Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 866 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04949646Recruiting
Nerve monitoring during rectal cancer surgery
This trial studies whether checking pelvic nerve signals during rectal cancer surgery (total mesorectal excision) is helpful. It may help surgeons avoid nerve injury while removing the cancer.
LarissaAges 18–90 - NCT06523634Recruiting
SBRT for rising PSA after prostate removal
This trial tests a precise type of radiation (called SBRT) to the prostate bed for men whose PSA starts rising after prostate removal surgery. It aims to see if this targeted approach can effectively treat the recurrence without needing long-term hormone therapy.
AalstAges 18 years+ - NCT06496958Recruiting
Better colonoscopy with water, CO2, and a belly compression belt
This study tests a new approach to make colonoscopy easier and more comfortable by using water, carbon dioxide gas, and a soft belly compression device instead of the standard air. The goal is to help patients need less manual pushing from the doctor during the procedure.
Kaohsiung CityAges 45–80 - NCT06321536RecruitingPhase 2
Testing microbiota therapy for resistant bacteria in the gut
This study tests a treatment made from healthy donor stool (called microbiota therapy) given as an enema or through a feeding tube. It aims to help people who carry resistant bacteria that are hard to treat, by reducing or clearing those bacteria from the gut.
Atlanta, GeorgiaAges 18 years+ - NCT06303622Recruiting
Comparing two MRI-guided biopsy methods for prostate cancer
This trial compares two ways to guide a prostate biopsy using MRI images, to see which better detects clinically significant prostate cancer in men with suspicious MRI findings.
Hong KongAges 18 years+ - NCT06302595Recruiting
MRI-guided prostate biopsy for cancer diagnosis
This trial uses MRI to guide a biopsy of the prostate, aiming to better detect cancer in men with abnormal PSA levels, a lump, or a suspicious MRI finding.
Boston, MassachusettsAges 30 years+ - NCT06131840RecruitingPhase 1
Study of SGN-CEACAM5C for advanced solid tumors
This trial tests a new drug called SGN-CEACAM5C in people with advanced solid tumors that have not responded to other treatments. The drug targets a protein on cancer cells to try to stop them from growing.
Phoenix, ArizonaAges 18 years+ - NCT06111313RecruitingPhase 2
Prostate cancer trial testing targeted radiation with hormone therapy
This trial tests a new radiation approach for prostate cancer that has not spread. It combines different types of radiation with or without hormone therapy to see if this approach works better with fewer side effects.
Miami, FloridaAges 35–85 - NCT05792722Recruiting
Testing a prostate-sparing bladder surgery for bladder cancer
This trial studies whether a “prostate-sparing” radical cystectomy is safe and effective for bladder cancer patients who are having surgery. It aims to see if this approach can treat bladder cancer while reducing prostate-related side effects.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06018961Recruiting
Study of bowel slowdown after digestive surgery
This study is looking at how common and severe a condition called 'postoperative ileus' (temporary slowdown of the bowel) is after planned digestive tract surgeries. It will help doctors better understand and manage this complication.
ToulouseAges 18 years+ - NCT05864196RecruitingPhase 1
Testing two-shot prostate radiation with MRI-guided planning
This early-phase study tests a prostate radiation approach given in two treatments, planned using MRI. It’s designed for men with lower-to-intermediate risk prostate cancer and aims to see if this method is safe and works well.
Mineola, New YorkAges 18 years+ - NCT05822895Recruiting
Testing a real-time computer to help find colon polyps
This study checks whether a computer tool helps doctors find colon polyps during routine colonoscopy. If the tool improves detection, it could help find growths earlier and guide safer follow-up.
Singapore, SingaporeAges 21–90 - NCT05710861Recruiting
Focal HIFU versus prostate surgery: cost and quality of life
This trial compares focal HIFU (a targeted heating treatment inside the prostate) with prostate surgery, looking at overall cost and quality of life. It may help people with certain early, limited prostate cancers understand which option fits best for them.
BesançonAges 50–75 - NCT05546827RecruitingPhase 2
Pre-surgery radiation plus immunotherapy for mucosal melanoma
This Phase 2 trial tests giving radiation and immunotherapy before surgery for mucosal melanoma in the nose/sinuses or rectum. It may help shrink the tumor and improve outcomes while aiming to control the disease locally and in nearby areas.
Houston, TexasAges 18 years+ - NCT05346796Recruiting
Online care plan program for colon or rectal cancer survivors
This trial tests whether a survivorship (after-treatment) health plan delivered through an online health record helps people after colon or rectal cancer treatment. It may help you organize follow-up care and stay on track with recommendations.
Indianapolis, IndianaAges 18–99 - NCT05334485RecruitingPhase 2/Phase 3
Pyridostigmine to treat slow bowel recovery after colorectal surgery
This trial tests whether pyridostigmine helps return bowel function faster after colorectal surgery when the gut is “stuck,” causing bloating and no gas or stool. It also checks safety and side effects compared with standard care.
Cleveland, OhioAges 18 years+ - NCT05080673Recruiting
Colonoscopy planning for small, noncancerous colon polyps
This trial tests whether people with 1–2 small, noncancerous colon polyps should get their next colonoscopy after 5 years or after 10 years. It may help reduce unnecessary procedures or find cancers earlier if the shorter interval is safer for you.
Fairbanks, AlaskaAges 45–70 - NCT05133024RecruitingPhase 2
Beetroot juice to help prevent bowel slowdown after colon surgery
This Phase 2 study tests whether drinking beetroot juice can reduce “postoperative ileus,” when the intestines temporarily don’t move normally after colorectal surgery. If it works, it may help you recover bowel function sooner after an elective laparoscopic colon and upper rectum operation.
EdegemAges 18 years+ - NCT04797039Recruiting
MRI-guided freezing treatment for localized prostate cancer
This trial studies a treatment where doctors use MRI pictures to guide freezing of a prostate tumor. It may help men with smaller, well-placed prostate cancers who cannot or do not want surgery or radiation right now.
Rochester, MinnesotaAges 30–100 - NCT04567771Recruiting
Proton vs IMRT radiation after surgery for uterine or cervical cancer
This study compares two types of radiation therapy (proton and IMRT) given after surgery for endometrial or cervical cancer. It aims to see which treatment is better at reducing side effects while still being effective.
Scottsdale, ArizonaAges 18 years+ - NCT04359069Recruiting
Shorter urinary catheter time after pelvic surgery
This study looks at whether the urinary (Foley) catheter can stay in place for a shorter time after certain pelvic operations. It aims to see if timing of catheter removal is safer and more comfortable, especially for bladder function.
Los Angeles, CaliforniaAges 18 years+ - NCT03862781Recruiting
Quicker bowel recovery after minimally invasive right colon surgery
This study looks at whether a specific internal stitch connection (an anastomosis) helps your bowel start working sooner and may help you leave the hospital earlier after right colon surgery. It’s mainly for adults having planned, minimally invasive right hemicolectomy.
Grand Rapids, MichiganAges 18 years+ - NCT03842007Recruiting
Study of constipation symptoms and how bowel function works
This study looks at how normal bowel movements work, and what goes wrong in people with long-term constipation. It may help researchers better understand constipation causes, which can guide future treatments.
Rochester, MinnesotaAges 18–80 - NCT02871726Recruiting
Robot-assisted ultrasound biopsy of the prostate
This trial tests a robot-assisted method to take prostate tissue samples using an ultrasound probe placed through the rectum. It may help patients and doctors get clearer biopsy results when there are early warning signs of prostate problems, before a cancer diagnosis is confirmed.
Baltimore, MarylandAges 45–75
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 866 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.