Clinical trials
Drug Use Disorders clinical trials
Below are recruiting drug use disorders clinical trials, each written for real people, not researchers. We’re tracking 287 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06854757Recruiting
Support after losing a loved one to overdose
This study is for people who lost a loved one to an unintentional drug overdose in the past year. It looks at how families are doing after such a loss and what kind of support might help.
Birmingham, AlabamaAges 18 years+ - NCT02670161Enrolling by invitationPhase 4
Using electronic records to improve care for brain and nerve conditions
This study looks at how doctors use electronic medical records to improve treatment and care for people with certain brain and nervous system conditions. It may help because it tests practice-based approaches across neurology visits.
Evanston, IllinoisAges 18–100 - NCT07119567Recruiting
Cocaine use and withdrawal effects on sleep
This study looks at how cocaine use and stopping cocaine affect sleep. It may help people with cocaine use disorder who are planning to detox in a hospital.
Bron, AURAAges 18 years+ - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT06969170RecruitingPhase 2
Psilocybin oral solution for generalized anxiety disorder trial
This study tests a psilocybin oral solution in adults with generalized anxiety disorder (GAD). It aims to see if the drug is safe, tolerable, and helpful for reducing anxiety symptoms.
Kingston, OntarioAges 18–60 - NCT06794983Recruiting
Support after jail for health and substance use
This study tests a program that helps people leaving jail connect with healthcare and community services. It is for adults with a history of substance use and a chronic health condition who qualify for Wisconsin Medicaid.
Madison, WisconsinAges 18 years+ - NCT06573476Recruiting
Smartphone app and peer coach for opioid treatment
This study tests whether a smartphone app and support from a peer recovery coach can help Black and Latinx individuals with opioid use disorder start buprenorphine treatment. The goal is to reduce overdose deaths and address racial gaps in care.
New York, New YorkAges 18–99 - NCT06532370Recruiting
Reward program for methamphetamine use after trauma in Hawaii
This study tests a program that uses rewards (like gift cards) to encourage people who use methamphetamine and have been hospitalized for a trauma to stop using. The program is designed for people in Hawaii and aims to help them reduce or quit methamphetamine use.
Honolulu, HawaiiAges 18 years+ - NCT05958017Recruiting
ReSET program to help stimulant use in HIV clinics
This study tests a care-support program called ReSET to improve adherence to treatment and reduce stimulant use for people living with HIV who are not currently in drug treatment. You may be offered support through HIV clinic care to help you stay on track, especially if you have access to a smartphone and stable housing.
Miami, FloridaAges 18–90 - NCT06860607RecruitingPhase 1
Environment and Alcohol: A Pilot Study
A pilot study exploring the interaction between environment and alcohol consumption in individuals with alcohol use disorder (AUD), using smartphone-based ecological momentary assessment (EMA).
Baltimore, MarylandAges 21–100 - NCT05684094Recruiting
Study links sleep, stress, and brain reward in risky drinking
This study looks at how sleep timing and stress affect brain responses related to reward and stress in young adults who drink heavily. It may help researchers understand why some people take bigger alcohol risks and how sleep and stress could be part of safer treatment.
Eugene, OregonAges 18–24 - NCT06952491Enrolling by invitation
Study on substance use and well-being
This trial tests a program to help people who use substances like cannabis, tobacco, or prescription drugs for nonmedical reasons. It aims to improve well-being and confidence in managing health.
San Mateo, CaliforniaAges 21 years+ - NCT07046819RecruitingPhase 2
Tirzepatide for liver disease linked to alcohol use
This trial tests if tirzepatide, a medication that helps with weight and blood sugar, can improve liver health in people with alcohol use disorder who also have fatty liver disease. It aims to reduce liver fat and related risks.
Bethesda, MarylandAges 21–100 - NCT06349083RecruitingPhase 2
Psilocybin-assisted treatment for alcohol use disorder
This study tests whether psilocybin, a psychedelic drug, combined with therapy can help people reduce or stop drinking. It aims to understand how psilocybin affects the brain and behavior in people with alcohol use disorder.
New York, New YorkAges 18–65 - NCT07457489Recruiting
Brain stimulation for opioid recovery
This study tests a non-invasive brain stimulation technique called TMS to see if it can reduce opioid cravings and help people who are already taking buprenorphine stay in recovery. TMS uses magnetic pulses to stimulate parts of the brain involved in addiction.
Brentwood, TennesseeAges 18–65 - NCT04793685RecruitingPhase 2
Prazosin for alcohol withdrawal symptoms in alcohol use disorder
This study tests whether prazosin can reduce symptoms that happen when someone stops or cuts back on heavy drinking. It may help people with moderate-to-severe alcohol use disorder who also have alcohol withdrawal symptoms.
New Haven, ConnecticutAges 18–70 - NCT07086014Recruiting
Brain response to methamphetamine cues in men
This study uses brain scans to see how men with methamphetamine use disorder react to images or reminders of the drug. It aims to understand cravings and brain activity, which could help improve treatments.
New York, New YorkAges 18–60 - NCT05703685RecruitingPhase 1
Imaging brain inflammation target in depression with PET
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
Bethesda, MarylandAges 18–70 - NCT04914091Recruiting
Study comfort and medication use after CAR-T therapy
This study looks at quality of life and how medicines are used for people who are getting CAR-T cell therapy for DLBCL. It aims to better understand what helps patients feel and function during follow-up after treatment.
Pierre-BéniteAges 18 years+ - NCT07644052RecruitingPhase 3
A medication to ease cannabis withdrawal symptoms
This study tests whether a medication called PP-01 can help reduce cravings and uncomfortable symptoms when people stop using cannabis. If you're a heavy cannabis user who wants to quit and experiences withdrawal symptoms, this trial may help you manage the difficult transition.
Little Rock, ArkansasAges 18–55 - NCT06989853RecruitingEarly Phase 1
Testing troriluzole for methamphetamine use disorder
This study tests whether a medication called troriluzole can help people who use methamphetamine. If you have methamphetamine use disorder and are not seeking treatment right now, this study may be an option for you.
Lexington, KentuckyAges 18–55 - NCT07091877Recruiting
Cocaine use and brain response study
This study looks at how cravings for cocaine change over time in people who have recently stopped using. Researchers will measure brain activity to understand this process better.
New York, New YorkAges 18–65 - NCT07086794RecruitingEarly Phase 1
Testing if pentoxifylline helps reduce cocaine use
This study tests whether a medication called pentoxifylline can reduce cocaine use in people who smoke or inject cocaine but aren't ready to stop. You'll receive either pentoxifylline or a placebo to see if it helps control cravings or use.
Lexington, KentuckyAges 18–55
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Common questions
- Are there clinical trials for drug use disorders?
- Yes. Clin2 currently lists 287 recruiting drug use disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug use disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug use disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.