Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07059715Recruiting
Studying blood flow during heart surgery for vasoplegia risk
This study looks at blood flow in small and large vessels during heart surgery to understand and predict vasoplegic syndrome, a dangerous drop in blood pressure. It may help find patients at risk and improve their care.
ParisAges 18 years+ - NCT07714031Recruiting
Wrist Release Therapy for Overuse Syndrome
This study tests a special hands-on therapy technique for people with wrist pain from overuse, like computer workers. It may help improve movement and reduce pain without surgery.
Faisalabad, Punjab ProvinceAges 20–50 - NCT05710627Recruiting
Testing TENEX for hip pain from greater trochanteric pain syndrome
This trial studies whether TENEX (a minimally invasive procedure) can reduce hip pain caused by greater trochanteric pain syndrome (GTPS). It is for people who have tried non-surgical treatments for at least 6 months without enough relief, and who have confirmed GTPS on imaging (MRI or CT).
The Bronx, New YorkAges 30–90 - NCT07069010Recruiting
Palliative care education for ICU staff
This trial studies whether a tele-palliative care education program can reduce burnout in ICU clinicians. It involves completing surveys before and during the program.
AthensAges Any age - NCT06694363Recruiting
New test to guide treatment for APDS immune disorder
This study uses a new blood test to find and monitor people with APDS, a rare immune disease, who may be helped by the drug leniolisib. It aims to improve how doctors screen and track treatment response.
BordeauxAges 12 years+ - NCT07126028Enrolling by invitation
Quality of life in kids after MIS-C
This study looks at how children feel and live their daily lives after recovering from MIS-C (a severe inflammatory condition linked to COVID-19). It compares them to healthy children of the same age and gender to see if there are any lasting effects.
Rijeka, Primorje-Gorski Kotar CountyAges 1 month–18 years - NCT07586553Recruiting
Walking Test Study for Older Adults With Memory Concerns
This study tests a special walking pattern called the figure-of-8 walk in older adults who are noticing memory problems but don't have dementia yet. Researchers want to understand how walking ability connects to thinking and memory changes.
Balıkesir, BigadiçAges 65 years+ - NCT07090889RecruitingPhase 1
Study of KM-023 for healthy volunteers and Olmsted syndrome patients
This trial tests a new medication, KM-023, first in healthy volunteers to check safety, and then in people with Olmsted syndrome (a rare skin condition causing thick, painful palms and soles). It aims to see if the drug is safe and helpful for those affected.
Chicago, IllinoisAges 18–55 - NCT07588061Recruiting
Neck Pain Treatment: Mobilization and Posture Exercises
This study tests whether combining two types of physical therapy—manual joint mobilization and specific posture-strengthening exercises—can reduce neck and upper back pain and improve how you hold your body. You may qualify if you have persistent neck pain linked to poor posture.
Peshawar, KPKAges 18–45 - NCT07150026RecruitingPhase 1
Testing vorinostat for Pitt Hopkins syndrome
This trial tests whether vorinostat, a medication that may affect gene activity, is safe and helpful for children and young adults with Pitt Hopkins syndrome. Participants take the drug by mouth or feeding tube.
MedellínAges 3–21 - NCT07526051Recruiting
Stretching techniques for lower back pain and muscle tightness
This study compares two stretching methods to help relieve lower back pain caused by muscle imbalances. You'll be tested to confirm the pattern of muscle tightness, then receive one of two types of stretching therapy to see which works better for your pain.
Islamabad, Punjab ProvinceAges 25–50 - NCT07696533Recruiting
Comparing two imaging tests for chronic coronary syndrome
This trial sees if a carotid ultrasound is as good as a CT calcium score to detect heart disease in people with chest pain. It may help avoid more expensive or less available scans.
