Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,187 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT02673996Recruiting
Study of POTS body chemical signals and blood pressure control
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
Calgary, AlbertaAges 18–60 - NCT03215836Recruiting
Study obesity and metabolism in adults with asthma
This study looks at how weight and blood-sugar/fat changes in the body may affect the airways in people with asthma. You may be asked to complete breathing tests and possibly an airway procedure (bronchoscopy) to help researchers compare groups.
Aurora, ColoradoAges 18–65 - NCT03049462RecruitingPhase 1
Study how a beta-3 drug changes body fat in healthy adults
This Phase 1 study tests how chronic treatment with a beta-3–type medicine affects brown fat (a special kind of body fat) in the body. It mainly looks at safety and how the body responds over time, which could help future treatments for weight and metabolic health.
Bethesda, MarylandAges 18–40 - NCT02964637Recruiting
Tests to help diagnose frontotemporal dementia
This study looks at testing (including brain scans) to figure out what type of frontotemporal dementia or related language/speech condition a person has. It may help by making diagnoses more accurate, which can guide better care.
Toronto, OntarioAges 18–90 - NCT03314974RecruitingPhase 2
Stem cell transplant study for blood cancers
This Phase 2 study tests a strong (myeloablative) stem cell transplant using donor stem cells (allogeneic transplant) for certain blood and bone marrow cancers. The goal is to see how well this approach works and whether it can improve outcomes for people who need transplant-level treatment.
Minneapolis, MinnesotaAges Up to 60 years - NCT03087253Recruiting
Study of what causes and affects lipodystrophy
This study observes people with lipodystrophy to better understand how the condition develops and affects the body over time. It may help researchers learn who is most affected and guide future treatments.
Bethesda, MarylandAges Any age - NCT03368092RecruitingPhase 3
Inhaled medication to prevent lung failure after severe trauma
This trial tests whether inhaled dornase alfa can reduce the risk of respiratory (lung) failure in adults with severe trauma who are on a breathing machine in the ICU. If it works, it may help patients spend less time with dangerous breathing complications.
StrasbourgAges 18 years+ - NCT02929732Recruiting
Study muscle nerve activity in restless legs
This study looks at how active the nerves are in people with Willis-Ekbom disease (restless legs syndrome) and compares them with people without it. It may help researchers understand what drives symptoms and how the condition works in the body.
MontpellierAges 18–74 - NCT03218332Recruiting
Study of concussion symptoms in professional athletes
This study looks at persistent symptoms after concussions in professional athletes and compares different concussion histories. It aims to understand what contributes to ongoing problems and whether certain patterns can be identified to guide better care.
Toronto, OntarioAges 25–85 - NCT03222375Recruiting
Home treatment for autism using special sound and imaging devices
This trial studies a home-based treatment for autism (or related conditions) using specially designed sound, image, and electromagnetic devices. It aims to see whether this personalized “treatment code” and device approach can improve autism-related skills and behaviors.
Louisville, KentuckyAges 1 month–21 years - NCT03281798Recruiting
Fetal bladder procedure for severe blockage in a baby boy
This trial studies a fetal cystoscopy procedure to treat severe urinary tract blockage in a baby boy during pregnancy. It aims to see whether the procedure helps improve outcomes, but it requires specific pregnancy conditions and testing beforehand.
Miami, FloridaAges 18 years+ - NCT03300492RecruitingPhase 1/Phase 2
Natural killer cell treatment after a half-matched stem cell transplant
This early trial studies adding special immune cells called “natural killer cells” after a half-matched stem cell transplant for AML or MDS. The goal is to see if this approach improves outcomes and safety when there is no fully matched donor available.
BaselAges 18 years+ - NCT07010250Recruiting
Kidney Energy Use and Scarring in ANCA Vasculitis
This study looks at how kidney cells use energy and how that leads to scarring in people with ANCA vasculitis. It compares findings with people who have other kidney diseases to better understand and possibly treat kidney damage.
ParisAges 18–90 - NCT07262541Recruiting
Measuring airway opening pressure in children on ventilators
This study tests a simple way to measure the pressure needed to open the airways in children on a breathing machine. It may help doctors provide better breathing support for your child in the intensive care unit.
ParisAges Up to 17 years - NCT06813339RecruitingEarly Phase 1
Testing a new drug in healthy people and those with heart condition
This trial tests a new medicine called UDP-003 in two groups: healthy volunteers and people who had a heart event (acute coronary syndrome) at least a year ago. The goal is to see if the drug is safe and how the body handles it, which could lead to better treatments for heart disease.
Adelaide, South AustraliaAges 18–79 - NCT07674953Recruiting
CPAP and oxygen delivery in preterm infants
This study looks at how different levels of CPAP (a breathing machine that helps keep the lungs open) affect oxygen delivery and lung expansion in preterm babies. It may help doctors understand the best settings for infants who need breathing support.
Little Rock, ArkansasAges Any age - NCT06512883RecruitingPhase 3
Testing benralizumab in children with eosinophil diseases
This trial tests a medicine called benralizumab for children with specific eosinophil-driven diseases (EGPA or HES). It aims to see if the drug can help control these conditions.
Aurora, ColoradoAges 6–17 - NCT07675655Recruiting
Mulligan vs. PNF exercises for shoulder pain
This trial compares two hands-on therapy techniques for people with shoulder impingement (pain when lifting the arm). It tests if one method works better for reducing pain and improving movement.
Sohag, TahtaAges 20–40 - NCT04369599Enrolling by invitation
Test chest vibration during ventilation for severe lung failure
This study looks at whether a special chest “vest” and related lung measurements can improve breathing in people with sudden severe lung failure who need a breathing machine. You may be eligible if you have ARDS and can safely use the vest during mechanical ventilation.
Atlanta, GeorgiaAges 18 years+ - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT02646839Enrolling by invitationPhase 2
Testing a gene-matched transplant approach for childhood leukemia
This trial studies a specific type of partially matched (haploidentical) stem cell transplant in children with ALL, AML, or MDS. It looks at whether using certain immune system gene patterns (KIR) and measuring leftover disease after treatment can improve outcomes and cost-effectiveness.
Los Angeles, CaliforniaAges Up to 21 years - NCT01803906Enrolling by invitation
Tissue sample study for suspected mitochondrial disorders
This study collects tissue samples to help researchers learn more about mitochondrial disorders—conditions related to how the body makes energy. It may help by improving genetic understanding for families who suspect an inherited cause.
New York, New YorkAges Any age - NCT00807482Recruiting
Study of lung disease causes in primary ciliary dyskinesia
This study looks at how primary ciliary dyskinesia (PCD—a lifelong problem with tiny lung “sweepers”) affects the lungs. You may be able to join if you strongly seem to have PCD based on symptoms, or if you’re a healthy person with a close family member who has confirmed PCD.
Chapel Hill, North CarolinaAges Any age - NCT01186913Enrolling by invitation
Natural history study for severe combined immune deficiency (SCID)
This study follows children and adults with SCID and related immune disorders to understand how the illness behaves over time. It also helps researchers learn which testing results and genetic types of SCID match different treatment plans.
Birmingham, AlabamaAges Any age
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,187 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.