Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06424184Recruiting
Fast brain stimulation for addiction and depression
This study tests a quick, non-invasive brain stimulation method (rTMS) to help people who use stimulants like cocaine or methamphetamine and also feel depressed. The goal is to see if it can reduce cravings and improve mood.
Dallas, TexasAges 18–65 - NCT07373080Recruiting
Behavioral activation therapy for adults with depression
This trial tests a culturally adapted behavioral activation therapy to help adults with depression in primary care settings. It aims to improve both effectiveness and implementation of the therapy.
Sleman, Special Region of YogyakartaAges 18–65 - NCT07449676Recruiting
Tui Jing therapy for depression study
This study tests a gentle hands-on therapy based on Traditional Chinese Medicine, called Tui Jing, to see if it improves mood and brain function in people with depression. It lasts 12 weeks and compares the therapy with a placebo.
Hong Kong, Hung HomAges 18–55 - NCT06557525RecruitingPhase 1/Phase 2
Neurofeedback for depression: a research study
This early-phase trial tests whether a brain-training technique called neurofeedback can help reduce depression symptoms. It is for adults with major depression who are not at high risk for suicide or addiction.
FukuokaAges 18 years+ - NCT06400121RecruitingPhase 2
Apimostinel plus brain training for depression
This study tests if a new drug called apimostinel, combined with computer-based brain training exercises, can improve depression symptoms. It may help people with major depression who also have negative thoughts about themselves.
Pittsburgh, PennsylvaniaAges 18–60 - NCT05681767Recruiting
Lifestyle coaching to support depression care in primary clinics
This trial studies whether motivational, multi-part lifestyle coaching can help adults with depression when they start treatment through a regular primary care clinic. If you’re eligible, the program may add supportive skills to help improve mood alongside usual care.
KuopioAges 18 years+ - NCT07333027Recruiting
Loneliness in depression treatment study
This study looks at how loneliness affects people hospitalized for depression. It may help researchers understand how to better support recovery.
Erlangen, BavariaAges 18 years+ - NCT06797804Recruiting
Horticultural therapy for older adults in long-term care
This study tests if an app-guided gardening program can improve heart health, reduce stress and depression, and boost happiness in older adults living in nursing homes. It aims to see if these sessions can help you feel better overall.
TaipeiAges 65 years+ - NCT05456035Recruiting
Talk-therapy plus social skills training for depressed teens
This study tests whether adding social-cognitive training (skills for understanding social situations and thoughts) to regular talk therapy helps teens with depression. It may help improve mood and daily functioning compared with talk therapy alone.
Nashville, TennesseeAges 13–17 - NCT05570721Recruiting
Study of depression, stress, and heart health in late menopause
This study looks at how depression and stress connect to heart health in women going through the late stages of menopause. It may help researchers understand what factors affect heart risk during this life stage, including how symptoms and daily life relate to heart measurements.
Chapel Hill, North CarolinaAges 44–55 - NCT07293806Recruiting
Dance therapy for teens with depression
This study tests whether dance-movement therapy (moving with a therapist to express feelings) can help teens with moderate to severe depression feel better. It is for adolescents who are not experiencing other severe mental health conditions like psychosis or a critical substance use problem.
HelsinkiAges 13–17 - NCT04142996Recruiting
Comparing one- vs two-side brain stimulation for depression
This trial compares two versions of a noninvasive brain treatment called rTMS to see which side-to-side approach works better for major depression. You may be eligible if you still have moderate depressive symptoms despite trying at least one antidepressant.
Ottawa, OntarioAges 18 years+ - NCT06966921Recruiting
Brain stimulation for thinking, mood, and sleep in mental illness
This trial tests if a gentle electrical device placed on your head (cranial electrotherapy) can improve thinking, mood, and sleep for people living with chronic mental health conditions. It's a non-invasive approach that might help with anxiety or depression without medication side effects.
Nantou CityAges 20–75 - NCT07227389Recruiting
Opioid Timing and Breathing Risk After Surgery
This study looks at when opioids are given during surgery and how it affects breathing problems after surgery. It might help understand how to make pain control safer.
Detroit, MichiganAges 18–85 - NCT06517121Recruiting
Brain stimulation for mild depression
This trial tests whether a gentle brain stimulation technique called tDCS can help people with mild depression symptoms. It aims to improve mood without the need for medication.
Hong KongAges 18 years+ - NCT07239011RecruitingPhase 1/Phase 2
Dapagliflozin for depression study
This trial tests whether dapagliflozin, a diabetes medication, can help treat major depression. It is for adults who have been depressed for at least 2 months and score high on a depression scale.
Damietta, New DamiettaAges 18–60 - NCT07198438Enrolling by invitation
Deep vs standard brain stimulation for depression
This trial compares two types of brain stimulation (deep vs standard theta burst stimulation) to see which works better for people with depression who haven't gotten enough help from antidepressant medication. It aims to find a more effective treatment option.
Douliu, Yunlin CountyAges 18–70 - NCT07163013Recruiting
Digital therapy for teens with depression
This trial tests a digital therapy (a phone- or computer-based program) that teaches you skills to manage depression. It is designed for Chinese-speaking teens who have moderate to severe depression and are not currently receiving other treatment.
ChongqingAges 12–18 - NCT07118072Recruiting
Online therapy for childhood trauma and depression symptoms
This study will test if a special online therapy program, called i-STAIR, can help people who had a tough childhood and are now dealing with some depression symptoms. It focuses on building skills to manage emotions and relationships, all from the comfort of your home.
SingaporeAges 21–65 - NCT06565936Recruiting
PET/MRI brain scans for understanding depression
This trial uses two special brain scans (DPA-714 and FDG PET/MRI) to look at inflammation and brain activity in people with first-episode or recurrent depression, and in healthy volunteers. It aims to find brain differences that could lead to better treatments.
Dalian, LiaoningAges 35–85 - NCT07064551Recruiting
Combining medical and community support for depression
This study tests a new way of combining medical care with community support for middle-aged and older adults who have depression and are waiting for mental health services. The goal is to see if this team approach can help improve mood and well-being while you wait.
Hong KongAges 45 years+ - NCT06580249Recruiting
Brain stimulation for pleasure loss in teen depression
This trial tests if repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation, can help teenagers with depression who have lost interest or pleasure in things they used to enjoy.
Xi'an, ShaanxiAges 10–19 - NCT06867549RecruitingPhase 2
Propofol for depression in older adults
This study tests if a medicine called propofol (given through an IV) can help improve depression symptoms by boosting slow brain waves during sleep. It is for people 60 and older whose depression has not fully responded to standard antidepressants.
St Louis, MissouriAges 60 years+ - NCT03276793Recruiting
Brain connectivity study in people with depression
This study looks at brain “connectivity” (how different brain areas talk to each other) in people with depression. You may be able to join if you are already getting once-daily TMS to a specific brain area at Brigham and Women’s or Massachusetts General, and you can safely complete MRI scans.
Boston, MassachusettsAges 18 years+
Hear when a new Depression trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,509 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.