Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06881693Recruiting
Online CBT for depression and anxiety in new parents
This study tests an internet-based cognitive behavioral therapy (CBT) program for parents who are expecting or have a new baby (up to 2 years old) and are struggling with depression or anxiety. It's designed to help you learn skills you can use at home, on your own schedule.
Regina, SaskatchewanAges 18 years+ - NCT06129890Recruiting
Brain stimulation for nerve pain and depression
This trial tests whether a noninvasive brain stimulation technique (rTMS) can help people with long-term nerve pain who also have depression. It aims to see if this treatment can reduce pain and improve mood.
Saint-EtienneAges 18–85 - NCT06876129RecruitingPhase 1
Adding D-serine to TMS for depression
This trial tests whether adding a medication called D-serine to a brain stimulation treatment (TMS) helps improve depression. It’s for adults with major depression who are already getting TMS therapy.
Belmont, MassachusettsAges 18–80 - NCT06871397Recruiting
Online support program for well-being in early pregnancy
This study tests an online program designed to help pregnant women feel better emotionally and mentally. It includes lessons and support you can access from your phone.
Reus, TarragonaAges 18 years+ - NCT06867549RecruitingPhase 2
Propofol for depression in older adults
This study tests if a medicine called propofol (given through an IV) can help improve depression symptoms by boosting slow brain waves during sleep. It is for people 60 and older whose depression has not fully responded to standard antidepressants.
St Louis, MissouriAges 60 years+ - NCT06860958RecruitingPhase 3
Adding roflumilast to antidepressants for depression
This study tests if adding roflumilast, a medicine that reduces inflammation, can help people with major depression feel better when taken with their current antidepressant. It is for adults with moderate to severe depression.
TantaAges 18–65 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06856161Recruiting
Blood test to help diagnose mental health conditions
This study is testing a new blood test that might help doctors better understand and diagnose conditions like depression, psychosis, or schizophrenia. If you are 19 or older and have one of these conditions, you may be able to join.
New Westminster, British ColumbiaAges 19 years+ - NCT06853587Recruiting
Genetic test to help pick antidepressant for teens
This study tests whether using a cheek swab DNA test can help choose a better antidepressant for teenagers with anxiety or depression. The goal is to see if this personalized approach leads to fewer side effects and better results.
Calgary, AlbertaAges 12–17 - NCT05962216Recruiting
Real-world check of Rexulti for schizophrenia and depression
This study looks at how well brexpiprazole (Rexulti) works in everyday treatment, and how people feel and function over time. You may be eligible if you’re newly started on Rexulti and have a qualifying mental health diagnosis.
Hong KongAges 18–65 - NCT06358898Recruiting
Digital sleep and mood program for teens with depression
This trial tests a digital program that uses a smartphone app to help teens with both insomnia and depression. It combines a mood tracker with cognitive behavioral therapy for insomnia (CBT-I) to improve sleep and mood.
Shatin, New TerritoriesAges 12–18 - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Phoenix, ArizonaAges 18–65 - NCT06833567Recruiting
Mentalizing therapy for anxiety and depression
This study tests a group therapy that helps people understand their own and others' thoughts and feelings. It may help if you have anxiety or depression and can talk in a group setting.
Málaga, MalagaAges 18 years+ - NCT06831435Recruiting
Digital therapy for depression study
This study tests if a digital cognitive behavioral therapy program can help treat depression in real-world settings. It is designed for people aged 14 to 60 who have moderate to severe depression symptoms.
Beijing, Beijing MunicipalityAges 14–60 - NCT06831968Recruiting
Blood test to predict postpartum depression risk
This study tests a new blood test to predict who might get postpartum depression (sadness or mood changes after giving birth). If you are early in your pregnancy (less than 30 weeks), you may be able to join and help find out if the test works.
Charlottesville, VirginiaAges 18 years+ - NCT06833788RecruitingPhase 4
Intravenous vs oral iron for anaemia after caesarean: effect on postpartum depression
This study compares two ways of treating low red blood cells (anaemia) after a caesarean delivery: iron given through a vein (IV) versus iron taken by mouth (oral pills). The goal is to see if either method helps prevent or reduce symptoms of postpartum depression, which can be linked to anaemia.
ParisAges 18 years+ - NCT06824415Recruiting
Sleep TMS for depression
This trial tests whether a type of brain stimulation called TMS (transcranial magnetic stimulation), given during sleep, can improve depression. It's for adults who have not gotten enough relief from antidepressant medication.
Stanford, CaliforniaAges 18–65 - NCT06821646Enrolling by invitation
Brain responses in depression and autism with TMS and EEG
This study uses brain stimulation (TMS) and brain wave recording (EEG) to understand how the brain works in people with autism, depression, or both. It may help find better ways to treat these conditions.
TaipeiAges 20–50 - NCT06816329Recruiting
Stress and depression risk study for teenage girls
This study looks at how stress affects teenage girls who may be at higher risk for depression due to a parent's history. It involves MRI scans and daily surveys on a cell phone.
Belmont, MassachusettsAges 13–15 - NCT06818734Recruiting
Testing a tool for postpartum depression screening
This trial tests a tool that helps doctors screen for postpartum depression during pregnancy. You may be eligible if you are at least 20 weeks pregnant and receive care at a participating clinic.
Brooklyn, New YorkAges 18 years+ - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06805851Recruiting
Depression, antidepressants, and body temperature in exercise
This study looks at how depression and certain antidepressants affect how your body controls temperature during exercise. You'll do some exercise tests while researchers check your body temperature and heart rate.
University Park, PennsylvaniaAges 18–40 - NCT06801041RecruitingPhase 2
Psilocybin therapy for anxiety or depression in cancer survivors
This trial tests if a single dose of psilocybin, given with therapy, can help cancer survivors who struggle with anxiety or depression. You would travel to MD Anderson for treatment and follow-up, and must stop certain medications beforehand.
Houston, TexasAges 18 years+ - NCT06795451RecruitingPhase 1/Phase 2
Spinal stimulation for depression: a clinical trial
This study tests if a non-invasive spinal stimulation device can improve depression symptoms. It is for people currently taking an antidepressant for at least 8 weeks but still experiencing depression.
Mason, OhioAges 18–60
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.