Clinical trials
Combination Therapy clinical trials
Below are recruiting combination therapy clinical trials, each written for real people, not researchers. We’re tracking 898 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06516445RecruitingPhase 2
Short radiation plus targeted drugs before surgery for rectal cancer
This trial tests a new combination of treatments before surgery for locally advanced rectal cancer. You would receive short-course radiation, then an immunotherapy drug (camrelizumab) plus a PARP inhibitor (fluzoparib) and chemotherapy, to shrink the tumor and make surgery more successful.
Wuhan, HubeiAges 18–75 - NCT06838910RecruitingPhase 2
Tislelizumab and anlotinib for thymus cancer after first treatment
This study tests a combination of two drugs (tislelizumab and anlotinib) as a second treatment option for people with thymoma or thymic carcinoma whose cancer has worsened after first-line therapy. It aims to see if this combination can control the tumor and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT06878222RecruitingPhase 2
Testing an immunotherapy combo before surgery for cervical cancer
This trial tests whether combining two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemotherapy (paclitaxel and cisplatin) before surgery can help shrink cervical cancer. It is for people with certain stages of cervical cancer who are candidates for surgery, including those who want to preserve their fertility.
ShanghaiAges 18–75 - NCT06966934Recruiting
Nasal airway and oxygen for stomach scope in obesity
This trial tests whether a breathing tube placed in the nose (nasopharyngeal airway) combined with high-flow oxygen can improve safety during painless gastroscopy in people with obesity. It may help you breathe better while sedated.
NanjingAges 18 years+ - NCT02885753RecruitingPhase 3
Liver-only metastatic colon cancer trial using targeted chemo
This Phase 3 trial tests different ways to deliver chemotherapy for colon cancer that has spread only to the liver (with limited possible tiny lung spots). It looks at whether the treatment plan improves outcomes compared with another chemotherapy approach, using oxaliplatin and LV5FU2 (with or without irinotecan) plus an added targeted medicine.
BrusselsAges 18 years+ - NCT07410975RecruitingPhase 2
Immunotherapy and chemo before surgery for lung cancer
This trial tests combining two immunotherapy drugs (anti-CTLA-4 antibody and sintilimab) with chemotherapy before surgery for stage II-III non-small cell lung cancer. The goal is to see if this approach helps shrink tumors and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07443956Recruiting
Biologic and anti-obesity drug combo for psoriatic arthritis
This study tests whether adding a weight-loss medication (tirzepatide) to a biologic (ixekizumab) helps people with psoriatic arthritis and overweight or obesity. You will need to have biopsies of joint tissue and fat to see how the treatment affects inflammation.
Birmingham, EnglandAges 18–75 - NCT07492615RecruitingPhase 2
Sintilimab plus chemo vs. chemo alone for stomach cancer after surgery
This trial tests whether adding the immunotherapy drug Sintilimab to standard chemotherapy after surgery can help prevent stomach or gastroesophageal junction cancer from coming back. It's for people with high-risk or advanced stage cancer that has a specific genetic feature (dMMR or MSI-H).
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07495397Recruiting
Daphnetin plus chemo for advanced ovarian cancer maintenance
This trial is testing a combination of two drugs—daphnetin capsules and a standard chemotherapy (TC regimen)—as a targeted maintenance therapy after initial surgery for advanced ovarian cancer. The goal is to see if this treatment can help keep the cancer from coming back.
Changchun, JilinAges 18–75 - NCT07667751RecruitingPhase 2
Study of Ipalotinib with Sunitinib and Olaparib before surgery for advanced ovarian cancer
This trial tests a combination of three drugs (Ipalotinib, Sunitinib, and Olaparib) given before surgery to shrink tumors in people with a specific type of advanced ovarian cancer that has a genetic marker called HRD-positive. The goal is to see if this treatment helps make surgery more effective.
HefeiAges 18–75 - NCT06359444Recruiting
Exercise therapy for fatty liver disease
This study tests whether a high-intensity exercise program can improve liver function and insulin sensitivity in people with MASLD (a type of fatty liver disease). It may help you if you are looking for a non-drug way to manage your condition.
GhentAges 18–75 - NCT07454720RecruitingPhase 2/Phase 3
Study of Adebrelimab with SHR-8068 and chemoradiation before surgery for rectal cancer
This trial tests whether adding two immunotherapy drugs (adebrelimab and SHR-8068) to standard chemoradiation before surgery can improve outcomes for adults with locally advanced rectal cancer that can be surgically removed.
