Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06278779RecruitingPhase 4
Comparing two types of ketamine for stubborn depression
This study compares two forms of ketamine to see which works better for depression that hasn't improved with at least two other antidepressants. If you've tried multiple antidepressants without success, this trial might help find a more effective treatment.
Camperdown, New South WalesAges 18 years+ - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT06253390Recruiting
New cognitive therapy for postpartum depression
This trial tests a new type of talk therapy for women who have given birth and are experiencing depression. It aims to see if this treatment can help improve their mood and well-being.
ReimsAges 18–45 - NCT06263738Recruiting
Cold and heat therapy for depression
This trial tests if carefully controlled cold or heat exposure can help lower symptoms of depression. It is open to people with or without depression to see how the body responds to changes in temperature.
Edwards, ColoradoAges 18–65 - NCT06263660RecruitingPhase 2
Keto supplement for depression with inflammation
This study tests a keto-like supplement to see if it helps change how the brain responds to emotional situations in people with depression and higher inflammation. It involves MRI brain scans and blood tests.
Tulsa, OklahomaAges 18–65 - NCT04069091Recruiting
Program to help mothers with depression during pregnancy or after birth
This trial studies a maternal depression prevention and early help program for people who screen positive for depression. It may help improve mental health during pregnancy or the postpartum period and support health for both parent and child.
Helsinki, UusimaaAges Any age - NCT06247839RecruitingPhase 3
Psilocybin for depression: changing self-focus
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
Charlestown, MassachusettsAges 18–55 - NCT06238700Recruiting
Studying allopregnanolone for depression in midlife women
This trial tests whether allopregnanolone, a natural brain chemical, can help depression in women going through menopause. It compares the effects against a placebo to see if it improves mood symptoms.
Boston, MassachusettsAges 40–60 - NCT06231602Recruiting
Depression and feeding in new mothers
This study looks at how a mother's mood after giving birth might affect how she feeds her baby. It aims to help first-time mothers get better support.
TaipeiAges 18 years+ - NCT06234371Enrolling by invitation
Financial rewards for veterans finishing therapy
This trial tests whether offering money helps veterans stick with their counseling sessions. If you're a veteran in individual therapy, you may be able to earn financial incentives for completing your treatment.
Dallas, TexasAges 18 years+ - NCT06217198Recruiting
Computerized depression program for veterans
This trial tests a computer-based program to help veterans with mild to moderate depression. It aims to see if the program can improve mood and is accessible online.
Waco, TexasAges 18 years+ - NCT06188923RecruitingPhase 2
Pregnenolone for anxiety and depression in veterans
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Durham, North CarolinaAges 18–65 - NCT06203899Recruiting
Depression and suicide prevention for teens in special schools
This study tests a program to prevent depression and suicide in teens at special schools. It helps if you've had some symptoms but aren't already getting treatment.
Boekel, Noordoost BrabantAges 12–18 - NCT06162624Recruiting
Workbook to help with anxiety and depression in prison
This study is testing a special workbook that helps people in prison manage tough emotions like anxiety and depression using a technique called ACT (Acceptance and Commitment Therapy). The workbook is designed to be used on your own, and the study wants to see if it can help you feel better.
Madison, WisconsinAges 18 years+ - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+ - NCT06132581Recruiting
Brain stimulation for pleasure loss in depression
This study tests a new type of brain stimulation to see if it can help people with depression who have lost the ability to feel pleasure. It uses MRI scans to guide the treatment and may help improve motivation and goal-setting.
Tallahassee, FloridaAges 18–65 - NCT06145555Enrolling by invitation
Sleep stabilization therapy for hospitalized depression
This study tests a quick, non-drug sleep therapy for people in the hospital for depression. It aims to help stabilize your sleep to improve your mood and recovery.
StockholmAges 18 years+ - NCT06145984Recruiting
Positive Thinking Techniques to Prevent Depression Relapse
This study tests whether positive thinking exercises help people who have recovered from depression stay well and avoid relapse. Researchers will compare people with a history of depression to those who've never had depression to understand how these techniques work.
Groningen, Provincie GroningenAges 18–60 - NCT06110897Recruiting
Resistance Exercise for Depression Trial
This study tests whether resistance exercise (like lifting weights) can help reduce depression symptoms. If you have major depression and are not already doing regular resistance training, you may be able to join.
Ames, IowaAges 18–65 - NCT05630963Recruiting
Study sleep-like brain signaling in major depression
This trial looks at how a specific brain receptor related to pain signals (nociceptin/orphanin FQ receptor) may be involved in depression. It may help researchers understand depression better by comparing people with current versus past (remitted) major depression.
Belmont, MassachusettsAges 18–45 - NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT03364803Recruiting
Sharing treatment results for people with Cushing’s syndrome
This is a study that collects and reviews information about how people with Cushing’s syndrome (including some mild forms and certain “silent” tumors) are diagnosed and treated, and what outcomes they have. It may help researchers understand which treatments work best in different types of the condition.
Basking Ridge, New JerseyAges 14 years+ - NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT06095310Recruiting
Understanding severe depression in hospitalized patients
This study looks at the clinical and psychiatric features of severe depression in adults who are hospitalized. It aims to better understand the condition and improve care.
LilleAges 18 years+
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.