Clinical trials · North Carolina
Diabetes clinical trials in North Carolina
We’re tracking 93 recruiting diabetes studies with a site in North Carolina — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT06783309RecruitingPhase 1/Phase 2
Testing CNP-103 for newly diagnosed type 1 diabetes
This trial tests a new study drug called CNP-103 for people ages 12-35 who were recently diagnosed (within 6 months) with stage 3 type 1 diabetes. The goal is to see if the drug can help preserve the body's ability to make some insulin, potentially slowing the need for more insulin shots.
Greenville, North CarolinaAges 12–35 - NCT07463209Recruiting
Learning to use continuous glucose monitoring in diabetes education
This study helps older adults with diabetes learn how to use a continuous glucose monitor (CGM), a small device that tracks blood sugar levels in real time. You'll get education and support to manage your diabetes better, and you may have a care partner join you.
Chapel Hill, North CarolinaAges 65 years+ - NCT06405373Recruiting
Coping skills program for type 1 diabetes distress
This study tests a program to help adults with type 1 diabetes who feel stressed or overwhelmed by their condition. You'll join virtual group sessions to learn coping skills and track how your distress changes over time.
Chapel Hill, North CarolinaAges 30 years+ - NCT07599982Recruiting
Safety test of MODI insulin adjustment system for adults
This trial tests MODI, a smartphone app that helps automatically adjust your insulin doses based on blood sugar readings from a continuous glucose monitor. The study checks if this system is safe and helps people with type 1 or type 2 diabetes manage their blood sugar better.
Morehead City, North CarolinaAges 18–80 - NCT07197775Enrolling by invitation
Endogenex PULSE Registry: Tracking long-term outcomes
This registry collects information from people with type 2 diabetes who have already been treated with the Endogenex System. It helps researchers learn how the treatment works over time.
Raleigh, North CarolinaAges 18 years+ - NCT07197788Enrolling by invitation
Continued access to the Endogenex device study for type 2 diabetes
This trial offers continued access to the Endogenex system for people who were in the sham (placebo) group of the ReCET study and have completed their 12-month visit. It tests a device that treats the duodenum to improve blood sugar control.
Raleigh, North CarolinaAges 22 years+ - NCT05540704Recruiting
Therapy support for eating problems in type 1 diabetes
This study compares three groups: Acceptance and Commitment Therapy, standard supportive diabetes counseling, or a waitlist. It aims to reduce binge eating and harmful weight-control behaviors, including insulin withholding, in people with type 1 diabetes.
Durham, North CarolinaAges 16–50 - NCT07797335RecruitingPhase 3
Zenagamtide for diabetes and weight loss
This study compares a new once-weekly injection to lower blood sugar levels against a standard daily injection in people with type 2 diabetes who are at high risk for heart problems. It aims to find out if the new medicine is more effective in managing blood sugar and body weight.
Morehead City, North CarolinaAges 45 years+ - NCT07662213RecruitingPhase 3
Elecoglipron vs semaglutide for type 2 diabetes
This study tests an experimental diabetes pill (elecoglipron) to see if it works as well as a current medicine, semaglutide, for people with type 2 diabetes who also have heart risk factors. It aims to help better control blood sugar and weight.
Morehead City, North CarolinaAges 18 years+ - NCT07662135RecruitingPhase 3
A study of elecoglipron for type 2 diabetes with kidney problems
This trial tests a new medicine called elecoglipron to see if it helps control blood sugar in people with type 2 diabetes who also have reduced kidney function. You would continue taking your current SGLT2i medication (like dapagliflozin).
Kinston, North CarolinaAges 18 years+ - NCT07509671Recruiting
Can a diet help painful diabetic nerve pain?
This study tests whether a special diet can help reduce pain caused by nerve damage from Type 2 diabetes or prediabetes. You may qualify if you have painful diabetic neuropathy and are looking for a non-medication approach.
Hendersonville, North CarolinaAges 18 years+ - NCT07054125Recruiting
CGM, education, and peer support for type 2 diabetes
This trial tests if using a continuous glucose monitor (a small sensor that tracks your blood sugar), combined with diabetes education and support from others with diabetes, can help people with type 2 diabetes better control their blood sugar. You may qualify if your blood sugar is not well controlled (A1c above 8%).
Asheville, North CarolinaAges 18 years+ - NCT05544266Recruiting
Study rare diabetes patterns to better guide diagnosis
This study looks at people who may have a “non-typical” form of diabetes, including rare genetic causes or unusual symptoms. It may help your care team understand what type of diabetes you have and whether specific genetic testing could explain it.