Wuhan, HubeiAges 18–75 - NCT06304350RecruitingPhase 2
Pembrolizumab plus chemo before surgery for esophageal cancer
This trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (given before surgery) can help shrink stage II/III esophageal cancer. The goal is to make surgery more likely to remove all cancer and improve outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06460636Recruiting
Water therapy and relaxation for fibromyalgia pain
This trial tests if combining relaxation exercises with water therapy can help reduce fibromyalgia pain and symptoms. It is for women aged 20 to 39 who are married and have a confirmed fibromyalgia diagnosis.
Rahim Yar Khan, Punjab ProvinceAges 20–39 - NCT06002789RecruitingPhase 2
PD-1 immunotherapy with or without chemo before surgery for colorectal cancer
This trial tests a medicine called PD-1 (a type of immunotherapy that helps your immune system fight cancer), sometimes with chemotherapy, before surgery for a certain type of colorectal cancer. It is for people whose tumors have a specific DNA repair problem (dMMR or MSI-H) and whose cancer has not spread to distant organs.
Guangzhou, GuangdongAges 18–80 - NCT05861830RecruitingPhase 3
Dalpiciclib plus hormone therapy after CDK4/6 treatment
This trial tests dalpiciclib together with hormone (endocrine) therapy in people with HR-positive, HER2-negative advanced breast cancer whose cancer has already responded poorly to a prior CDK4/6 inhibitor. It aims to see if this combination can better control the cancer after that earlier treatment has failed.
Beijing, Beijing MunicipalityAges 18–80 - NCT06931054Recruiting
Acupuncture, ear acupressure and nicotine patches for quitting smoking
This trial tests whether adding acupuncture and ear acupressure to nicotine replacement therapy helps people quit smoking. If you smoke at least 10 cigarettes a day, are 18 or older, and can read Chinese, you may be eligible.
Hong KongAges 18 years+ - NCT07443826RecruitingPhase 1/Phase 2
Gene therapy for age-related muscle loss and heart health
This trial tests a gene therapy that may help rebuild muscle and improve blood vessel growth in people ages 35 to 75. It's designed for those with stable health conditions and no history of cancer, heart disease, blood clots, or diabetes.
Coxen Hole, Bay IslandsAges 35–75 - NCT07147426RecruitingPhase 2
Tislelizumab plus chemo before surgery for head and neck cancer
This trial tests whether giving the immunotherapy drug tislelizumab with chemotherapy before surgery can help people with advanced head and neck cancer. The goal is to shrink the tumor enough to remove it completely during surgery.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06841159RecruitingPhase 2
Personalized radiation plus immunotherapy and chemo for metastatic colorectal cancer
This trial tests a new combination of ultra-precise radiation therapy, immunotherapy, chemotherapy, and targeted therapy for people with metastatic colorectal cancer that has a normal DNA mismatch repair system. The goal is to see if this personalized approach can better control the cancer and improve outcomes.
ShanghaiAges 18–75 - NCT06594796Recruiting
Lifestyle program for back pain and weight
This trial tests a combined exercise and lifestyle program for people with long-lasting low back pain who are overweight or have obesity. The program is delivered by physical therapists and aims to improve physical function and reduce pain.
AmsterdamAges 18 years+ - NCT07014462Enrolling by invitationPhase 1
Venetoclax and dexamethasone for untreated AML
This trial tests a combination of two oral medicines (venetoclax and dexamethasone) for people with newly diagnosed AML who cannot have or choose not to have high-dose chemotherapy. The goal is to see if this gentler treatment is safe and tolerable.
Burlington, VermontAges 18 years+ - NCT07750951RecruitingPhase 2
Combination therapy before surgery for advanced rectal cancer
This trial tests a combination of two immunotherapy drugs and chemotherapy given before surgery for a type of rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to shrink the tumor and improve the chances of successful surgery.
Xi'an, ShaanxiAges 18 years+ - NCT06775275RecruitingPhase 2
Testing adebrelimab plus chemo before lung cancer surgery
This trial tests a new drug (adebrelimab) combined with standard chemotherapy, with or without another drug (bevacizumab), given before surgery for people with a certain type of lung cancer. The goal is to see if this combination helps shrink the tumor and makes surgery more effective.
GuangzhouAges 18–65
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Common questions
- Are there clinical trials for combination therapy?
- Yes. Clin2 currently lists 898 recruiting combination therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a combination therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a combination therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.