Clinical trials · South Carolina
Depression clinical trials in South Carolina
We’re tracking 28 recruiting depression studies with a site in South Carolina — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in South Carolina
- NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
North Charleston, South CarolinaAges 18 years+ - NCT07050355Recruiting
Brain stimulation and exercise for depression after stroke
This study tests whether combining brain stimulation with aerobic exercise can help treat depression and improve walking in people who have had a stroke at least a year ago. If you have ongoing depressive symptoms and some leg weakness from your stroke, this treatment may help you feel better and walk more easily.
Charleston, South CarolinaAges 21 years+ - NCT07226011Recruiting
Fast High-Dose Brain Stimulation for Depression
This study tests a stronger, faster type of brain stimulation (called tDCS) to see if it can help treat depression. It may be a good fit if you have major depression and haven't used other brain stimulation in the past 6 months.
Charleston, South CarolinaAges 18–70 - NCT05553353Recruiting
Repeated brain stimulation for depression after spinal cord injury
This study tests a non-drug treatment called repeated transcranial magnetic stimulation (rTMS) to reduce depression symptoms in people with depression after a spinal cord injury. You might be eligible if you have ongoing major depression and can safely receive magnetic pulses to the head.
Charleston, South CarolinaAges 18–60 - NCT05725239Recruiting
Testing vibration or magnetic stimulation for depression
This study tests whether taVNS, TMS, or both can improve depression symptoms. It may help people whose depression has not improved enough with usual treatments like antidepressant pills or talking therapy.
Charleston, South CarolinaAges 18–75 - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
North Charleston, South CarolinaAges 18–74 - NCT03887715RecruitingTeam says not enrolling
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Charleston, South CarolinaAges 18 years+ - NCT06562153Recruiting
fMRI-guided TMS for depression
This trial tests whether combining fMRI brain scans with TMS (a non-invasive brain stimulation) can help treat depression more effectively. It is for adults with major depressive disorder who can safely undergo MRI.
Charleston, South CarolinaAges 18–65 - NCT07634705Recruiting
Digital app to help manage depression in primary care
This study tests a smartphone app called Moodivate that helps treat depression through your regular doctor's office using video visits. It's designed for people with mild-to-moderate depression who want a flexible, technology-based treatment option.
Charleston, South CarolinaAges 18 years+ - NCT05977439Recruiting
Brain training for depression recovery
This study uses brain imaging and stimulation to help people with depression learn how to regulate their emotions better. It aims to find out if targeting specific brain networks can improve symptoms.
Charleston, South CarolinaAges 18–65 - NCT03417960Recruiting
Accelerated brain stimulation for postpartum depression
This trial studies an intensive form of noninvasive brain stimulation (treatments given through the scalp) for postpartum depression. It aims to reduce depression symptoms and improve wellbeing in people who are at least 18 and have moderate symptoms.
Charleston, South CarolinaAges 18–50 - NCT06930729Recruiting
Depression help for cancer survivors via video and app
This study tests a program to help cancer survivors who are feeling depressed. It uses video calls and a smartphone app called Moodivate to check in with you, and you do not have to be in therapy to join.
Charleston, South CarolinaAges 18 years+ - NCT04263285Recruiting
Repetitive brain stimulation for depression after spinal cord injury
This trial studies a brain-stimulation treatment to improve depression symptoms in people who have depression after a spinal cord injury. It may help if you have major depression and meet specific safety and eligibility checks.
Charleston, South CarolinaAges 18–70 - NCT07091968Recruiting
Text-message support for depression in cancer survivors
This study is testing a text-message program to help cancer survivors who feel depressed get connected to mental health support. The goal is to see if this simple, phone-based approach makes it easier to follow up on a referral for depression care.
Charleston, South CarolinaAges 18 years+ - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Charleston, South CarolinaAges 22–70 - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Charleston, South CarolinaAges 18–74 - NCT06582784Recruiting
Using a phone app to help cancer survivors with depression
This study tests a mobile app to help cancer survivors who are feeling depressed. If you have a smartphone and are willing to use an app for mood support, you may be able to join.
Charleston, South CarolinaAges 18 years+ - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
North Charleston, South CarolinaAges 18–65 - NCT06748209RecruitingPhase 4
Mobile TMS for treatment-resistant depression
This trial tests if delivering transcranial magnetic stimulation (TMS) through a mobile unit can help people with depression that hasn't improved with other treatments.
Charleston, South CarolinaAges 22–80 - NCT07210255Recruiting
SAINT TMS for postpartum depression
This trial tests a special type of TMS (brain stimulation) called SAINT for severe depression that started around childbirth. It may help new mothers who are still within a year postpartum and have not found relief from other treatments.
Charleston, South CarolinaAges 18–45 - NCT07369557Recruiting
Mindfulness training with TMS for depression
This trial combines mindfulness training with accelerated TMS therapy for depression. It tests if adding mindfulness helps improve treatment outcomes.
Charleston, South CarolinaAges 18–80 - NCT07372586Recruiting
Behavioral health support after ICU stay
This study tests a collaborative care model for mental health and recovery after an ICU stay. You might qualify if you visit the MUSC ICU Recovery Clinic within six months of leaving the hospital.
Charleston, South CarolinaAges 18 years+ - NCT07390786Recruiting
Family support program after ICU stay
This study tests a collaborative care program for family members of ICU recovery patients, designed to improve mental health support after a loved one's hospitalization.
Charleston, South CarolinaAges 18 years+ - NCT07002554Enrolling by invitationPhase 2
Bright light therapy for older adults with depression in the hospital
This study tests whether bright light therapy helps reduce depression in adults aged 60 and older who are hospitalized for depression. If you are currently staying on the Senior Care Unit at MUSC and have a depression diagnosis, this treatment might be an option for you.
Charleston, South CarolinaAges 60 years+
Depression trials by city in South Carolina
Where these studies are running in South Carolina
Institutions with a site for the recruiting depression studies listed above.
- Medical University of South Carolina · 17 studies
- Coastal Carolina Research Center · 2 studies
- 30 Bee Street
- Autobahn Site #128
- Clinical Trials of South Carolina
- IOP
- Medical Univeristy of South Carolina
- Medical Univerity of South Carolina
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in South Carolina?
- Yes. We're currently tracking 28 recruiting depression studies with a site in South Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in South Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in South Carolina to take part?
- Not necessarily. These studies have a site in South Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in South Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.