Clinical trials
Depression clinical trials
A common mood disorder causing persistent sadness and loss of interest. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07219394Recruiting
Peer support for depression in community care
This trial tests if peer-delivered behavioral therapy can help adults with depression symptoms. If you are 18 or older and feel sad or down, this study may teach you practical ways to feel better.
Detroit, MichiganAges 18 years+ - NCT07219875RecruitingPhase 2
Virtual reality training for depression
This study tests a virtual reality program that may help people with depression feel more rewarded by positive experiences. It uses exercises designed to improve how your brain responds to rewards, which could help reduce depressive symptoms.
Los Angeles, CaliforniaAges 18 years+ - NCT07220486Recruiting
Depression support program for nursing home residents and their helpers
This study tests a program for nursing facility residents who have symptoms of depression and their care partners. It aims to provide emotional and practical support during a short stay.
Boston, MassachusettsAges 18 years+ - NCT06413849Recruiting
Phone coaching with a picture-story book for dementia caregivers
This study tests if talking with a coach by phone and reading a story-based book can help family caregivers of people with dementia feel better. You'll get a free book and weekly coaching calls to help manage your mood.
Hong Kong SARAges 18 years+ - NCT04900064Recruiting
Self-help CBT added to primary care behavioral health
This trial studies whether adding a Swedish self-help version of “CBT” (a structured talking-therapy approach) improves care for adults getting behavioral health support in primary care. It may help people who want support for mental health without needing fully guided therapy sessions.
Varberg, Halland CountyAges 18 years+ - NCT06250842Recruiting
Benzodiazepine impact on brain function study
This study uses brain scans to understand how long-term benzodiazepine use affects thinking and memory. It compares people who have taken benzodiazepines for at least 3 months with those who have not.
Dalian, LiaoningAges 18–80 - NCT06922409Recruiting
Light therapy for stroke recovery in rehabilitation
This trial tests whether exposure to naturalistic light can help reduce fatigue and depression after a stroke. It is designed for patients in a rehabilitation unit who are able to communicate and cooperate with simple physical exams.
Glostrup Municipality, Capital RegionAges 18 years+ - NCT07211217Recruiting
Time-restricted eating for bipolar depression
This study tests if eating only during a specific daily window can help with weight loss and mood in people with bipolar disorder who are currently depressed and overweight.
Boston, MassachusettsAges 18–65 - NCT07208851Recruiting
Booster session for mental health support in the Bahamas
This trial tests a short booster session for a mental health support program called Problem Management Plus. It may help adults in the Bahamas who are struggling with daily life but don't have severe mental health conditions.
Freeport, Grand BahamaAges 18 years+ - NCT06938373Recruiting
A test for breast cancer patients with possible depression
This study tests a new detection method for depression in people with breast cancer. It uses samples like blood, stool, and saliva to find a link between breast cancer and depression.
Changsha, HunanAges 18–80 - NCT07193823Recruiting
Sexual function study for women with MS
This study looks at sexual health in women with relapsing-remitting multiple sclerosis. It aims to understand how MS might affect sexual function and to find ways to help.
Izmir, BornovaAges 25–50 - NCT07198100Recruiting
Ear stimulation, motivation, and insulin sensitivity in depression
This study explores how a gentle electrical stimulation of the ear might affect mood, motivation, and insulin sensitivity in people with and without depression. It aims to see if this non-invasive technique could offer new ways to help with depression.
BonnAges 18–60 - NCT07198542Enrolling by invitation
Vagus nerve stimulation for somatic symptom disorder
This trial tests if gentle electrical stimulation on the vagus nerve in the ear or neck can help reduce physical symptoms that are closely linked to stress. It is for adults with somatic symptom disorder who are on stable medications.
Douliu, YunlinAges 18–65 - NCT05867849RecruitingPhase 3
Cannabidiol treatment for bipolar depression symptoms
This trial tests whether cannabidiol (CBD) can reduce symptoms of bipolar depression. You may be eligible if you have bipolar I or II and a current depressive episode while staying on approved mood-stabilizing or antipsychotic medication.
Vancouver, British ColumbiaAges 19–70 - NCT06109493Recruiting
Psychological support for kidney dialysis patients
This trial tests a type of talk therapy (ACT) to see if it helps patients on dialysis feel better emotionally. It may be a good fit if you're on dialysis, feeling distressed, and not taking antidepressants.
MadridAges 18 years+ - NCT07185815RecruitingPhase 1/Phase 2
Study of a long-acting cariprazine shot for mood and schizophrenia
This trial tests a monthly injection of cariprazine (a medication for mental health conditions) in people who could benefit from it. It aims to see if the shot is safe, tolerable, and effective compared to taking pills every day.
AhmedabadAges 18–64 - NCT07188467Recruiting
Stress and well-being support for international students
This study tests a self-help program called 'SH+' designed to reduce stress and improve well-being in international students at The New School. If you are an international student feeling at least mildly distressed, this program may help you develop coping skills.
Brooklyn, New YorkAges 18 years+ - NCT07186816Recruiting
Peer support for Spanish-speaking adults with anxiety or depression
This trial tests whether peer support from someone who has been through similar struggles can help reduce anxiety and depression symptoms. It's for Spanish-speaking adults who have internet access and are not currently in talk therapy.
San Francisco, CaliforniaAges 18–100 - NCT07183826Recruiting
Online mindfulness therapy for chronic tinnitus
This trial tests an online mindfulness program (iMBCT) to help people with chronic tinnitus manage their symptoms. If you have had tinnitus for at least 3 months and it bothers you, you may be able to join from home.
WarsawAges 18 years+ - NCT07176403Recruiting
Exercise During Dialysis for Better Sleep and Mood
This study tests whether gentle exercise during your regular dialysis sessions can improve sleep quality, reduce feelings of depression, and lower anxiety. If you are on dialysis and are generally physically able to move your legs, this may be a safe and helpful program for you.
AlexandriaAges 18 years+ - NCT07178873Recruiting
Online support program for adults with spina bifida
This study tests an online support program for adults with spina bifida to help with emotional and social well-being. It is done from home through video calls.
Bilbao, BizkaiaAges 18–75 - NCT07172607Recruiting
Can Avnace eZZe improve sleep?
This study tests a dietary supplement called Avnace eZZe to see if it helps improve sleep in adults with insomnia. You may be able to join if you have a diagnosis of insomnia and are not currently using sleep aids.
TaipeiAges 18 years+ - NCT07173205Recruiting
Coping toolkit for teens and young adults after cancer
This trial tests a mobile toolkit to help teens and young adults manage their emotions and cope better after finishing cancer treatment. It is designed for those who completed treatment 1 month to 5 years ago.
Greenville, North CarolinaAges 15–39 - NCT07170657Recruiting
Teen Recovery Support Program
This program helps teens ages 15 to 18 who have recently been in the hospital or emergency room for suicidal thoughts or depression. It provides support and guidance to help you recover and feel stronger.
Dallas, TexasAges 15–18
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Common questions
- Are there clinical trials for depression?
- Yes. Clin2 currently lists 1,419 recruiting depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.