Clinical trials
Early-stage Breast Cancer clinical trials
Below are recruiting early-stage breast cancer clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07054190RecruitingPhase 2
Testing Inavolisib in early-stage breast cancer with PIK3CA mutation
This trial is testing a drug called Inavolisib (a type of targeted therapy) given before surgery for people with early-stage, hormone receptor-positive, HER2-negative breast cancer that has a specific genetic change (PIK3CA mutation). The goal is to see if adding Inavolisib to standard endocrine therapy can shrink the tumor more effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT07178171RecruitingPhase 1
QL1706 + short chemo for early triple-negative breast cancer
This trial tests a new immunotherapy drug (QL1706) combined with a short course of common chemotherapy (anthracyclines or taxanes) for people with early-stage triple-negative breast cancer. The goal is to see if this combination is safe and helps shrink the tumor before surgery.
Xi'an, ShaanxiAges 18–70 - NCT07182682RecruitingPhase 3
Sunvozertinib after surgery for early-stage NSCLC with certain EGFR mutations
This trial tests the drug sunvozertinib given after surgery to see if it prevents lung cancer from coming back. It is for people with early-stage non-small cell lung cancer that has specific changes in the EGFR gene (exon20 insertion or PACC mutations).
BeijingAges 18 years+ - NCT07218432Recruiting
TheraBionic device study for hormone-positive breast cancer
This trial tests a device called TheraBionic P1, which uses low-level radiofrequency energy, for women with early-stage hormone receptor-positive, HER2-negative breast cancer. It is given before surgery to see if it can help shrink the tumor.
Clarkston, MichiganAges 22 years+ - NCT07263451Recruiting
Testing a new treatment for small, early breast cancers
This study tests if a new treatment called IRE (irreversible electroporation) can safely treat small, early-stage breast cancers. It's for people with a single, small tumor that has not been treated yet.
Hangzhou, ZhejiangAges 18 years+ - NCT07354165Recruiting
Financial burden in early breast cancer patients
This study looks at the financial challenges people with early-stage breast cancer face during treatment. Researchers want to understand how costs affect patients so they can find ways to help.
NaplesAges Any age - NCT07386444Recruiting
Breathing exercises for breast cancer patients on chemo
This trial tests whether special breathing exercises can help breast cancer patients feel better during chemotherapy. You would do simple, guided breathing workouts to strengthen your breathing muscles.
Columbus, OhioAges 18 years+ - NCT01042379RecruitingPhase 2
Adaptive drug trial for newly diagnosed breast cancer
This study tests personalized, changing treatment plans (given before surgery) to find better options for your specific breast tumor. You may be asked for extra breast-tissue testing to help match you with the most suitable study drug(s).
Birmingham, AlabamaAges 18 years+ - NCT00823654Recruiting
Blood tests during treatment to track ovarian egg supply
This study measures blood biomarkers to understand how breast cancer treatment affects a person’s future fertility (ovarian reserve). It may help patients learn more about egg supply changes after chemotherapy and hormone-related treatments.
Basking Ridge, New JerseyAges 18–44 - NCT07455188Recruiting
Switching targeted therapies for advanced HER2-positive breast cancer
This trial tests whether switching between two targeted therapy combinations can help women with HER2-positive advanced breast cancer that has progressed after previous treatments. It aims to find a new effective option for people who have already tried one or two lines of therapy.
Zhejiang, HangzhouAges 18 years+ - NCT07478900Recruiting
Tattoo marking breast tumors before chemo
This trial tests a simple method: marking the tumor with a small tattoo before chemotherapy. The tattoo helps surgeons find the exact spot for lumpectomy after the tumor shrinks, so you can keep more of your breast.
Bhubaneswar, OdishaAges 18–75 - NCT07507890Recruiting
Nipple-sparing mastectomy through one armpit incision
This trial tests a less invasive surgery for early-stage breast cancer that removes breast tissue through a single small cut in the armpit while keeping the nipple. It may be an option for women with small to medium breasts who are candidates for immediate breast reconstruction.
