Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04221893Recruiting
Radiation therapy for metastatic gastrointestinal cancers
This trial tests whether adding radiation therapy to your current immunotherapy can help control cancer that has spread in the digestive system. It aims to improve symptoms and possibly slow the cancer's growth.
San Francisco, CaliforniaAges 18 years+ - NCT06307548RecruitingPhase 1/Phase 2
Image-guided surgery and light therapy for colorectal cancer
This trial tests a special dye that helps surgeons see tumors more clearly during surgery, followed by a light therapy to destroy any remaining cancer cells. It is for people with advanced or returning colorectal cancer who are already scheduled for surgery.
Buffalo, New YorkAges 18 years+ - NCT07829081Recruiting
Watch-and-wait after immunotherapy for early-stage GI cancers
This study looks at whether some patients with early-stage stomach, colon, or rectal cancers that are mismatch repair-deficient (a genetic feature making them more likely to respond to immunotherapy) can safely avoid surgery and instead be monitored closely after treatment with immunotherapy. It aims to confirm if this watch-and-wait approach is as effective and helps patients avoid major operations.
BaselAges 18 years+ - NCT07764497RecruitingPhase 2
Chemotherapy through liver artery for colorectal cancer that spread to liver
This trial tests giving chemotherapy directly into the liver artery for people whose colorectal cancer has spread only to the liver and cannot be surgically removed. The goal is to shrink the tumors and make the liver healthy enough for surgery.
Toronto, OntarioAges 18 years+ - NCT06452745Recruiting
Early colon cancer detection using a blood test
This study uses a simple blood test to find early signs of colorectal cancer in people who already had a positive stool test. If it works, it could help avoid unnecessary colonoscopies in the future.
Reus, TarragonaAges 50–70 - NCT07705139Recruiting
Listening to bowel sounds after colorectal surgery
This study listens to your bowel sounds after colorectal cancer surgery to see if they can help doctors know when your gut is working again. You will have a small device placed on your belly to record sounds for a few days.
Wuhan, HubeiAges 18–90 - NCT07621757Enrolling by invitation
Genetic Risk Testing for Colorectal Cancer Screening
This study looks at how genetic risk information can help decide who needs colorectal cancer screening and when. Researchers want to see if testing for genetic risk factors improves screening decisions for people who haven't had a colonoscopy before.
Evanston, IllinoisAges 45–75 - NCT06637215Recruiting
Day surgery for colorectal cancer
This study tests whether a same-day surgery approach for colorectal cancer is safe and effective. It uses small incisions and special pain management to help you recover faster at home with a caregiver nearby.
Shenyang, LiaoningAges 18–75 - NCT07589517RecruitingPhase 1/Phase 2
CAR-NK Cell Therapy for Advanced Colorectal Cancer
This trial tests a new type of immune cell therapy (CAR-NK cells) designed to fight advanced colorectal cancer that has spread or cannot be surgically removed. The therapy is customized to target specific protein markers on your cancer cells.
Shenzhen, GuangdongAges 18–75 - NCT07551596RecruitingPhase 2
Two immunotherapy drugs for colorectal cancer with residual disease
This trial tests a combination of two immunotherapy drugs to see if they can stop colorectal cancer from returning after standard treatment. It is for people who still have cancer DNA in their blood after surgery and/or chemotherapy, which means they are at high risk of the cancer coming back.
New Orleans, LouisianaAges 18 years+ - NCT06522919RecruitingPhase 2
Immunotherapy and chemotherapy for advanced colorectal cancer
This trial tests a sequence of treatments for people with a specific type of advanced colorectal cancer (called pMMR or MSS) that has not responded to earlier therapies. Patients first receive an immunotherapy combination (pembrolizumab plus a personalized dendritic cell vaccine) followed by a chemotherapy pill (trifluridine/tipiracil) plus bevacizumab. The goal is to see if this sequence can help control the cancer.
Meldola, Forlì CesenaAges 18 years+ - NCT07405476RecruitingPhase 2
Zanidatamab before surgery for HER2 positive colon or rectal cancer
This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.
