Clinical trials
Critical Illness clinical trials
Below are recruiting critical illness clinical trials, each written for real people, not researchers. We’re tracking 352 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07653659Recruiting
Lowering norepinephrine in shock: effects on blood vessel pressure
This study tests whether reducing the dose of a medicine that raises blood pressure (norepinephrine) affects how blood moves through the body in people with distributive shock. If you are on a steady low dose of norepinephrine and have a special heart monitor (PiCCO catheter), this trial may help doctors understand safer ways to wean the medicine.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07390786Recruiting
Family support program after ICU stay
This study tests a collaborative care program for family members of ICU recovery patients, designed to improve mental health support after a loved one's hospitalization.
Charleston, South CarolinaAges 18 years+ - NCT07307066Recruiting
Ventilation feedback study for lung protection in ARDS
This study tests a computer system that gives real-time breathing machine advice to help protect the lungs of patients with severe lung injury (ARDS). It may help doctors adjust the ventilator settings to cause less damage.
Qujing, YunnanAges 18–75 - NCT07093125Recruiting
Rehabilitation for ICU patients on a breathing machine
This trial is studying rehabilitation practices for people in the ICU who need a breathing machine (ventilator) for at least 48 hours. It aims to improve recovery and care for critically ill patients.
Genova, ItalyAges 16–100 - NCT05513456Recruiting
ICU doctors and trainees answer a fast online case survey
This study asks intensive care doctors (including trainees) to respond to short ICU case scenarios in a randomized survey. It aims to see whether people’s answers differ by gender and ethnicity, which could help improve fairness and education in ICU decision-making.
StockholmAges Any age - NCT06269900RecruitingPhase 3
Dexamethasone for Severe Hospital-Acquired Pneumonia with Inflammation
This trial tests whether adding the anti-inflammatory drug dexamethasone to standard antibiotics improves recovery from severe hospital-acquired pneumonia in critically ill patients on a ventilator.
AmiensAges 18–85 - NCT05279547Recruiting
Bed-cycle exercise study to test muscle oxygen during ICU care
This trial tests whether brief “interval” bed-cycling changes how well your leg muscles use oxygen compared with steady cycling. It’s meant for carefully selected ICU patients who can safely do active cycling while on ventilator support.
LeuvenAges 18 years+ - NCT05409573Recruiting
Check oxygen monitoring during pre-intubation in the ICU
This study tests whether a specific oxygen level monitor (end-tidal oxygen, or EtO2) can be used during “preoxygenation” before breathing tube placement. It may help clinicians intubate more safely for people who urgently need a breathing tube due to serious breathing failure.
OrléansAges 18 years+ - NCT04094428Recruiting
Study of ICU outcomes, deaths, and care costs
This study looks at what happens to people in intensive care, including deaths and hospital resource use. It may help hospitals plan better care and understand the costs of staying in the ICU.
UlmAges Any age - NCT01913938Recruiting
Testing treatment for severe inflammation in very ill adults
This trial looks at how to treat a severe, whole-body immune overreaction (“hemophagocytosis”) in adults who are critically ill. You might be considered if blood counts are low (white blood cells and platelets) and if you are already receiving a growth-factor medicine (rhG-CSF).
UlmAges 18–90 - NCT06843668RecruitingPhase 2/Phase 3
Best ways to give colistin for tough infections in the ICU
This study tests different ways of giving the antibiotic colistin to patients in the ICU with infections that are hard to treat. The goal is to find the best dosing schedule to help you fight the infection more effectively.
BuraidahAges 18 years+ - NCT06683781Recruiting
Breathing machine settings and weaning success study
This study looks at how breathing machine settings and monitoring can help predict if a patient will successfully come off the ventilator. It may help doctors choose better settings for patients who are ready to try breathing on their own.
Buenos AiresAges 18–100 - NCT06391424Recruiting
Oxygen use and breathing effort during ventilator weaning
If you are on a breathing machine in the ICU and ready to try breathing on your own, this study looks at how much oxygen your body uses during that test. It may help doctors better understand when you are ready to come off the ventilator.
Leiden, South HollandAges 18 years+ - NCT06150326Recruiting
Medical honey for wound treatment in intensive care
This trial tests whether medical honey can help heal wounds like bedsores, cuts, or surgical openings in intensive care patients. If you have a fresh wound that meets the size requirements, you may be able to join.
AngersAges 18 years+ - NCT05671614Recruiting
Prevent muscle stem cell failure after critical illness
This trial studies ways to improve recovery of skeletal muscle in people who have been very sick in the ICU. It focuses on preventing problems with the body’s muscle “repair cells” after critical illness.
Prague, Czech RepublicAges 18 years+ - NCT05298982Enrolling by invitation
Join a long-term follow-up study for ICU care
This study follows people who joined the TEAM Phase III trial to learn how ICU care affects health over the long term. Your participation helps researchers understand outcomes long after the initial treatment.
Camperdown, New South WalesAges 18 years+ - NCT05412810Recruiting
Test air-biomarker changes during ICU breathing machine use
This study looks for chemical “biomarkers” in samples taken during ICU care to better understand what happens during mechanical ventilation. It may help future care by identifying signs that could guide safer breathing-machine treatment.
Columbus, OhioAges 18–110 - NCT04180397RecruitingPhase 4
Removing extra fluid in critically ill ICU patients with overload
This trial studies a medicine strategy to remove extra fluid from the body in ICU patients who have fluid overload. It aims to see whether controlled fluid removal is safer and better for recovery than usual care.
SydneyAges 18 years+ - NCT04047784Enrolling by invitation
Using EBUS to help diagnose a blood clot in the lungs
This study looks at whether a procedure called EBUS (a camera passed through the airway) can help doctors diagnose an acute pulmonary embolism—a sudden blood clot in the lungs—in critically ill, intubated ICU patients. If you’re eligible, EBUS may be done during bronchoscopy as part of your usual care to help confirm or rule out the diagnosis.
Los Angeles, CaliforniaAges 18 years+ - NCT04534296Recruiting
Early mobilization for breathing muscles in critically ill children
This study looks at whether starting movement early in the first day of breathing support can help keep the diaphragm (a key breathing muscle) working better in critically ill children. The researchers will check diaphragm thickness using ultrasound and compare it to usual care.
ShanghaiAges 6 months–12 years - NCT02804438Recruiting
Pupil measurement checks in neurocritical care patients
This study collects normal (baseline) results from a handheld eye pupil camera (a pupillometer) used during routine neuro–intensive care checks. It may help clinicians better interpret these eye measurements in future patients.
Dallas, TexasAges Any age - NCT02539407Recruiting
Study drug levels in critically ill children
This trial measures how anti-infective medicines move through a child’s body while they are in the hospital or during follow-up. The goal is to better understand dosing and drug exposure in critically ill children.
ParisAges 1 day–18 years - NCT07110129Recruiting
Testing a new tool to see if you're ready to come off the breathing machine
This study tests a new way to check if your breathing muscles are strong enough to safely remove the breathing tube. It uses a special patch to measure how well your diaphragm works, which may help doctors make better decisions about when to take the tube out.
CardiffAges 18 years+ - NCT07109570Recruiting
Checking breathing effort in ICU patients on a ventilator
This trial measures how your breathing muscles work while we try taking you off the breathing machine. The results could help doctors predict when you're ready to breathe on your own.
LeidenAges 18 years+
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Common questions
- Are there clinical trials for critical illness?
- Yes. Clin2 currently lists 352 recruiting critical illness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critical illness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critical illness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.