Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Little Rock, ArkansasAges 18 years+ - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT06784388RecruitingEarly Phase 1
Deep brain stimulation for tough-to-treat depression
This early trial tests a personalized deep brain stimulation (DBS) approach for people with major depression that hasn't improved with at least two different antidepressants. DBS uses small electrodes placed in the brain to adjust mood-related circuits.
Hangzhou, ZhejiangAges 18–70 - NCT06790641Recruiting
Supporting mental health during and after pregnancy
This study aims to improve mental health care for people during and after pregnancy. It involves interviews or focus groups with healthcare providers, peer mentors, and patients to understand how to make support services more helpful and accessible.
Shrewsbury, MassachusettsAges 18–70 - NCT05661383Recruiting
Smell and brain stimulation for hard-to-treat depression
This trial studies whether stimulating the brain and senses related to smell can reduce symptoms in people with depression that has not responded to usual treatment. It may help by testing new non-drug approaches for improving mood and motivation.
BronAges 18 years+ - NCT06775548Enrolling by invitation
Exercise and vitamins for depression relief
This study tests if combining aerobic and resistance exercises with vitamins D and E can reduce stress and inflammation in people with mild to moderate depression. It may help improve mood and overall well-being.
Karachi, SindhAges 25–35 - NCT06781697RecruitingPhase 3
Ketamine and virtual reality for treatment-resistant depression
This trial tests if adding virtual reality to ketamine treatments can help people with depression that hasn't improved with other treatments. You'll receive IV ketamine as prescribed by your doctor and also use a virtual reality headset during sessions.
Toronto, OntarioAges 18 years+ - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT06772701Recruiting
French depression screening test for new fathers
This study checks if a questionnaire used to spot postpartum depression in mothers also works well for fathers after their baby is born. It is only for French-speaking dads with a newborn up to 10 days old.
ClamartAges 18 years+ - NCT06658041Recruiting
A step-by-step program for mild to moderate depression
This trial tests a structured support program for adults with mild to moderate depression. It uses a team-based approach in primary care to help you feel better step by step.
Hong Kong, HONG KONGAges 45–59 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06770244Enrolling by invitation
Positive psychology for postpartum depression in primary care
This trial tests a program based on positive psychology to help prevent or reduce postpartum depression. It is offered within the primary healthcare system and focuses on supporting mothers early in pregnancy.
Wuhan, HubeiAges 18 years+ - NCT06763081Recruiting
SSRI side effects genetics study
This study looks at why some people have behavioral side effects when taking SSRI antidepressants like Prozac or Zoloft. It hopes to find a genetic reason to help doctors choose safer treatments in the future.
Winnipeg, ManitobaAges 6–24 - NCT06759558RecruitingPhase 2
Zuranolone for post-stroke depression
This trial tests a new medicine called zuranolone (allopregnanolone) for people with depression after a stroke. It aims to see if the drug can help improve mood when taken over a short period.
Durham, North CarolinaAges 21–65 - NCT06751784RecruitingPhase 2
Fampridine's effect on memory in mild to moderate depression
This study tests whether the drug fampridine can improve working memory (like short-term memory and focus) in people with mild to moderate depression. The trial is run by the University of Basel and involves multiple visits.
Basel, Canton of Basel-CityAges 18–55 - NCT06740331Recruiting
Thinking and memory study for mood disorders
This study looks at how people with bipolar disorder or depression process social situations, memory, and thinking. It compares patients, their relatives, and healthy volunteers to better understand these conditions.
ReimsAges 18–65 - NCT06746155Recruiting
Predictors of relapse in major depression
This study looks at adults with major depressive disorder who have responded to treatment, to find out what might predict a relapse. You will wear a wrist activity monitor and complete questionnaires.
Calgary, AlbertaAges 18–70 - NCT06748209RecruitingPhase 4
Mobile TMS for treatment-resistant depression
This trial tests if delivering transcranial magnetic stimulation (TMS) through a mobile unit can help people with depression that hasn't improved with other treatments.
Charleston, South CarolinaAges 22–80 - NCT06732284Recruiting
Sleep inertia study in depression
This study looks at sleep inertia (the grogginess you feel after waking up) in people with major depression. It uses a simple reaction-time test to understand how depression affects waking up.
NîmesAges 18–54 - NCT06721559Recruiting
Home program for older adults with depression and mobility issues
This study tests a home-based program called Empower@Home for older adults who have depression and trouble moving around. It aims to see if the program helps improve mood and daily life—without adding extra outside therapy.
Ann Arbor, MichiganAges 50 years+ - NCT06707012RecruitingPhase 4
Metformin plus antidepressants for depression in obesity
This trial tests whether adding metformin (a diabetes medicine) to usual antidepressant treatment can help improve depression in people who are overweight or obese. It is for adults age 18–44 who are newly diagnosed with depression and do not have diabetes.
Karachi, SindhAges 18–45 - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT06709027Enrolling by invitation
Mobile health program for depression in older adults
This study is testing a smartphone-based health program designed for older adults with depression. The program aims to help you manage your mood and track changes in thinking and memory using a mobile app.
Fuzhou, FujianAges 60 years+ - NCT06698666RecruitingPhase 3
Can statins help treat depression?
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
Cairo, Al AbbasiaAges 20–45
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.