Clinical trials
Depression Disorders clinical trials
Below are recruiting depression disorders clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07404085Recruiting
Boosting thinking skills with training and medication in mood or schizophrenia disorders
This study tests whether adding a medication that may improve brain flexibility makes memory and thinking training work better for people with bipolar disorder, recurring depression, or schizophrenia spectrum disorders. It could help improve daily thinking skills and quality of life.
Frederiksberg, Capital Region of DenmarkAges 35–75 - NCT07282678Recruiting
Adaptive brain stimulation for treatment-resistant depression.
This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.
Durham, North CarolinaAges 22 years+ - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Birmingham, AlabamaAges 18–65 - NCT07263321Recruiting
Depression treatment choice in general practice
This study helps people with moderate depression decide between medication and therapy. Your doctor will work with you to pick the best option.
AalborgAges 18–65 - NCT06724666Recruiting
Online therapy for teens with anxiety or depression
This study tests an online therapy program for teens aged 13–17 who feel anxious, depressed, or both. The program is designed to help you understand and manage these feelings through short, internet-based sessions, and you can do it from home.
Cluj-NapocaAges 13–17 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT06621394Recruiting
Mediterranean diet and mindful eating for depression and obesity
This study tests if a Mediterranean diet combined with mindful eating can help reduce depression severity in people who have both obesity and major depressive disorder. You would follow a special eating plan and learn mindfulness techniques to see if they improve your mood.
StuttgartAges 18 years+ - NCT06879977Recruiting
Body Awareness Study for People with Depression
This trial studies how people with depression experience body awareness while in the hospital. It may help us understand the connection between body and mind in treating depression.
LinzAges 18–69 - NCT07212075Recruiting
Digital twin study for mental health in diabetes
This study uses digital twins—a virtual model of your health—to track how your mental health changes with diabetes. It aims to find patterns that could help personalize mental health care.
Bad Mergentheim, Baden-WurttembergAges 18–80 - NCT07191392Recruiting
Brain stimulation for depression using focused electric fields
This trial tests whether temporal interference stimulation (a noninvasive brain stimulation method) can improve symptoms of depression. It focuses on people who are currently experiencing moderate to severe depression.
Hefei, AnhuiAges 12–60 - NCT07161700Enrolling by invitationPhase 2
Long-term safety study of SPT-300 for major depression
This study is for people who finished the earlier BUOY-1 study of SPT-300 and want to continue treatment. It tests the long-term safety and tolerability of SPT-300 for major depressive disorder, with or without anxious distress.
Chino, CaliforniaAges 18–66 - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT07111390Recruiting
Home-based light therapy for major depression
This trial tests whether a special light you can use at home can help treat major depression. It's a 60Hz light that you turn on and off repeatedly. If you're 24–65, have depression, and take a stable antidepressant, you may be able to participate.
New York, New YorkAges 24–65 - NCT02752542RecruitingPhase 4
Personalized therapy and antidepressants for depression
This trial studies whether a personalized combination of talk therapy (CBT) and antidepressant medication works better for people with moderate to severe depression. It’s meant to match treatment choices to your situation and to see what helps most.
Halifax, Nova ScotiaAges 18 years+ - NCT07088939Recruiting
Online skills course for depression and anxiety
This trial tests an online course that teaches skills to manage emotions. It is for people in Ontario with mild depression or anxiety who are not currently in therapy.
Windsor, OntarioAges 18 years+ - NCT07082998Recruiting
Heated yoga vs. sauna for depression
This study compares heated yoga with sauna sessions to see which helps reduce depression. You'll also use a mindfulness app. Both treatments are meant to boost mood and well-being.
Boston, MassachusettsAges 18–65 - NCT07065240RecruitingPhase 2
Study of SPT-300 for major depression with or without anxiety
This trial tests an experimental oral medication, SPT-300, for people with major depressive disorder, even if they also have mild anxiety. The goal is to see if it helps improve mood safely.
Chino, CaliforniaAges 18–65 - NCT07060690Recruiting
Online support program for depressed women
This trial tests a personalized online program with human support to see if it can help women with depression and possibly improve mental health and biological markers. It might be an option if you are a woman with moderate depression and you are comfortable using digital devices.
Barcelona, BarcelonaAges 18–45 - NCT07028216Recruiting
Mindful Self-Compassion for Anxiety and Depression
This study tests whether a program called Mindful Self-Compassion (MSC) can help people with anxiety or depression who tend to be hard on themselves. You will be assigned to learn MSC either in a group class or online.
Washington D.C., District of ColumbiaAges 18–65 - NCT07033923Recruiting
Brain study of mood changes in depression and bipolar disorder
This study uses a mobile app and brain scans to understand day-to-day mood changes in people with depression or bipolar disorder. It may help doctors learn how to better predict and treat these conditions.
Paris, ParisAges 18 years+ - NCT06967857RecruitingPhase 2
Dexamfetamine for adults with ADHD and depression
This trial tests a study medication (dexamfetamine) for adults who have both ADHD and moderate to severe depression. It aims to see if the medication is safe and helps improve both conditions.
BerlinAges 18–65 - NCT06913309Recruiting
Home bright light therapy for teen depression
This study tests whether a bright light therapy device you can use at home can help improve depression symptoms in teenagers aged 13-17. It compares the results of using the light with a non-active placebo device.
Beijing, Beijing MunicipalityAges 13–17 - NCT06909669Recruiting
Brief therapy for anxiety, depression, or physical symptoms
This study tests short-term psychological treatments to help people with mild or moderate emotional symptoms like anxiety, depression, or physical complaints (such as pain or fatigue) that may be linked to stress. The goal is to see if these brief therapies can improve how you feel.
Córdoba, CórdobaAges 18 years+ - NCT06878859Recruiting
Online program for depression and cannabis use
This study tests a digital (online) program designed to help people who struggle with both depression and cannabis use. If you're feeling down and also using cannabis more than you'd like, this program might help you manage both.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for depression disorders?
- Yes. Clin2 currently lists 669 recruiting depression disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.