Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04792463Recruiting
BAP1 gene cancer-risk study and family cancer patterns
This study looks at how the BAP1 gene affects cancer risk and what cancers people develop, including within families. You may be able to join if you have a known BAP1-related mutation, a strong family cancer history, or a concerning cancer pattern linked to BAP1.
Columbus, OhioAges Any age - NCT04798651Recruiting
Study immune blood and spinal fluid cells in multiple sclerosis
This study looks at different immune cells in blood and, sometimes, spinal fluid (CSF) to understand what’s driving multiple sclerosis (MS) or early MS-like symptoms. Your participation may help researchers better explain the disease and potentially improve how it’s diagnosed or treated.
BordeauxAges 18 years+ - NCT04802707RecruitingPhase 2
Study drug for mitochondrial depletion disorder due to gene changes
This Phase 2 trial tests a treatment made from deoxynucleosides to help people with mitochondrial depletion disorder caused by certain gene changes. If you match the genetic diagnosis, the study may see whether the treatment improves symptoms or disease markers.
Montreal, QuebecAges 1 month–60 years - NCT04806282Recruiting
Study to track hearing instability and find helpful targets
This study follows adults with hearing instability to better understand what causes it, measure it in new ways, and look for potential treatment targets. If you qualify, you may get hearing and balance-related testing (including scans) over a period of time.
Bethesda, MarylandAges 18–80 - NCT04812314Recruiting
Study how exercise changes body fat and metabolism
This study looks at how starting exercise changes the structure and function of body fat. It may help you understand how exercise affects things like cholesterol and blood sugar, even if you’re not currently exercising regularly.
Ann Arbor, MichiganAges 18–40 - NCT04831346Recruiting
Laser treatment to improve jaw opening in young women
This study tests whether low-level laser therapy can improve how far you can open your jaw and changes in jaw muscle activity in people with one-sided jaw muscle temporomandibular disorder (TMD). It may help reduce jaw movement limits related to that condition.
GizaAges 18–30 - NCT04845217RecruitingPhase 1/Phase 2
Peppermint oil for bladder pain in women
This trial tests whether peppermint oil can reduce symptoms of interstitial cystitis (also called bladder pain syndrome). It’s mainly looking at safety and early signs it may help your bladder discomfort.
Louisville, KentuckyAges 18–65 - NCT04859218Recruiting
Study whether O-type blood affects outcomes in MDS patients
This study looks at whether receiving red blood cell transfusions from O-type donors changes outcomes for people with low-risk myelodysplastic syndrome (MDS). It may help doctors choose which blood types to use to improve how patients feel and function over time.
Hamilton, OntarioAges 18–120 - NCT04873037Recruiting
BTL Emsella chair vs sham for overactive bladder relief
This trial tests whether a specialized chair treatment (BTL Emsella) can reduce bladder urgency and overactive bladder symptoms compared with a sham (placebo) chair session. It may help people who have already tried behavioral steps and/or bladder medications but still have symptoms.
Royal Oak, MichiganAges 18 years+ - NCT04874038RecruitingPhase 3
Lidocaine infusions to prevent long-lasting pain after breast surgery
This Phase 3 study tests whether receiving lidocaine through an IV during breast surgery can lower the chance of ongoing pain afterward. If it works, it may help some people avoid chronic, surgery-related pain in the chest wall, shoulder, or arm.
Calgary, AlbertaAges 18–100 - NCT04881318Recruiting
Compression garments for POTS symptoms at home
This study tests whether wearing waist-high compression garments in everyday life can reduce symptoms for people with POTS. You’ll take part over a 4-day period and compare different days with a washout period in between.
Calgary, AlbertaAges 18–60 - NCT04885179Recruiting
Study of SPLIS genetics and patient experiences
This observational study and patient registry collects information from people diagnosed with SPLIS due to specific changes in the SGPL1 gene, including children and newborns. It helps researchers understand the condition better and may improve future care and research planning.
