Clinical trials
Cryptogenic Stroke clinical trials
Below are recruiting cryptogenic stroke clinical trials, each written for real people, not researchers. We’re tracking 17 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07224178Recruiting
Heart strain and stroke of unknown cause
This study looks at how well the left side of the heart pumps (called strain) in people who had a stroke without a known cause. It aims to see if this heart measurement can help predict future strokes or heart rhythm problems like atrial fibrillation.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06005233Recruiting
Smartwatch heart monitoring after unexplained stroke
This trial uses a smartwatch to look for hidden atrial fibrillation (an irregular heart rhythm) in people who have had a stroke or TIA with no known cause. It could help find the reason for the stroke and guide treatment to prevent another one.
MunichAges 40 years+ - NCT05565781Recruiting
Watch for hidden atrial fibrillation after unexplained stroke
This study uses a smartwatch and a longer heart-monitoring test (a Holter) to find an irregular heart rhythm called atrial fibrillation after a stroke whose cause is unclear. If they detect it, it may help guide better prevention and treatment to reduce future stroke risk.
Barcelona, CataloniaAges 55 years+ - NCT06542770Recruiting
Predicting hidden atrial fibrillation after cryptogenic stroke
This trial uses a small heart monitor to see if certain heart changes can predict hidden atrial fibrillation in people who had a stroke or mini-stroke with no clear cause. It aims to find those who might benefit from blood thinners to prevent another stroke.
BarcelonaAges 50–89 - NCT06880107Recruiting
Annexin A2 genetics and unexplained stroke
This study looks at certain genetic variations (specifically in a gene called Annexin A2) in people who have had a stroke with no known cause. It aims to understand if these genetic differences might be linked to this type of stroke.
AmiensAges 18 years+ - NCT04475510Recruiting
Stop blood-thinner therapy after PFO closure in younger stroke patients
This trial tests whether it’s safe to stop antithrombotic (blood-thinner) treatment after a successful hole-in-the-heart procedure (PFO closure) in people age 60 and under who had an unexplained stroke or TIA. It may help some people avoid long-term blood-thinner side effects if their risk stays low.
Québec, QuebecAges 18–60 - NCT06398366Enrolling by invitation
Heart tests to prevent another stroke
This study looks at how heart problems might cause strokes. If you had a stroke that doctors can't explain after many tests, this trial will do extra heart monitoring to find possible causes and help prevent another stroke.
Camden, New JerseyAges 18 years+ - NCT05907694Recruiting
Treatment of stroke from PFO, with or without closure
This study looks at whether treating a history of “cryptogenic” stroke (stroke with no clear cause) using a patent foramen ovale (PFO) closure, plus medical therapy, is better than medical therapy alone. It focuses on people over 60 with a heart shunt seen on an ultrasound of the heart.
Québec, QuebecAges 18 years+ - NCT07698951Recruiting
Testing a new device to close PFO after stroke
This trial tests a new device to close a PFO (a small hole in the heart) in people who have had a stroke caused by a blood clot passing through that hole. The goal is to see if the device can prevent another stroke.
BelgradeAges 18–65 - NCT07172464Recruiting
Study of a new device to close a hole in the heart after a stroke
This trial tests a new device to close a PFO (a small hole between the upper chambers of the heart) in people who have had a stroke caused by a blood clot. The goal is to prevent future strokes by blocking the hole.
Los Angeles, CaliforniaAges 18–65 - NCT05387954RecruitingPhase 3
PFO closure or blood thinners after stroke in ages 60–80
This trial studies the best way to prevent another stroke after a recent stroke in people ages 60 to 80 who have a “PFO” heart connection. It compares closing the PFO vs taking mouth blood-thinners or antiplatelet medicine, based on what your doctors determine is safest for you.
AmiensAges 60–80 - NCT07724171Recruiting
Long-term results after PFO closure surgery
This study looks at how well patients do over time after having a hole in their heart (patent foramen ovale, or PFO) closed with a small device inserted through a vein. It may help doctors understand the benefits and risks of the procedure.
SeoulAges 19 years+ - NCT04075084Recruiting
Watching outcomes of routine home monitoring after a heart monitor implant
This registry study follows people who get a BIOTRONIK implantable heart monitor and use home monitoring. It looks at how routine care and at-home check-ins work in real life, which may help improve support and tracking over time.
AdelaideAges 18 years+ - NCT05537753Recruiting
PFO closure device test after recent unexplained stroke
This trial tests whether closing a hole in the heart (a PFO) with a special device can help prevent another stroke after an unexplained stroke. You may be a candidate if your stroke likely happened because blood can pass through this PFO.
Little Rock, ArkansasAges 18–60 - NCT05733416Recruiting
FDG PET/CT scan after unexplained stroke to find hidden cancer
This study checks whether doing an intensive scan using FDG PET/CT shortly after a “cryptogenic” (unexplained) ischemic stroke can uncover an underlying cause, such as cancer. If a hidden source is found earlier, it may help guide the next treatment steps.
Ottawa, OntarioAges 18 years+ - NCT05774288Recruiting
Testing a device to close a heart opening called PFO
This trial studies whether a Cera™ device is safe and effective for closing a patent foramen ovale (PFO), a small hole in the heart. It is for adults whose PFO is linked to certain types of stroke or ongoing clot-related events.
Beijing, Beijing MunicipalityAges 18–60 - NCT07298122Recruiting
Heart imaging for hidden clots in ESUS stroke with left ventricular disease
This study uses advanced heart scans (MRI or CT) to look for blood clots in the heart of people who had a stroke with an unclear cause, specifically if they also have a mild heart condition affecting the left ventricle. The goal is to find hidden clots that might be causing strokes.
Milan, LombardyAges 18 years+
Hear when a new Cryptogenic Stroke trial opens
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Common questions
- Are there clinical trials for cryptogenic stroke?
- Yes. Clin2 currently lists 17 recruiting cryptogenic stroke studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cryptogenic stroke trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cryptogenic stroke trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.