Clinical trials · California
Down Syndrome clinical trials in California
We’re tracking 275 recruiting down syndrome studies with a site in California — including Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT06669949Recruiting
Studying the natural history of SPLIS disease
This study collects health information from people with SPLIS to better understand the condition over time. It may include your siblings if they also have SPLIS, and data from patients who have passed away.
San Francisco, CaliforniaAges Any age - NCT06690801Recruiting
Nitric oxide breathing gas for children with lung failure
This trial tests whether adding a breathing gas called nitric oxide to standard care helps children with severe lung failure (ARDS) recover faster. It is for children on a breathing machine who still have low oxygen levels.
Los Angeles, CaliforniaAges birth–21 years - NCT07545759RecruitingPhase 2
Testing brenipatide for IBS with diarrhea symptoms
This study tests whether a new medication called brenipatide can help people with IBS-diarrhea (IBS-D) reduce belly pain and loose stools. IBS-D is a condition where the intestines move too quickly, causing frequent diarrhea and discomfort.
Anaheim, CaliforniaAges 18–75 - NCT07545772RecruitingPhase 2
Testing Brenipatide for Constipation-Focused IBS
This trial tests a new medicine called brenipatide to see if it can help people with IBS-C (irritable bowel syndrome with constipation). The study focuses on whether the drug reduces belly pain and improves bowel movements in people whose main symptom is hard or infrequent stools.
Anaheim, CaliforniaAges 18–75 - NCT07216443RecruitingPhase 2
Study of orca-t for leukemia or MDS with reduced intensity chemo
This trial tests a new cell therapy, orca-t, given after a lower-intensity chemo and radiation regimen for people with acute myeloid leukemia, mixed phenotype leukemia, or myelodysplastic syndrome. It aims to help patients who cannot tolerate full-intensity transplant conditioning.
Los Angeles, CaliforniaAges 18 years+ - NCT06716411Recruiting
Acupuncture for Gulf War Illness relief
This study tests whether acupuncture can help relieve Gulf War Illness symptoms like fatigue, mood or thinking problems, and muscle or joint pain. You may be able to join if you were deployed to the Gulf region and have had these symptoms for more than 6 months.
Los Angeles, CaliforniaAges 18 years+ - NCT06726785Recruiting
Gene changes in nasal cells of RLS patients on long-term dopamine agonist
This study looks at changes in a gene (DRD2) in nasal cells of people with Restless Legs Syndrome who are taking a dopamine agonist medication for a long time. It aims to understand how this gene might be involved in RLS.
San Francisco, CaliforniaAges 18–60 - NCT06747949RecruitingPhase 3
Long term extension study of dazodalibep for Sjogren's syndrome
This study gives continued access to the study drug dazodalibep for people with Sjogren's syndrome who completed a prior phase 3 study. The goal is to see how safe and effective the medication is over a longer period.
La Jolla, CaliforniaAges 18 years+ - NCT06819670RecruitingPhase 2
Preventing infantile spasms from coming back
This trial tests whether a longer course of steroids can keep infantile spasms from returning in babies who have already responded to standard treatment. It may help reduce the chance of relapse.
Los Angeles, CaliforniaAges 2 months–1.5 years - NCT06840496RecruitingPhase 3
Study of oral NA-921 vs placebo for girls and women with Rett syndrome
This trial tests an oral medication called NA-921 in females with Rett syndrome to see if it works better than a placebo. It may be an option for those who have a confirmed MECP2 gene mutation and stable seizure patterns.
Los Angeles, CaliforniaAges 5–20 - NCT06847867RecruitingPhase 2
Testing momelotinib for low-risk myelodysplastic syndrome
This study tests a new drug, momelotinib, for people with a low-risk form of myelodysplastic syndrome (MDS) who need red blood cell transfusions and have already tried one other treatment (like ESAs or luspatercept). The goal is to see if momelotinib can help reduce transfusion needs.
Duarte, CaliforniaAges 18 years+ - NCT06851338Recruiting
Inspire therapy study for teens with Down syndrome and sleep apnea
This study tests a device called Inspire that stimulates the airway during sleep to treat obstructive sleep apnea in teenagers with Down syndrome who cannot use a CPAP machine or had a tonsillectomy that did not work well.
Orange, CaliforniaAges 13–18 - NCT06874855RecruitingPhase 4
Study of sleep medication for delayed sleep phase syndrome
This trial tests whether a sleep medication called lemborexant can help people with delayed sleep phase syndrome fall asleep earlier. It may improve sleep timing and reduce the impact on daily life.
