Clinical trials
Depressive Disorder clinical trials
Below are recruiting depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 689 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07026461RecruitingPhase 4
TMS for depression: comparing two brain stimulation methods
This trial compares two types of transcranial magnetic stimulation (TMS) to see which works better for people with depression. TMS uses magnetic pulses to stimulate brain areas involved in mood regulation.
ÖrebroAges 18 years+ - NCT07757997Recruiting
Recovery and work after stress treatment
This study checks how people who completed a hospital program for stress-related issues are doing over time, focusing on their health and ability to work. It aims to understand the long-term effects of the treatment.
SüsAges 18–80 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Huntsville, AlabamaAges 18 years+ - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Chino, CaliforniaAges 18 years+ - NCT07592689RecruitingPhase 3
DT120 Treatment for Major Depression
This study tests whether a new medication called DT120 can help people with moderate-to-severe depression feel better. You'd take the medication for several weeks while doctors track your mood and symptoms.
Little Rock, ArkansasAges 18–74 - NCT07281729Enrolling by invitation
Suicide risk factors study for mood disorders
This study looks at why some people with mood disorders (like depression or bipolar disorder) think about or attempt suicide. By finding the risk factors, doctors hope to better prevent suicide. The study involves filling out questionnaires.
Shanghai, Shanghai MunicipalityAges 16–60 - NCT06966401RecruitingPhase 3
Long-term safety study of a new depression treatment
This study tests a new oral medication (NBI-1065845) added to your current antidepressant to see if it's safe and tolerable over a long period for people with depression that hasn't fully responded to treatment.
Huntsville, AlabamaAges 18 years+ - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Oceanside, CaliforniaAges 18 years+ - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT06408012Recruiting
Master platform for mood disorder trials
This trial creates a flexible platform to test new treatments for mood disorders like bipolar disorder and depression. It also includes healthy volunteers as a comparison group.
Calgary, AlbertaAges 16 years+ - NCT05757791RecruitingPhase 2
Testing an SGLT2 diabetes drug for depression
This Phase 2 trial tests whether an SGLT2 medicine (like empagliflozin) can reduce symptoms of major depression. It may help people with moderate-to-severe depression who are otherwise eligible for the study.
New York, New YorkAges 18–65 - NCT06311136Recruiting
Mood support through a smartphone app
This trial tests a smartphone-based program designed to help people manage their emotions in the moment. It may be especially helpful if you currently have mild to moderate depression.
HeidelbergAges 18–65 - NCT06517589Recruiting
A new talk therapy for hard-to-treat anxiety and depression
This study tests a new type of talk therapy called 'process-based therapy' for people whose anxiety or depression has not gotten better with at least two prior treatments. The goal is to see if this approach can help when standard treatments have not worked.
Frankfurt am Main, HesseAges 18–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Birmingham, AlabamaAges 18–65 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Little Rock, ArkansasAges 18 years+ - NCT06856161Recruiting
Blood test to help diagnose mental health conditions
This study is testing a new blood test that might help doctors better understand and diagnose conditions like depression, psychosis, or schizophrenia. If you are 19 or older and have one of these conditions, you may be able to join.
New Westminster, British ColumbiaAges 19 years+ - NCT07022171Recruiting
Ear stimulation for depression
This study tests if a gentle electrical device worn on the ear can help improve depression symptoms. It uses a non-invasive method to stimulate the vagus nerve, which may affect mood.
MunichAges 18–65 - NCT07129941Recruiting
Unified group therapy for anxiety and depression
This study tests a group therapy program for adults aged 18-40 with anxiety or depression. It aims to help people learn skills to manage their emotions and symptoms together in a supportive group setting at a university clinic.
Bergen, VestlandAges 18–40 - NCT07228468Recruiting
Home brain stimulation for depression
This trial tests if a gentle electrical current applied to the head at home can help reduce symptoms of major depression. You would use a device for short sessions over several weeks, while continuing your usual care.
CardiffAges 18 years+ - NCT07329673Recruiting
Testing QbMobile app for ADHD-like symptoms
This trial uses an iPhone app called QbMobile to help tell the difference between ADHD and other conditions like autism, depression, bipolar disorder, or anxiety. It may help people who are not currently being treated for these conditions.
Miami, FloridaAges 6–60 - NCT05527509Recruiting
Study of risk and resilience in new RCMP cadets
This study follows people as they start RCMP Cadet Training to learn what factors affect “risk” and “resilience” (how well someone adapts under stress). It may help improve support for cadets during training.
Regina, SaskatchewanAges 19–57 - NCT06417437RecruitingPhase 4
Brain-computer interface test for depression
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
Shanghai, Shanghai MunicipalityAges 12 years+ - NCT06860165Recruiting
Mood tracking app study for adults with depression
This study tests a smartphone app (EmoDTx) that monitors mood in people with unipolar depression. It aims to see if the app can provide helpful digital measurements of your mood.
Changé, FranceAges 18 years+ - NCT07749521Recruiting
Treating depressed parents of children with behavioural problems
This study tests a virtual group treatment to help parents with mild to moderate depression improve their own wellbeing and better support their child's emotional and behavioural health. If you are a parent with depression and have a child aged 6-11 who is struggling emotionally or behaviourally, this trial may be for you.
Toronto, OntarioAges 18 years+
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Common questions
- Are there clinical trials for depressive disorder?
- Yes. Clin2 currently lists 689 recruiting depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.