Clinical trials · Texas
Depression clinical trials in Texas
We’re tracking 95 recruiting depression studies with a site in Texas — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Texas
- NCT07051200Recruiting
Support program for young adults after a mental health crisis
This study offers a program to support young adults who recently faced a mental health crisis. It aims to help you recover by providing inspiration, support, and empowerment after a hospital stay.
Dallas, TexasAges 18–27 - NCT06903819RecruitingPhase 4
Ketamine for pain and mental health after orthopedic injury
This trial tests if ketamine can reduce pain, opioid use, and improve mental health in adults recovering from serious orthopedic injuries. It may help those with high injury severity scores.
Lubbock, TexasAges 18–65 - NCT06856057Recruiting
Support for caregivers and kids after injury
This study helps parents and young children cope with stress after a hospital stay for an injury. It tests a program to improve mental health for both caregivers and kids.
Houston, TexasAges 18 years+ - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Dallas, TexasAges 18–70 - NCT06748222RecruitingPhase 3
Online mindfulness program for breast cancer survivors
This trial tests a 6-week online mindfulness program to help breast cancer survivors manage mild to moderate depression. You may qualify if you finished active treatment within the last 5 years and can use a digital device.
Amarillo, TexasAges 18–50 - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Bellaire, TexasAges Any age - NCT06713616RecruitingPhase 3
Esketamine vs. ketamine for hard-to-treat depression
This study compares the effectiveness of esketamine (Spravato) and another similar drug, ketamine, for adults with major depression that has not improved after trying at least two other antidepressants. It aims to find out which treatment works better.
Bellaire, TexasAges 18 years+ - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Houston, TexasAges 18–85 - NCT06526078Recruiting
Combining brain training with ketamine for depression
This study tests if adding computer-based cognitive training to ketamine treatment can improve mood in people with depression that hasn't responded to other treatments. It aims to see if the combination works better than ketamine alone.
Houston, TexasAges 18–80 - NCT06290778Enrolling by invitation
Mental health prevention training for fire fighter trainees
This study tests a program where peers teach emotion regulation skills to help prevent mental health issues in new fire fighters. You would be asked to complete surveys and attend training sessions.
Waco, TexasAges 21 years+ - NCT06262178Recruiting
Parenting support for mothers in military families
This study tests a parenting program designed to help mothers in military families cope with past trauma and improve their relationship with their child. The program aims to reduce PTSD and depression symptoms while increasing parenting confidence.
El Paso, TexasAges 18 years+ - NCT06257095Recruiting
Phone Support Program for Older Adults Leaving APS
This study is testing a phone-based support program for older adults who have been helped by Adult Protective Services and are now moving on. College students in health fields will provide friendly, weekly check-in calls to help with social and emotional needs.
Houston, TexasAges 65 years+ - NCT06200155RecruitingPhase 2
Psilocybin therapy for advanced cancer patients with anxiety or depression
This trial tests whether a drug called psilocybin, given with therapy, can help people with advanced cancer who are feeling anxious or depressed. You must have a stable cancer and be willing to travel to Houston for treatment.
Houston, TexasAges 25 years+ - NCT06085313Recruiting
Web-based program for cancer pain in Asian women
This trial tests a web-based program to help women of Chinese, Korean, or Japanese heritage manage breast cancer pain and depressive symptoms. If you've had breast cancer, have had pain in the past week, and feel some depression, this program could help you cope better.
Austin, TexasAges 18 years+ - NCT05418894Recruiting
Study brain signals and improve treatment-resistant depression
This trial studies how brain activity relates to feelings and depression, using brain electrodes to measure signals. It’s meant for people with long-lasting, treatment-resistant major depression who may need stimulation while continuing psychiatric care.
Houston, TexasAges 22–70 - NCT06034821Enrolling by invitationPhase 4
ECT vs. ketamine for suicidal depression in adults
This trial compares two treatments—ECT (electroconvulsive therapy, which uses electrical stimulation) and ketamine (a medicine given as a shot)—to see which works better for quickly reducing suicidal depression. It is for adults who are in a severe depressive episode with active suicidal thoughts.
Houston, TexasAges 18–90 - NCT05871372Recruiting
Study brain circuits behind mood using brain monitoring
This study looks at how brain networks relate to mood and depression by recording brain activity during specific procedures. You may be able to join if you’re already having brain monitoring for epilepsy or are part of a depression deep brain stimulation program.
Houston, TexasAges 21–70 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
DeSoto, TexasAges 18 years+ - NCT05809115Recruiting
Caregiver-child bonding support for hospitalized young children
This study looks at how a caregiver and their young child bond during a hospital stay, and whether extra support can help. It may help families feel more connected and supported while their child is in the hospital.
Houston, TexasAges 18 years+ - NCT05752448Recruiting
Care plan support for women after ovarian cancer treatment
This trial looks at survivorship care—how to help women after ovarian cancer treatment. It may improve follow-up planning and support during the first months after treatment ends.
Dallas, TexasAges 18 years+ - NCT05563805Recruiting
Virtual reality adventure training for movement and fitness
This study uses a virtual reality “adventure” game that gets you moving to train exercise skills and coordination. It’s designed for U.S. military veterans who can walk on their own and don’t have certain vision, balance, or medical limits.
Arlington, TexasAges 18–45 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT03906435Recruiting
Cognitive therapy to prevent problems for very premature NICU babies
This study offers a counseling approach to help prevent “Vulnerable Child Syndrome” in babies born very early and cared for in the NICU. It focuses on support during the early months after birth and compares outcomes for families getting the therapy versus usual support.
Dallas, TexasAges Any age
Depression trials by city in Texas
Where these studies are running in Texas
Institutions with a site for the recruiting depression studies listed above.
- Baylor College of Medicine · 3 studies
- Houston Center for Advanced Psychiatric Treatment · 2 studies
- The University of Texas Health Science Center at Houston · 2 studies
- Adams Clinical
- Adams Clinical, Dallas
- Dallas Renal Group
- Dan L Duncan Comprehensive Cancer Center at the O'Quinn Medical Tower at Baylor St. Luke's Medical Center
- Harris Health Smith Clinic
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression trials in other states
Common questions
- Are there depression clinical trials in Texas?
- Yes. We're currently tracking 95 recruiting depression studies with a site in Texas, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study in Texas?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Texas to take part?
- Not necessarily. These studies have a site in Texas, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open in Texas regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.