Clinical trials · Michigan
Depression clinical trials in Michigan
We’re tracking 29 recruiting depression studies with a site in Michigan — including Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Michigan
- NCT07766161Recruiting
Light therapy for postpartum depression
This trial tests whether timed light therapy can improve postpartum depression symptoms. It focuses on new mothers within six months of giving birth who have elevated depression scores.
Ann Arbor, MichiganAges 18 years+ - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Ann Arbor, MichiganAges 18 years+ - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Troy, MichiganAges 18–75 - NCT07227389Recruiting
Opioid Timing and Breathing Risk After Surgery
This study looks at when opioids are given during surgery and how it affects breathing problems after surgery. It might help understand how to make pain control safer.
Detroit, MichiganAges 18–85 - NCT06721559Recruiting
Home program for older adults with depression and mobility issues
This study tests a home-based program called Empower@Home for older adults who have depression and trouble moving around. It aims to see if the program helps improve mood and daily life—without adding extra outside therapy.
Ann Arbor, MichiganAges 50 years+ - NCT06584422Recruiting
Online program for depression in older adults
This study tests an online program called Empower@Home that helps older adults with symptoms of depression. It compares the program to usual care to see if it improves mood and well-being.
Ann Arbor, MichiganAges 50 years+ - NCT07052357Enrolling by invitation
Intern health study 2025
This study looks at how medical interns' health changes during their first year of training. You wear a wrist device and answer questions on your phone to help researchers understand stress, sleep, and well-being.
Ann Arbor, MichiganAges 18 years+ - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT06430333RecruitingPhase 2
Sleep therapy to prevent depression in pregnancy
This study tests whether a sleep-focused therapy can help prevent depression in pregnant people who have insomnia. If you are 14–31 weeks pregnant and have trouble sleeping, this trial offers a program to improve your sleep and lower your risk of depression.
Novi, MichiganAges 18 years+ - NCT06574035Recruiting
Exercise and counseling for Black men with diabetes
This study tests whether a program combining physical activity with cognitive behavioral therapy (a type of talk therapy) helps African American men manage type 2 diabetes better. You would attend weekly exercise and counseling sessions for several months.
Ann Arbor, MichiganAges 18 years+ - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Bloomfield Hills, MichiganAges 10–17 - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Rochester Hills, MichiganAges 18–64 - NCT07392879Recruiting
Virtual nature walks for depression in MS
This study tests whether virtual reality nature walks can help improve depression in people with progressive multiple sclerosis. You will use a VR headset at home to watch calming nature scenes, and researchers will see how it affects your mood.
Ann Arbor, MichiganAges 18 years+ - NCT07553637RecruitingPhase 2
ALTO-207 for Adults With Hard-to-Treat Depression
This study tests whether a new medication called ALTO-207 can help people with depression that hasn't improved with standard antidepressants. You may qualify if you've tried multiple antidepressants without enough relief and are willing to add this experimental treatment to your current medication.
Ann Arbor, MichiganAges 18–75 - NCT06529029RecruitingPhase 2/Phase 3
Comparing new low-pulse ECT to standard ECT for depression
This trial tests a new type of seizure therapy (low amplitude pulse seizure therapy) against the standard ultra-brief right unilateral ECT for people with severe depression, including those with suicidal thoughts. The goal is to see which treatment works better.
Grand Rapids, MichiganAges 18–90 - NCT07222306Enrolling by invitation
Cannabis, brain inflammation, and suicidal thoughts brain imaging study
This study uses brain scans to see how cannabis affects inflammation and suicidal thoughts. You may join if you're already in a related study and can safely undergo MRI and PET scans.
Detroit, MichiganAges 19–69 - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Ann Arbor, MichiganAges 18 years+ - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Ann Arbor, MichiganAges Any age - NCT01809080Enrolling by invitation
Intern and medical student health check study
This study looks at the health of new interns and some final-year medical students in several training programs. It may help improve care and support for people early in their medical careers.
Ann Arbor, MichiganAges Any age - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Alma, MichiganAges 18–50 - NCT05700760Recruiting
ROSE program study to prevent postpartum depression
This study tests whether a program called ROSE can help prevent postpartum depression after delivery. If you’re pregnant, you may be asked to complete questionnaires and be reached by phone for study steps.
Flint, MichiganAges 18 years+ - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Pokagon, MichiganAges 14 years+
Depression trials by city in Michigan
Where these studies are running in Michigan
Institutions with a site for the recruiting depression studies listed above.
- University of Michigan · 11 studies
- Henry Ford Health System · 2 studies
- Allegiance Health
- Arcturus Healthcare, PLC
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
- Corewell Health Reed City Hospital
- Detroit Medical Center
- Henry Ford Cancer Institute-Downriver
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Michigan?
- Yes. We're currently tracking 29 recruiting depression studies with a site in Michigan, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Michigan?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Michigan to take part?
- Not necessarily. These studies have a site in Michigan, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Michigan regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.