Candiolo, TurinAges 18 years+ - NCT07581834RecruitingPhase 2
Dalpiciclib plus hormone therapy for early hormone-positive breast cancer
This study tests whether adding a new drug called dalpiciclib to standard hormone therapy improves outcomes for women with early-stage breast cancer that is hormone-receptor positive. The goal is to see if this combination is more effective and safe than hormone therapy alone.
Fuzhou, FujianAges 18 years+ - NCT07372261Enrolling by invitation
Predicting breast cancer spread risk
This study tests a method to predict if early-stage breast cancer might spread to other parts of the body. It uses leftover tumor tissue to help doctors plan your treatment.
San Giovanni Rotondo, FGAges 18 years+ - NCT06650748Enrolling by invitationPhase 2
A study of hormone therapy with or without a targeted drug for breast cancer
This trial tests if adding a targeted drug (CDK4/6 inhibitor) to hormone therapy works better than hormone therapy alone for women with a certain type of breast cancer (HR+/HER2-). The study measures the activity of tumor cells (Ki-67) to help decide treatment.
BeijingAges 18–70 - NCT07310420RecruitingPhase 1
Zoladex injection for ovarian suppression in advanced breast cancer
This trial tests a single injection of Zoladex (goserelin) to see how well it suppresses ovarian function in premenopausal women with HR+, HER2- advanced breast cancer. It may be an option if you are still having periods and your cancer has spread or cannot be removed by surgery.
Hot Springs, ArkansasAges 18–55 - NCT06143553RecruitingPhase 3
Paclitaxel micelles for metastatic breast cancer
This trial tests a new form of paclitaxel (a chemotherapy drug) for metastatic breast cancer that is HER2-negative. It may be an option if your cancer has returned or not improved after 2 to 4 previous treatments.
Nanjing, JiangsuAges 18 years+ - NCT06155305Recruiting
Organoid drug test before breast cancer surgery
This trial uses a lab-grown mini-tumor (organoid) from your biopsy to test which chemotherapy drugs work best for your cancer before you have surgery. The goal is to personalize your treatment and improve outcomes.
Hangzhou, ZhejiangAges 18–70 - NCT06088771RecruitingPhase 1/Phase 2
Study of dupilumab and cemiplimab before lung cancer surgery
This study tests two drugs, dupilumab and cemiplimab, given before surgery for early-stage lung cancer. The goal is to see if these immune-boosting medicines can shrink the tumor and improve outcomes.
New York, New YorkAges 18 years+ - NCT06279364RecruitingPhase 3
Testing SKB264 vs standard chemo for advanced triple-negative breast cancer
This trial tests a new drug called SKB264 against standard chemotherapy options for people with advanced triple-negative breast cancer who have not yet received chemotherapy for their advanced disease. The goal is to see if SKB264 works better than the usual treatments.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05323409Recruiting
Better overall care for certain cancer patients
This study looks at how to improve day-to-day support and coordination between cancer doctors and primary care doctors for people with certain early cancers. It may help if you have other ongoing health problems (like diabetes or high blood pressure) or lifestyle factors that need ongoing management during cancer treatment.
Houston, TexasAges 18 years+ - NCT05219695Recruiting
Imaging and controlled heat treatment for breast tumors
This study uses special ultrasound-like imaging to guide a controlled heat treatment during planned surgery for certain breast tumors. It may help doctors better see and treat tumor tissue while you already have surgery scheduled.
New York, New YorkAges 18 years+ - NCT06732323RecruitingPhase 3
Study of ESG401 for triple-negative breast cancer that has spread
This trial tests a new drug, ESG401, for people with triple-negative breast cancer that has come back or spread and cannot be removed by surgery. It compares ESG401 to standard chemotherapy options to see which works better.
BeijingAges 18 years+ - NCT07380984RecruitingPhase 2
Immunotherapy and radiation for early-stage nasal-type lymphoma
This trial tests a combination of an immunotherapy drug (PD-1 antibody, which helps your immune system fight cancer) and radiation therapy for people with early-stage nasal-type NK/T-cell lymphoma. It aims to see if this approach is safe and effective as a first treatment.
ShanghaiAges 18 years+
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Common questions
- Are there clinical trials for early-stage breast cancer?
- Yes. Clin2 currently lists 125 recruiting early-stage breast cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a early-stage breast cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a early-stage breast cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.