Clinical trials
Depressive Disorder clinical trials
Below are recruiting depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT07479758Recruiting
Brain scans and vision tests for severe mental illness
This study uses advanced MRI scans and visual perception tests to learn more about severe mental disorders like depression, schizophrenia, and bipolar disorder. It aims to improve diagnosis and treatment outcomes.
Hangzhou, ZhejiangAges 18–45 - NCT06706232RecruitingPhase 2
Psilocybin for Depression and Suicidal Thoughts in Bipolar II
This trial tests if two doses of psilocybin, given under medical supervision, are safe and acceptable for people with Bipolar II disorder who have mild to moderate depression and certain suicidal thoughts. The goal is to see if it may help improve mood and reduce suicidal thinking.
Houston, TexasAges 25–70 - NCT06630065Recruiting
Ketamine study for depression using brain scans
This trial uses brain scans to understand how ketamine affects negative emotions in people with depression. It may help explain why ketamine works and who benefits most.
Paris, ParisAges 18 years+ - NCT07579078Enrolling by invitation
Vitamin D and Brain Activity in Women With Depression
This study tests whether vitamin D supplements can improve brain wave patterns in women diagnosed with depression who have low vitamin D levels. Researchers will measure brain activity using EEG (a non-invasive test that records electrical signals from the brain) before and after vitamin D treatment.
DhakaAges 20–40 - NCT06923995Recruiting
AI-based depression and anxiety assessment study
This study tests an AI tool that analyzes video and audio recordings to measure depression and anxiety. It is for people starting a new treatment for depression or anxiety and aims to see if the AI can accurately track their progress.
Houston, TexasAges 18–65 - NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65 - NCT07364799Recruiting
Sound therapy for stress in detained teens
This trial tests a multi-sensory therapy called SoundHeal for teens in juvenile detention. It uses sound and vibration to help with stress, anxiety, depression, or substance use.
San Luis Obispo, CaliforniaAges 12–18 - NCT07604753Recruiting
Comparing two mental health screening questionnaires
This study compares two different questionnaires that doctors use to diagnose mental health conditions. Researchers want to check if a newer, shorter questionnaire works just as well as the longer standard one.
Hong KongAges 18 years+ - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT07363980Enrolling by invitation
Heart CT Study for Rheumatoid Arthritis Patients
This study uses a special heart CT scan to look for early signs of heart disease in people with rheumatoid arthritis. It may help find problems before symptoms start.
AarhusAges 50–75 - NCT07088380RecruitingPhase 3
Ketamine combined with ECT for hard-to-treat depression
This trial tests whether adding ketamine to electroconvulsive therapy (ECT) works better than ECT alone for people with depression that hasn't improved with at least two different antidepressants. It may offer a new option for those who have not found relief from standard treatments.
MilanAges 18–70 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT07105111RecruitingPhase 4
Valbenazine for tardive dyskinesia after other treatment
This study tests if valbenazine helps adults with tardive dyskinesia whose symptoms continue even after taking or stopping another similar medication. Tardive dyskinesia involves uncontrollable movements from long-term use of certain mental health drugs.
Bryant, ArkansasAges 18 years+ - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT03953014Recruiting
Genetic study of antidepressant side effects in young people
This trial studies whether genes (using a saliva sample) can help explain why some young people feel more “disinhibited” after taking antidepressants like SSRIs. If you’ve had depression, anxiety, or OCD and have used an SSRI, your information and genetics may help improve how antidepressants are chosen and monitored.
Calgary, AlbertaAges 6–17 - NCT00018057RecruitingPhase 2
Brain study of pediatric anxiety disorders
This study looks at how the brain works in children and adults with anxiety disorders. It uses brain scans (fMRI) and other safe tests to understand anxiety better.
Bethesda, MarylandAges 8–65 - NCT07259109Enrolling by invitation
Understanding mental health in teens
This study looks at how mental health conditions affect teenagers aged 12 to 20. It may help doctors better understand and support teens with these challenges.
Messina, ItalyAges 12–20 - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT07657234RecruitingPhase 1/Phase 2
Brain stimulation for depression in older adults
This study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help treat depression in people aged 60 and older. tDCS uses a mild electrical current to gently stimulate the brain and may improve mood when added to your current depression treatment.
Dallas, TexasAges 60 years+ - NCT07389473Recruiting
Studying eye movements in long-term psychiatric medication use (Gaize device)
This trial uses a special device (Gaize) to track how your eyes move while you take psychiatric medication. It aims to see how long-term medication affects eye patterns, which could help doctors better understand treatment responses.
Philadelphia, PennsylvaniaAges 18–65 - NCT07623135RecruitingPhase 3
Lumateperone for Hard-to-Treat Depression in Older Adults
This study tests lumateperone, a new medication added to your current antidepressant, to help treat depression that hasn't improved with other treatments. It's designed for people age 60 and older who have tried at least two antidepressants without success.
Tucson, ArizonaAges 60 years+ - NCT06738953Recruiting
Preventing mental disorders with a self-efficacy course
This trial tests if a course designed to boost your belief in your own abilities can help prevent anxiety, mood, or substance use disorders. It is for young adults who currently feel less confident in handling challenges.
Potsdam, BrandenburgAges 18–30 - NCT07117058Recruiting
Anxiety and depression screening for young cancer survivors
This study tests a quick tool to identify anxiety or depression in children, teens, and young adults who have finished intensive cancer treatment and are now in remission. It aims to help doctors provide better mental health support.
AngersAges 7–25
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Common questions
- Are there clinical trials for depressive disorder?
- Yes. Clin2 currently lists 669 recruiting depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.