Atlanta, GeorgiaAges 18 years+ - NCT07388953Recruiting
Nerve block for better pain relief after colon surgery
This study tests adding a special nerve block (peripheral autonomic block) to a standard abdominal wall block to see if it provides better pain relief after minimally invasive left-sided colon surgery. It may help patients experience less pain and use fewer pain medications.
Belo Horizonte, Minas GeraisAges 18–80 - NCT07328087RecruitingEarly Phase 1
Personalized colon cancer vaccine trial for MSS stage 3 patients
This trial tests a custom-made vaccine designed from your tumor's genetic material. The vaccine is given alongside standard chemotherapy and an immunotherapy drug to try to prevent the cancer from coming back. It is for people with stage 3 colorectal cancer that has been fully removed by surgery and has certain high-risk features.
ThessalonikiAges Any age - NCT07271355RecruitingPhase 3
Pressurized chemo spray for appendix or colorectal cancer spread in abdomen
This trial tests a new way to deliver chemotherapy directly into the abdomen as a pressurized spray, using a drug called mitomycin. It is for people with appendix or colorectal cancer that has spread to the lining of the abdomen and cannot be removed by surgery.
Goodyear, ArizonaAges 18 years+ - NCT07066046Recruiting
AI-assisted colonoscopy for finding colorectal lesions
This trial tests whether artificial intelligence can help doctors better detect and classify growths in the colon during a colonoscopy. You may benefit from potentially more accurate results.
São Paulo, São PauloAges 18 years+ - NCT06958926Recruiting
Study of colon cancer that returns after surgery
This study looks at colon cancer that comes back in the same area after surgery. It may help doctors understand how to better treat this type of recurrence.
HsinchuAges 18 years+ - NCT07050394RecruitingEarly Phase 1
Experimental drug for advanced colorectal cancer
This trial tests a new experimental drug (HNF4α srRNA) given through a vein for people with advanced colorectal cancer that has not responded to or cannot be treated with standard therapies. The goal is to see if this treatment can help shrink or slow the growth of the cancer.
Shanghai, None SelectedAges 18 years+ - NCT06995924Recruiting
Improving follow-up care for colorectal cancer survivors
This study tests whether a navigator and online education can help colorectal cancer survivors get the recommended follow-up tests after surgery. If you've had surgery for stage I-III colorectal cancer in the last 3 months, this program may support you in staying on track with your surveillance.
Seattle, WashingtonAges 18 years+ - NCT06957626Recruiting
Predicting polyp return after removal
This study aims to develop a tool using gut bacteria and metabolites to predict if high-risk colon polyps will come back after removal. If you are between 40 and 75 and have had certain types of colon polyps removed, you may be able to help us build better prediction methods.
BeijingAges 40–75 - NCT06864338Recruiting
Pilot study for a new colorectal cancer screening test
This study tests a new stool-based test for detecting colorectal cancer and advanced polyps. It aims to see how well it works compared to a colonoscopy. The results may lead to a simpler screening option.
Morrisville, North CarolinaAges 18 years+ - NCT06827366Recruiting
Lifestyle study for people at high risk of colorectal cancer
This study tests a lifestyle program for people who are at high risk for colorectal cancer but have not been diagnosed. The goal is to see if healthy changes can help lower your risk over one year.
Lyon, FranceAges 35–74 - NCT05592886Recruiting
Oral probiotic-and-prebiotic drink to prevent colon polyps returning
This study tests whether an oral synbiotic (a probiotic plus a prebiotic) can reduce the chance that advanced colon growths come back after they were removed. It also looks at changes in stool-related bacterial “gene markers” that may signal lower risk over time.
Hohhot, Inner MongoliaAges 18–90 - NCT06710314Enrolling by invitation
Metabolic syndrome and recovery after colorectal cancer surgery
This trial studies how metabolic syndrome (a mix of high blood pressure, diabetes, and other factors) changes after colorectal cancer surgery. It aims to understand why some people's metabolic syndrome gets better after their tumor is removed, which could lead to better treatments.
Chongqing, Chongqing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,202 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.