Clinical trials · Detroit, MI
Depression clinical trials in Detroit
We’re tracking 26 recruiting depression studies with a site in or near Detroit — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Detroit
- NCT07222306Enrolling by invitation
Cannabis, brain inflammation, and suicidal thoughts brain imaging study
This study uses brain scans to see how cannabis affects inflammation and suicidal thoughts. You may join if you're already in a related study and can safely undergo MRI and PET scans.
Detroit, MichiganAges 19–69 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Detroit, MichiganAges 18–50 - NCT05965310Recruiting
Virtual psychology support for ACL repair recovery
This study tests a virtual (online) psychological program to help people recover after ACL ligament surgery. It focuses on first-time ACL repairs and aims to improve how patients cope during recovery.
Detroit, MichiganAges 13 years+ - NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07227389Recruiting
Opioid Timing and Breathing Risk After Surgery
This study looks at when opioids are given during surgery and how it affects breathing problems after surgery. It might help understand how to make pain control safer.
Detroit, MichiganAges 18–85 - NCT07088939Recruiting
Online skills course for depression and anxiety
This trial tests an online course that teaches skills to manage emotions. It is for people in Ontario with mild depression or anxiety who are not currently in therapy.
Windsor, OntarioAges 18 years+ - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Troy, MichiganAges 18–75 - NCT07775300RecruitingPhase 3
Study of an injectable drug for major depressive disorder
This study tests an investigational drug called brenipatide for major depressive disorder. It is given as a self-injection and is being compared to a placebo to see if it helps improve depression symptoms in people who are already on standard treatment.
Troy, MichiganAges 18–75 - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Bloomfield Hills, MichiganAges 18–75 - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Bloomfield Hills, MichiganAges 10–17 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Rochester Hills, MichiganAges 18–64 - NCT06430333RecruitingPhase 2
Sleep therapy to prevent depression in pregnancy
This study tests whether a sleep-focused therapy can help prevent depression in pregnant people who have insomnia. If you are 14–31 weeks pregnant and have trouble sleeping, this trial offers a program to improve your sleep and lower your risk of depression.
Novi, MichiganAges 18 years+ - NCT06721559Recruiting
Home program for older adults with depression and mobility issues
This study tests a home-based program called Empower@Home for older adults who have depression and trouble moving around. It aims to see if the program helps improve mood and daily life—without adding extra outside therapy.
Ann Arbor, MichiganAges 50 years+ - NCT01809080Enrolling by invitation
Intern and medical student health check study
This study looks at the health of new interns and some final-year medical students in several training programs. It may help improve care and support for people early in their medical careers.
Ann Arbor, MichiganAges Any age - NCT06856057Recruiting
Support for caregivers and kids after injury
This study helps parents and young children cope with stress after a hospital stay for an injury. It tests a program to improve mental health for both caregivers and kids.
Ann Arbor, MichiganAges 18 years+ - NCT07052357Enrolling by invitation
Intern health study 2025
This study looks at how medical interns' health changes during their first year of training. You wear a wrist device and answer questions on your phone to help researchers understand stress, sleep, and well-being.
Ann Arbor, MichiganAges 18 years+ - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT07392879Recruiting
Virtual nature walks for depression in MS
This study tests whether virtual reality nature walks can help improve depression in people with progressive multiple sclerosis. You will use a VR headset at home to watch calming nature scenes, and researchers will see how it affects your mood.
Ann Arbor, MichiganAges 18 years+ - NCT06584422Recruiting
Online program for depression in older adults
This study tests an online program called Empower@Home that helps older adults with symptoms of depression. It compares the program to usual care to see if it improves mood and well-being.
Ann Arbor, MichiganAges 50 years+ - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Ann Arbor, MichiganAges 18 years+ - NCT06839859RecruitingPhase 2
Family Acceptance Project online pilot study
This trial tests an online program called Family Acceptance Project to help LGBTQ+ youth of color and their families improve acceptance and reduce rejection. You and a caregiver will join separate online group sessions to learn communication and support skills.
Ann Arbor, MichiganAges 14 years+ - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Ann Arbor, MichiganAges 18 years+ - NCT06656416RecruitingPhase 2
Study of ALTO-100 for bipolar depression
This study tests an investigational drug called ALTO-100 for people with bipolar disorder who are currently experiencing depression. It aims to see if ALTO-100 can help improve depressive symptoms when added to your current mood stabilizer or antipsychotic medication.
Ann Arbor, MichiganAges 18–70
Hear when a new Depression trial opens near Detroit, MI
We’ll email you when one opens near Detroit, MI — at most once a week, no account needed, unsubscribe anytime.
Depression trials in other cities
Where these studies are running near Detroit
Institutions with a site for the recruiting depression studies listed above.
- University of Michigan · 7 studies
- Arcturus Healthcare, PLC · 2 studies
- Henry Ford Health · 2 studies
- C S Mott Children's Hospital
- Detroit Medical Center
- Detroit Recovery Project
- Henry Ford Macomb Hospital-Clinton Township
- Henry Ford Medical Center
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Michigan.
Common questions
- Are there depression clinical trials near Detroit?
- Yes. We're currently tracking 26 recruiting depression studies with a site near Detroit, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Detroit?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Detroit to take part?
- Not necessarily. These studies have a site near Detroit, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Detroit regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.