Chapel Hill, North CarolinaAges Any age - NCT02986984Recruiting
Kidney biopsy study for people with diabetic kidney disease
This study aims to learn more about diabetic nephropathy (kidney problems caused by diabetes) using planned kidney tissue samples. You may benefit by helping researchers understand the disease better, and you may be eligible if you already have a medically needed kidney biopsy scheduled.
Chapel Hill, North CarolinaAges 18–100 - NCT07867080RecruitingPhase 3
Gene therapy injection for diabetic macular edema
This trial tests a one-time gene therapy injection into the eye for adults with diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. The goal is to reduce the need for frequent eye injections and help maintain vision over time.
Asheville, North CarolinaAges 18 years+ - NCT07817251RecruitingPhase 3
Switching From Semaglutide to Cagrisema in Type 2 Diabetes
This study looks at how people with type 2 diabetes tolerate switching from a weekly semaglutide injection (like Ozempic or Wegovy) to a new experimental medicine called Cagrisema. The goal is to see if the switch is safe and effective.
Greensboro, North CarolinaAges 18 years+ - NCT07784270RecruitingPhase 3
Weight loss injection for adults with type 2 diabetes and overweight
This study tests a new injected medicine that may help people with type 2 diabetes and overweight or obesity lose weight. The trial will see how well it works and if it is safe compared to a placebo.
Greensboro, North CarolinaAges 18 years+ - NCT07776509RecruitingPhase 3
Adding a new drug to current weight-loss therapy for adults with obesity or overweight
This study tests a new medication (AZD6234) added to your current weight-management medication (an incretin-based drug) to see if it helps with weight loss. You may be eligible if you are overweight or obese with related health issues or type 2 diabetes.
Statesville, North CarolinaAges 18 years+ - NCT07754461RecruitingPhase 3
Survodutide for blood sugar control in type 2 diabetes
This study tests an investigational drug called survodutide to see if it helps people with type 2 diabetes manage their blood sugar levels. Participants will receive either survodutide or a placebo, and the study will compare changes in HbA1c (a measure of blood sugar control).
Fayetteville, North CarolinaAges 18 years+ - NCT07743450RecruitingPhase 3
Daily oral medication for weight loss in adults with obesity and type 2 diabetes
This study tests a once-a-day pill for adults who are overweight or have obesity and also have type 2 diabetes. The goal is to see if the medication helps with weight loss and improves blood sugar control.
Charlotte, North CarolinaAges 18 years+ - NCT07705607RecruitingPhase 3
Comparing MK-8748 to standard treatment for diabetic eye swelling
This trial tests a new medicine (MK-8748) against an existing treatment (aflibercept) for people with diabetic macular edema, which causes vision loss due to swelling in the back of the eye. The goal is to see which works better to improve or protect vision.
Winston-Salem, North CarolinaAges 18 years+ - NCT07705555RecruitingPhase 3
Comparing a new eye injection to standard treatment for diabetic eye swelling
This trial tests if a new medicine (MK-8748) works as well as or better than the usual treatment (aflibercept) for people with diabetic macular edema, a condition that causes vision loss from diabetes-related swelling in the back of the eye.
Wake Forest, North CarolinaAges 18 years+ - NCT07664553RecruitingPhase 3
Testing a new diabetes tablet for people on insulin
This trial tests a new once-daily tablet (elecoglipron) against a placebo to see if it can help improve blood sugar control in adults with type 2 diabetes who are already on insulin. It may offer an additional treatment option to help manage your diabetes.
Cary, North CarolinaAges 18 years+ - NCT07668388RecruitingPhase 2
Testing different doses of UBT251 for type 2 diabetes
This trial tests a new medicine, UBT251, to see how well it lowers blood sugar in people with type 2 diabetes. It compares different doses to find the best one for you.
Greensboro, North CarolinaAges 18–75
Diabetes trials by city in North Carolina
Where these studies are running in North Carolina
Institutions with a site for the recruiting diabetes studies listed above.
- Research Site · 5 studies
- PharmQuest Life Sciences LLC · 3 studies
- University of North Carolina at Chapel Hill · 3 studies
- Care Access · 2 studies
- Duke University Medical Center · 2 studies
- Accellacare
- Accellacare Wilmington
- AdventHealth Hendersonville
What taking part in a diabetes study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Diabetes trials in other states
Common questions
- Are there diabetes clinical trials in North Carolina?
- Yes. We're currently tracking 93 recruiting diabetes studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a diabetes study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a diabetes trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New diabetes studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.