771249) for people with advanced or metastatic colorectal cancer that has a specific genetic change called KRAS G12D. The goal is to see if the drug is safe and if it can help shrink tumors.
Phoenix, ArizonaAges 18 years+ - NCT05793554Recruiting
AI checks cancer type during rectal surgery in real time
This study tests an AI system that helps identify cancer or polyp findings during rectal surgery or assessment, using real-time information. It may help surgeons classify tissue more accurately while you are already getting treatment.
Dublin, IrelandAges 18 years+ - NCT06620627Recruiting
Blood test for early cancer detection before colonoscopy
This study is testing a new blood test that might help find cancer early. If you are 40 or older and planning a routine screening colonoscopy, you may be able to join. You will give a blood sample before the colonoscopy, and the researchers will see if the test can detect signs of cancer.
Austin, TexasAges 40 years+ - NCT06805045Recruiting
Image-guided surgery for rectal cancer
This trial uses special imaging to guide surgery for rectal cancer. It studies whether detailed scans taken before surgery can help doctors remove the cancer more precisely.
BolognaAges 18–80
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 867 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.