Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06582784Recruiting
Using a phone app to help cancer survivors with depression
This study tests a mobile app to help cancer survivors who are feeling depressed. If you have a smartphone and are willing to use an app for mood support, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT06589544Recruiting
Virtual reality and brain stimulation for depression in cancer patients
This trial tests whether combining virtual reality therapy with transcranial magnetic stimulation (a non-invasive brain treatment) can help reduce depression in people who have had cancer in the last 5 years. It aims to improve mood without using medication.
Ferrara, FEAges 18–100 - NCT06592573Recruiting
Anxiety and depression support for cancer caregivers
This trial tests whether online or in-person support can help reduce anxiety and depression symptoms in people caring for a loved one with cancer. You may be eligible if you're feeling anxious or down and are not currently in therapy.
Bologna, BOAges 18 years+ - NCT06592833RecruitingPhase 2
Psilocybin with or without pimavanserin for depression
This study tests whether combining psilocybin (a psychedelic substance) with pimavanserin (a medication that may help reduce side effects) works better than psilocybin alone for treating major depressive disorder. It may help people who have not responded well to other treatments.
New York, New YorkAges 21–80 - NCT06599099Recruiting
Deep brain stimulation for depression that hasn't responded to other treatments
This trial tests if deep brain stimulation (a surgical implant that sends gentle electrical pulses to a specific area of the brain) can help people with bipolar I disorder who are currently in a severe depressive episode and have not found relief from multiple treatments.
Boston, MassachusettsAges 22–64 - NCT06601140Recruiting
Testing a smartphone app for tracking depression symptoms
This study tests a smartphone-based emotional monitoring device (EMOCARE) to see if it can accurately measure your mood compared to a standard depression questionnaire. It may help researchers find a simpler way to track depression symptoms.
AgenAges 18 years+ - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45 - NCT06610552Recruiting
Powerly: Preventing depression and anxiety after childbirth
This trial tests a science-based smartphone program to help prevent postpartum depression and anxiety. It is designed for pregnant women who are between 24 and 32 weeks along and have an iPhone.
ZurichAges 18 years+ - NCT06626152RecruitingPhase 2
L-DOPA challenge test for depression in older adults
This study tests whether a medication called L-DOPA (used for Parkinson's disease) can help predict how well older adults with depression will respond to treatment. You will take a single dose of L-DOPA and then do simple tasks to measure your mood and thinking.
Vancouver, British ColumbiaAges 60 years+ - NCT06628986Recruiting
Mindfulness and NLP for postpartum mood and breastfeeding
This study tests whether combining mindfulness (MBSR) and a gentle brain-training method (NLP) can help new mothers feel better after childbirth and improve their breastfeeding experience. It may be a good fit if you are a first-time mom who had a C-section and is breastfeeding.
Sanliurfa, Eyalet/YerleşkeAges 19–35 - NCT06630065Recruiting
Ketamine study for depression using brain scans
This trial uses brain scans to understand how ketamine affects negative emotions in people with depression. It may help explain why ketamine works and who benefits most.
Paris, ParisAges 18 years+ - NCT06632782Recruiting
Breathing exercise for anxiety and depression in type 2 diabetes
This study tests whether a simple breathing exercise (pyramid breath awareness) can help reduce anxiety and depression symptoms in people with type 2 diabetes. It is a short, non-drug program that may offer a natural way to feel better emotionally.
Kuwait City, KuwaitAges 30–80 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Birmingham, AlabamaAges 18–65 - NCT06651801Recruiting
Group therapy for anxiety or depression
This trial tests whether a virtual group therapy program is a good way to help people in Manitoba with anxiety or depression. If you're looking for support and can join a small online group, this might be a helpful option.
Winnipeg, ManitobaAges 18 years+ - NCT06658795Recruiting
Can brain stimulation help older adults with depression and loneliness?
This study tests whether a gentle brain stimulation technique called tDCS (transcranial direct current stimulation) can reduce loneliness in older adults with depression. It involves wearing a headband during sessions and comparing results to a placebo group.
Guangzhou, GuangdongAges 60–80 - NCT06675851RecruitingPhase 4
Dopamine changes in the brains of depressed and healthy people
This study uses brain scans to look at dopamine — a chemical messenger related to reward and mood — in people with depression and healthy volunteers. Researchers want to understand how dopamine changes in depression, which may lead to better treatments.
ViennaAges 18–65 - NCT06695767Recruiting
Behavioral therapy for epilepsy and depression in veterans
This trial tests a special therapy program for veterans who have both epilepsy and major depression. It uses talk therapy and text message support to help improve mood and seizure control.
Houston, TexasAges 18 years+ - NCT06698107Recruiting
Childbirth education for teen mothers to prevent depression
This program tests a special childbirth education class designed to help first-time teen mothers feel more confident and prepared, with the goal of reducing the chance of depression after the baby is born.
Bahir Dar, AmharaAges 13–19 - NCT06698666RecruitingPhase 3
Can statins help treat depression?
This trial tests if adding a statin (a cholesterol-lowering medicine) to your current depression treatment improves symptoms. It is for adults aged 20 to 45 with mild to moderate depression who are not already taking a statin.
Cairo, Al AbbasiaAges 20–45 - NCT06702722Recruiting
Therapy and HIV support for moms in Malawi
This study tests if combining problem-solving therapy with HIV care support can improve mental health and HIV outcomes for pregnant women living with HIV in Malawi who have elevated depressive symptoms.
LilongweAges 18 years+ - NCT06707012RecruitingPhase 4
Metformin plus antidepressants for depression in obesity
This trial tests whether adding metformin (a diabetes medicine) to usual antidepressant treatment can help improve depression in people who are overweight or obese. It is for adults age 18–44 who are newly diagnosed with depression and do not have diabetes.
Karachi, SindhAges 18–45 - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Dothan, AlabamaAges 10–17 - NCT06445933Recruiting
Vitamin B6 for depression in pregnancy and after birth
This trial tests whether taking Vitamin B6 can help prevent depression in pregnant women and new mothers. If you are between 24 and 28 weeks pregnant and have no history of mental health conditions, you may be able to join.
TaipeiAges 20–50 - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+
Hear when a new Depressed trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,507 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.