Clinical trials · Raleigh–Durham, NC
Depression clinical trials in Raleigh–Durham
We’re tracking 20 recruiting depression studies with a site in or near Raleigh–Durham — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies near Raleigh–Durham
- NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Cary, North CarolinaAges 18–65 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Cary, North CarolinaAges 18 years+ - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Cary, North CarolinaAges 18–74 - NCT06656416RecruitingPhase 2
Study of ALTO-100 for bipolar depression
This study tests an investigational drug called ALTO-100 for people with bipolar disorder who are currently experiencing depression. It aims to see if ALTO-100 can help improve depressive symptoms when added to your current mood stabilizer or antipsychotic medication.
Cary, North CarolinaAges 18–70 - NCT07115329RecruitingPhase 2
Testing Zelquistinel for major depression
This study tests a new oral medication called Zelquistinel (taken as a tablet) against a placebo for treating major depressive disorder. Researchers want to see if it can reduce depression symptoms, especially when other antidepressants haven't been tried or haven't worked.
Raleigh, North CarolinaAges 18–64 - NCT07282678Recruiting
Adaptive brain stimulation for treatment-resistant depression.
This study tests a new brain stimulation device that adjusts its signal in real time to treat depression. It's for people who haven't gotten enough help from antidepressants and are looking for a non-drug option.
Durham, North CarolinaAges 22 years+ - NCT07050355Recruiting
Brain stimulation and exercise for depression after stroke
This study tests whether combining brain stimulation with aerobic exercise can help treat depression and improve walking in people who have had a stroke at least a year ago. If you have ongoing depressive symptoms and some leg weakness from your stroke, this treatment may help you feel better and walk more easily.
Durham, North CarolinaAges 21 years+ - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06759558RecruitingPhase 2
Zuranolone for post-stroke depression
This trial tests a new medicine called zuranolone (allopregnanolone) for people with depression after a stroke. It aims to see if the drug can help improve mood when taken over a short period.
Durham, North CarolinaAges 21–65 - NCT06188923RecruitingPhase 2
Pregnenolone for anxiety and depression in veterans
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Durham, North CarolinaAges 18–65 - NCT06627764Recruiting
Family support program for Latino families with teens
This study tests a family-based program to help Latino families with teenagers aged 12-17. The program addresses overlapping health and social challenges to improve family well-being.
Durham, North CarolinaAges 12–100 - NCT05282277RecruitingPhase 4
Estradiol to improve brain and reward changes in midlife women
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Chapel Hill, North CarolinaAges 45–55 - NCT06696001Recruiting
Brain Study of Talk Therapy for Depression
This study looks at how your brain works during talk therapy for depression. It aims to find out how therapy helps you feel better so that future treatments can be more personalized.
Chapel Hill, North CarolinaAges 18–30 - NCT06072677Recruiting
Mood and testosterone in young teens
This study looks at how mood changes during puberty in young people aged 11 to 14. It tests whether using a mindfulness app (Healthy Minds) can help teens who have been through stress or feel down.
Chapel Hill, North CarolinaAges 11–14 - NCT07822321RecruitingPhase 3
Brexanolone for severe postpartum depression
This trial tests an investigational medicine to help mothers with severe depression that started late in pregnancy or shortly after childbirth. It aims to improve mood and overall well-being.
Chapel Hill, North CarolinaAges 15–45 - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45 - NCT07048574Recruiting
Mood and behavior in children with cystic fibrosis
This study looks at mood and behavior in children with cystic fibrosis (CF) under 12. By following children over time, researchers hope to better understand and help with depression, anxiety, and behavior challenges that may come up.
Chapel Hill, North CarolinaAges 1.5 years–11 years - NCT07507370Recruiting
CARED: A fast new treatment plan for depression
This study tests a quick treatment approach for adults with major depression who have not gotten enough help from at least one antidepressant. It aims to see if a new rapid method can improve mood safely.
Chapel Hill, North CarolinaAges 18–70 - NCT06587230Recruiting
Tealeaf-NC: Teacher-led support for students in North Carolina
This study tests the Tealeaf program, where teachers and school staff work together to support students who may be struggling emotionally or behaviorally. It aims to help students in kindergarten through 8th grade who have elevated scores on a behavior and emotions questionnaire.
Chapel Hill, North CarolinaAges 5–99 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Burlington, North CarolinaAges 18–50
Hear when a new Depression trial opens near Raleigh–Durham, NC
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Depression trials in other cities
Where these studies are running near Raleigh–Durham
Institutions with a site for the recruiting depression studies listed above.
- Carolina Center for Neurostimulation · 2 studies
- Magnolia Clinical Research · 2 studies
- University of North Carolina at Chapel Hill · 2 studies
- Carolina Crossing B, Suite 1
- Cone Health Cancer Center at Alamance Regional
- Duke South Neurology Clinic 1L
- Duke University Medical Center
- Duke University School of Medicine
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in North Carolina.
Common questions
- Are there depression clinical trials near Raleigh–Durham?
- Yes. We're currently tracking 20 recruiting depression studies with a site near Raleigh–Durham, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Raleigh–Durham?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Raleigh–Durham to take part?
- Not necessarily. These studies have a site near Raleigh–Durham, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Raleigh–Durham regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.