Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05691647Recruiting
Testing timing-based treatment for a new depressive episode
This trial studies whether “chronotherapy” (carefully timing daily activities/therapies) can help people with a new moderate to severe depression episode. You may be eligible if your depression is recent and fairly severe, and if your daily schedule can support the timing plan.
TrondheimAges 18–100 - NCT06728280Recruiting
DTMS for teens with depression: safety and effectiveness
This trial tests if a new type of brain stimulation called DTMS can safely help adolescents with major depression. It may be an option if you have tried other treatments and are looking for a non-medication approach.
Taiyuan, ShanxiAges 11–23 - NCT06671977RecruitingPhase 1
Safety and effects of DMT in healthy adults and those with depression
This trial studies the safety and effects of DMT, a psychedelic compound, in healthy volunteers and people with major depressive disorder (MDD) who haven't responded well to antidepressants. It aims to see how DMT affects the brain and mood.
West Haven, ConnecticutAges 21–65 - NCT06385223Recruiting
Personalized brain stimulation for hard-to-treat depression
This study tests a new, personalized form of brain stimulation (called TMS) using MRI scans to target the right areas for people whose depression hasn't improved with medication. It aims to see if this tailored approach works better than standard TMS.
SingaporeAges 21 years+ - NCT06971549Recruiting
Faster TMS for depression with brain monitoring
This study tests a faster version of TMS (called iTBS) to treat depression, while using a special headband to monitor brain blood flow in real time. It's for people whose depression hasn't gotten better with at least one antidepressant medication.
Hong KongAges 18–65 - NCT06626425Recruiting
Well-being training for teens with depression
This study tests a 4-week well-being training program to see if it helps teens feel better and manage depression. You would use a smartphone app and answer surveys to track your mood and well-being.
Madison, WisconsinAges 14–19 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06508710RecruitingPhase 3
Ketamine plus venlafaxine for severe depression
This trial tests whether adding ketamine to the antidepressant venlafaxine helps relieve severe depression faster than venlafaxine alone. If you are hospitalized for a serious depression and you meet safety criteria, you may be eligible.
Le Kremlin-Bicêtre, FranceAges 18–65 - NCT06716034Recruiting
Mood and diet pilot trial for teens with depression
This study tests whether a special diet can help improve mood in teens with depression. You and your parent will work together online with the study team.
Toronto, OntarioAges 11–17 - NCT07464886RecruitingPhase 3
NAC and mindfulness therapy for depression in youth
This study tests whether a supplement called N-acetylcysteine (NAC) combined with a type of therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help improve depression in teenagers and young adults. It looks at how these treatments affect brain chemicals and may reduce symptoms.
Cincinnati, OhioAges 15–24 - NCT06997549Recruiting
Review of mental health treatment outcomes
This study looks back at information from a large database of people who received mental health treatments. It aims to understand how well treatments worked and what factors influenced outcomes.
Malvern, PennsylvaniaAges 5–100 - NCT07655232Recruiting
Behavioral program for depression in nursing homes
This study tests a behavioral program designed to help skilled nursing facility residents with depression. The program aims to improve mood and quality of life.
Boston, MassachusettsAges 18 years+ - NCT06017622Recruiting
THC Levels in Young People with Cannabis Overdose in the ER
This study looks at the amount of THC (the active ingredient in cannabis) in the blood of children and teens who come to the emergency room with severe drowsiness or confusion after using cannabis. It will help doctors better understand how cannabis affects young people.
Worcester, MassachusettsAges Any age - NCT07422909Enrolling by invitation
Bridging the gap: adding exercise to depression treatment for teens
This trial tests if adding physical activity to standard depression care helps teens feel better. It's for teens ages 12 to 19 in Brussels who are not very active now.
Brussels, UccleAges 12–19 - NCT06294184Recruiting
Brain stimulation for mild depression in young people
This trial tests a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) to see if it can help young people with mild depression symptoms. It is designed for those who have some depressive feelings but do not yet meet the full criteria for major depression.
Guangzhou, GuangdongAges 12–25 - NCT06597695RecruitingPhase 1/Phase 2
Ketamine group therapy for Spanish-speaking adults with depression
This trial tests whether ketamine-assisted group therapy can help Spanish-speaking Latinx adults with major depression. You would receive ketamine in a supportive group setting, with the goal of improving your mood and quality of life.
Chelsea, MassachusettsAges 18–64 - NCT07423273Recruiting
Hyperbaric oxygen therapy for post-stroke depression
This study tests if breathing pure oxygen in a special chamber (hyperbaric oxygen therapy) can help people who have been depressed since having a stroke. It may offer a new way to treat depression that hasn't improved with standard medications.
ZrifinAges 50–85 - NCT06266715Recruiting
Testing ATP for depression relief
This trial tests if a natural compound called ATP can help improve moderate to severe depression symptoms. If you haven't taken antidepressants recently and have never tried escitalopram, you may be eligible.
Guangzhou, GuangdongAges 18–65 - NCT05691439Recruiting
Sleep Timing, Mood, and Brain Circuits in Teens With Depression
This study looks at how sleep timing affects brain function related to mood and “pleasure” in teenagers who have depressive symptoms. It may help researchers understand why depression and reduced interest/pleasure can happen, and how sleep patterns might be a key factor.
Eugene, OregonAges 14–18 - NCT05648175Recruiting
Test an AI coaching tool versus a care team for depression
This study compares an artificial intelligence (AI) decision-making approach with support from a multi-professional care team for treating depression. It aims to see which approach helps people make better treatment choices and manage symptoms.
Kingston, OntarioAges 18 years+ - NCT06424184Recruiting
Fast brain stimulation for addiction and depression
This study tests a quick, non-invasive brain stimulation method (rTMS) to help people who use stimulants like cocaine or methamphetamine and also feel depressed. The goal is to see if it can reduce cravings and improve mood.
Dallas, TexasAges 18–65 - NCT07373080Recruiting
Behavioral activation therapy for adults with depression
This trial tests a culturally adapted behavioral activation therapy to help adults with depression in primary care settings. It aims to improve both effectiveness and implementation of the therapy.
Sleman, Special Region of YogyakartaAges 18–65 - NCT07449676Recruiting
Tui Jing therapy for depression study
This study tests a gentle hands-on therapy based on Traditional Chinese Medicine, called Tui Jing, to see if it improves mood and brain function in people with depression. It lasts 12 weeks and compares the therapy with a placebo.
Hong Kong, Hung HomAges 18–55 - NCT06557525RecruitingPhase 1/Phase 2
Neurofeedback for depression: a research study
This early-phase trial tests whether a brain-training technique called neurofeedback can help reduce depression symptoms. It is for adults with major depression who are not at high risk for suicide or addiction.
FukuokaAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.