Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06455293RecruitingPhase 2
Psilocybin therapy for depression in Parkinson's disease
This study tests whether psilocybin, a substance found in certain mushrooms, can help improve depression in people with Parkinson's disease. If you have Parkinson's and are feeling depressed, this treatment may offer a new option.
San Francisco, CaliforniaAges 40–80 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06445933Recruiting
Vitamin B6 for depression in pregnancy and after birth
This trial tests whether taking Vitamin B6 can help prevent depression in pregnant women and new mothers. If you are between 24 and 28 weeks pregnant and have no history of mental health conditions, you may be able to join.
TaipeiAges 20–50 - NCT06361095RecruitingEarly Phase 1
Brain training for depression: attention bias modification trial
This trial tests a computer-based brain training program designed to change how you pay attention to emotional information. It may help reduce depression symptoms by training your brain to focus less on negative cues.
Austin, TexasAges 18–70 - NCT06424184Recruiting
Fast brain stimulation for addiction and depression
This study tests a quick, non-invasive brain stimulation method (rTMS) to help people who use stimulants like cocaine or methamphetamine and also feel depressed. The goal is to see if it can reduce cravings and improve mood.
Dallas, TexasAges 18–65 - NCT06429956Recruiting
Combined online therapy for anxiety and depression
This trial tests a new type of therapy that combines different treatment methods for anxiety and depression. It is completely online, so you can join from home, and it aims to help you feel better by tailoring the therapy to your needs.
AarhusAges 18 years+ - NCT06430333RecruitingPhase 2
Sleep therapy to prevent depression in pregnancy
This study tests whether a sleep-focused therapy can help prevent depression in pregnant people who have insomnia. If you are 14–31 weeks pregnant and have trouble sleeping, this trial offers a program to improve your sleep and lower your risk of depression.
Novi, MichiganAges 18 years+ - NCT06419439RecruitingPhase 2
Ketamine for Veterans with Chronic Back Pain and Depression
This study tests whether ketamine, combined with talk therapy, can help veterans with both chronic low back pain and depression. The goal is to reduce pain and improve mood.
Ann Arbor, MichiganAges 18 years+ - NCT06412315Recruiting
Brain scan study of emotion and a common antidepressant
This study uses a powerful MRI scanner to look at how a part of the brain called the amygdala responds to emotional tasks, and whether a common antidepressant called citalopram affects that response. It may help researchers understand how these treatments work for mental health conditions.
Oxford, OxfordshireAges 18–40 - NCT06402955RecruitingPhase 2
Imaging depression in Parkinson's disease
This study uses brain imaging (PET scans) to understand depression in people with Parkinson's disease. It may also test a depression treatment called ketamine, but the main goal is to see how the brain changes with depression.
New Haven, ConnecticutAges 40–80 - NCT06400121RecruitingPhase 2
Apimostinel plus brain training for depression
This study tests if a new drug called apimostinel, combined with computer-based brain training exercises, can improve depression symptoms. It may help people with major depression who also have negative thoughts about themselves.
Pittsburgh, PennsylvaniaAges 18–60 - NCT06408246RecruitingPhase 2
Cognitive training and medication for depression
This study tests whether a combination of cognitive training (brain exercises) and a medication (guanfacine or sertraline) can improve thinking skills in people with depression. It involves MRI scans and computer tasks to understand how your brain responds.
Palo Alto, CaliforniaAges 18–60 - NCT06384196Recruiting
Virtual-reality therapy for anxiety and depression in young people
This study tests a new virtual-reality therapy for young people struggling with anxiety or depression. It aims to help you feel better by addressing both conditions together.
BadalonaAges 16–29 - NCT06389175Enrolling by invitation
Non-invasive ear stimulation for depression
This study uses a gentle, non-invasive device that stimulates the vagus nerve in your ear to see if it can improve how your stomach and brain communicate, which may help with depression symptoms.
BonnAges 18–55 - NCT06384209Recruiting
Friendship Bench Plus for Depression
This study tests whether a structured talk therapy program called the Friendship Bench can help adults with moderate to severe depression. You will have conversations with trained lay counselors who guide you through problem-solving techniques.
HarareAges 18 years+ - NCT06383221Enrolling by invitation
Psychological and prenatal support for depression or anxiety in pregnancy
This trial tests a step-by-step program that combines psychological support and prenatal care to help pregnant women manage depression or anxiety. It is designed for women who have screened positive for these symptoms but are not yet receiving treatment.
Ma’anshanAges 18 years+ - NCT05681767Recruiting
Lifestyle coaching to support depression care in primary clinics
This trial studies whether motivational, multi-part lifestyle coaching can help adults with depression when they start treatment through a regular primary care clinic. If you’re eligible, the program may add supportive skills to help improve mood alongside usual care.
KuopioAges 18 years+ - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Dothan, AlabamaAges 10–17 - NCT06376734RecruitingPhase 2
TMS for depression, anxiety, OCD, or schizophrenia
This study tests whether a brain stimulation technique called TMS can help people with depression, anxiety, OCD, or schizophrenia. It aims to find better ways to target the treatment for each person's specific needs.
Sunnyvale, CaliforniaAges 18–65 - NCT06370988Recruiting
Theta-burst stimulation for bipolar depression
This study tests a type of brain stimulation (theta-burst TMS) to see if it helps improve depression in people with bipolar disorder. It might be a good option if you have tried medication but still feel depressed.
Toronto, OntarioAges 18–65 - NCT06345859RecruitingPhase 2
Brain and emotion study for young adults with or without depression history
This study looks at how the brain regulates mood and body signals in young adults ages 18-27. It includes people who have had depression in the past but are now well, as well as healthy volunteers with no psychiatric history.
Los Angeles, CaliforniaAges 18–27 - NCT06355414RecruitingPhase 1
Psilocybin for chronic back pain and depression
This trial tests if psilocybin, a psychedelic drug, can help people with long-term low back pain who also have depression. If you qualify, you'll receive psilocybin in a controlled setting, and researchers will see how it affects your pain and mood.
Baltimore, MarylandAges 21–80 - NCT06295250Recruiting
Help for depression and poverty in Bangladesh
This study tests a program in Bangladesh that helps people with depression and poverty. You and your family would work together to improve your mood and financial situation over 18 months.
Dhaka, Dhaka DivisionAges 18–45 - NCT05239780Recruiting
Brain stimulation study for adults with depression
This study uses an invasive approach (placement of brain monitoring/stimulation) to better understand how the brain processes reward in depression. It may help researchers develop more targeted treatments in the future.
New York, New YorkAges 18–80
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.