HarrowAges 18 years+ - NCT07026890Recruiting
Virtual reality for elderly with psychomotor disadaptation
This trial tests if using virtual reality can help older adults who have trouble moving and adapting to their surroundings (psychomotor disadaptation syndrome). It aims to improve their care while in a hospital geriatric unit.
DijonAges 65 years+ - NCT07690527Enrolling by invitationPhase 1
Long-term follow-up for RB001 gene therapy in children with Phelan-McDermid syndrome
This study follows children who completed the RB001 gene therapy trial for Phelan-McDermid syndrome (caused by changes in the SHANK3 gene) to monitor their health and progress over a longer period of time.
Beijing, ChinaAges Any age - NCT06641414RecruitingPhase 3
Lisaftoclax and azacytidine for higher-risk MDS
This trial tests a new drug, lisaftoclax, combined with azacytidine for people newly diagnosed with higher-risk myelodysplastic syndrome (MDS). The goal is to see if this combination can help control the disease better.
Houston, TexasAges 18 years+ - NCT07465614Recruiting
Nerve stimulation study for children with cyclic vomiting syndrome
This study tests whether a gentle nerve stimulation device placed on the ear can reduce vomiting episodes in children with cyclic vomiting syndrome (CVS). It aims to find a safe, non-drug option for managing symptoms.
Milwaukee, WisconsinAges 5–18 - NCT06896708Recruiting
Intensive cholesterol treatment for heart plaque in younger adults
This trial tests whether higher doses of cholesterol-lowering medication (statins) can slow down plaque buildup in the heart arteries of younger and middle-aged adults with stable chest pain. It may help prevent heart attacks and the need for procedures like stents.
Chongqing, Chongqing MunicipalityAges 18–60 - NCT06879938Recruiting
Hyaluronic Acid and Oxygen Therapy for Menopause Symptoms
This trial tests a combination of a vaginal gel (hyaluronic acid) and a special oxygen device for women experiencing vaginal dryness and discomfort due to menopause, including those with a history of breast cancer. It aims to see if this treatment can improve symptoms better than standard care.
Pavia, PaviaAges 18 years+ - NCT07380594Recruiting
Study of psychiatric symptoms in White-Sutton syndrome
This study looks at mental health symptoms in people with White-Sutton syndrome, a rare genetic condition. By answering questions, you can help doctors better understand what challenges people face and how to support them.
DijonAges 6 years+ - NCT06613607Recruiting
Core exercises for lower back pain and balance
This study tests whether core-strengthening exercises can improve pelvic alignment, balance, and agility for people with lower cross syndrome—a pattern of muscle tightness and weakness that often causes low back pain. If you have mild to moderate lower back pain that gets better when you move, you may be a candidate.
Rawalpindi, Punjab ProvinceAges 19–35 - NCT07350707RecruitingPhase 1/Phase 2
PET scan for Cushing's syndrome using two tracers
This trial tests if a special PET scan using two different tracers (68Ga-Pentixafor and 68Ga-DOTATATE) can help diagnose Cushing's syndrome and find its cause. It may help doctors better understand your condition and guide treatment.
Beijing, Beijing MunicipalityAges 10–80 - NCT06546189Recruiting
Probiotics for overactive bladder treatment
This study tests whether a daily probiotic supplement (Lactobacillus) can help reduce overactive bladder symptoms. It compares the supplement to a placebo in a randomized trial.
ViennaAges 18 years+ - NCT07328048Enrolling by invitation
Senobi and aerobic exercise for PCOS
This trial compares two types of exercise—Senobi (a gentle hand-and-breath routine) and aerobic exercise—to see which better helps women with PCOS. It may improve menstrual regularity and help with weight management.
Lahore, Punjab ProvinceAges 18–35 - NCT07327606Recruiting
Heart, kidney, and metabolism health study
This study follows people with different stages of heart-kidney-metabolic syndrome to understand what factors affect their health over time. It aims to find better ways to predict and manage the condition.
Beijing, Beijing MunicipalityAges 18–85
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.