San Francisco, CaliforniaAges Any age - NCT04888741RecruitingPhase 2
Trial testing reduced immune T cells before stem cell transplant
This Phase 2 trial looks at a transplant approach that reduces harmful immune cells (T cells) before or during an allogeneic stem cell transplant. It may help lower the risk of transplant complications while still letting the donor immune system fight the blood cancer.
Cardiff, WalesAges 16–70 - NCT04898790Recruiting
Testing ways to improve thinking after bone marrow transplant
This study looks at whether a physical activity program and related study measures can improve thinking and memory in older adults around the time of a stem cell transplant. If you qualify and participate, the team will compare outcomes between groups to see what approach works best.
Omaha, NebraskaAges 19 years+ - NCT04902807Recruiting
Tool to help decide diagnosis and treatment in immune disorders
This trial tests a tool (a way of collecting health information) to help doctors make better diagnosis, prognosis, and treatment decisions for children with certain immune problems. It also includes healthy children (like relatives) as comparison groups, to see how well the tool works.
ParisAges 1–18 - NCT04903262Recruiting
Extra CO2 removal to protect lungs in moderate ARDS
This study tests an “extra-CO2 removal” breathing support approach to help protect the lungs in people with moderate ARDS, a serious lung injury. You would be on a ventilator for a short time, and the team would check whether this approach improves breathing outcomes while aiming to be safer for the lungs.
BolognaAges 18–100 - NCT04903782Recruiting
Family whole-genome testing for children with newly diagnosed cancer
This study offers whole-genome testing (a way to read a person’s DNA) to families after a child is newly diagnosed with cancer. It aims to find inherited changes that may explain why cancer happened and guide future care or monitoring.
Newcastle, New South WalesAges Up to 21 years - NCT04909138Recruiting
Intermittent nerve stimulation instead of daily low-frequency therapy
This study tests whether switching from continuous implanted nerve stimulation to an intermittent schedule can keep pain relief for people with chronic back and/or leg pain. You would be compared in a structured study plan to see if the alternate dosing works for you and is safe.
Chicago, IllinoisAges 18–90 - NCT07699224Recruiting
Menstrual cycle symptoms and women's health study
This study looks at the natural menstrual cycle symptoms and overall health in women who are not using hormonal birth control. It aims to understand how cycle-related symptoms affect daily life.
MadridAges 18–45 - NCT07155070RecruitingPhase 4
Can eye drops help LASIK recovery?
This trial tests if Kera Sol Tears eye drops can reduce eye discomfort after LASIK surgery. If you are planning to have LASIK, this study may help you feel better during recovery.
Sioux Falls, South DakotaAges 18 years+ - NCT04771130RecruitingPhase 1/Phase 2
Study of BGB-11417 for blood cancers
This early-phase study tests BGB-11417 in people with certain bone-marrow (blood) cancers such as AML, MDS, or MDS/MPN. The goal is to find out how the medicine works and whether it can control the cancer.
Duarte, CaliforniaAges 18 years+ - NCT06865885RecruitingPhase 4
Lowering cholesterol with inclisiran in people on many medications
This study tests a new injectable medicine called inclisiran for people who are already on many medications and have high cholesterol. It is designed for those who cannot lower their cholesterol enough with statins, especially if they have diabetes or other heart risks.
La Jolla, CaliforniaAges 18–85 - NCT04937699RecruitingPhase 4
Switching anti-platelet tablets after a heart stent
This trial studies whether changing the timing and type of blood-thinner tablets after a heart stent is as safe and effective as continuing the same plan. It may help some people by simplifying treatment while preventing dangerous clotting after a coronary procedure.
Hangzhou, ZhejiangAges 18–80 - NCT04942080Recruiting
Using CALR test results to track certain blood cancers
This study looks at how much of a specific gene change (CALR) you have, and whether it helps doctors diagnose and follow people with certain blood cancers over time. It mainly involves using samples and medical data rather than testing a new drug.
AngersAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.