San Francisco, CaliforniaAges 18 years+ - NCT07020819RecruitingPhase 3
Study of tanruprubart for people with Guillain-Barré syndrome
This trial tests a new medicine, tanruprubart (also called ANX005), for people with Guillain-Barré syndrome. It aims to see if the drug can help improve recovery when given soon after symptoms start.
Orange, CaliforniaAges 12–85 - NCT07157254RecruitingPhase 2
Study of GTX-102 for People with Angelman Syndrome
This study tests an experimental drug called GTX-102 for people with Angelman syndrome. It aims to see if the drug is safe and can help with symptoms. The trial includes different age groups and genetic types of Angelman syndrome.
Los Angeles, CaliforniaAges 1–64 - NCT07209462RecruitingPhase 2
MRM-3379 for Fragile X Syndrome in males
This trial tests an investigational medicine called MRM-3379 in males with Fragile X syndrome. It looks at how the medicine affects thinking and behavior over time.
Irvine, CaliforniaAges 13–45 - NCT07219602RecruitingPhase 3
Study of obicetrapib and ezetimibe for diabetes and metabolic syndrome
This trial tests a combination medication (obicetrapib plus ezetimibe) taken daily to lower cholesterol and triglycerides in people with type 2 diabetes or metabolic syndrome who are already on standard cholesterol treatment. It may help reduce heart risks.
La Jolla, CaliforniaAges 18 years+ - NCT05066217RecruitingPhase 3
Study tests clemizole for Lennox-Gastaut seizures
This Phase 3 trial studies whether clemizole helps reduce seizures in people with Lennox-Gastaut syndrome (LGS) and checks safety. If you have LGS and meet the seizure and heart-safety requirements, this could be an option to explore.
Orange, CaliforniaAges 2–55 - NCT07280468RecruitingPhase 4
Personalized sleep apnea treatment for Down syndrome
This study tests if a treatment chosen based on your specific type of sleep apnea works better for people with Down syndrome. It looks for participants who have sleep apnea but are not already using a CPAP machine regularly.
San Diego, CaliforniaAges 6 years+ - NCT01403402Recruiting
Study of congenital muscle disease patients and their families
This trial collects health information from patients with certain inherited (genetic) muscle diseases and from their families. It may help researchers better understand the disease and improve care by learning what symptoms and treatments patients experience over time.
Lakewood, CaliforniaAges Any age - NCT02502162Recruiting
Low-dose naltrexone for complex regional pain syndrome
This trial tests whether low-dose naltrexone can reduce symptoms of complex regional pain syndrome (CRPS), a long-lasting pain condition in an arm or leg. It may help by targeting pain signaling, but you must meet specific CRPS diagnosis and medication rules to join.
Palo Alto, CaliforniaAges 18–70 - NCT03137472Recruiting
Brain stimulation to treat complex regional pain syndrome
This trial studies whether noninvasive brain stimulation (TMS) can reduce pain in people with complex regional pain syndrome (CRPS). It may help if your CRPS has lasted at least a few months and you can safely undergo the stimulation and study tasks.
Redwood City, CaliforniaAges 18–70 - NCT07675109Recruiting
Extended therapy for restless legs syndrome
This study tests a device that delivers nerve stimulation to help with restless legs syndrome (RLS). It aims to see if using the device for a longer period each night can reduce RLS symptoms and improve sleep.
Pleasanton, CaliforniaAges 21 years+ - NCT00616317Recruiting
Study for children with antiphospholipid syndrome and blood clots
This study is for children who have antiphospholipid syndrome (APS) and a history of blood vessel clots. Researchers want to learn more about APS in pediatric patients who have specific blood test signs and clot history.
Sacramento, CaliforniaAges 1 minute–18 years
Down Syndrome trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting down syndrome studies listed above.
- Children's Hospital of Orange County · 2 studies
- Om Research LLC · 2 studies
- Smart Cures Clinical Research · 2 studies
- Stanford University · 2 studies
- United Medical Doctors · 2 studies
- University of California, Davis Medical Center · 2 studies
- University of California, Irvine Medical Center / UC Irvine Health · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
What taking part in a down syndrome study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Down Syndrome trials in other states
Common questions
- Are there down syndrome clinical trials in California?
- Yes. We're currently tracking 275 recruiting down syndrome studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a down syndrome study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New down syndrome studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.