Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,378 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT05641662Recruiting
Video games that get you moving for heart failure inactivity
This study tests whether playing “exergames” (motion-based video games) can help people with heart failure who are mostly inactive spend less time sitting. It checks whether the games are safe and practical and whether they can improve activity over time.
PortoAges 18 years+ - NCT05655065Recruiting
Testing higher blood pressure to protect kidneys in shock
This trial studies whether aiming for a higher average blood pressure (using medicines) can better protect kidney function in critically ill adults with shock. You may be asked to have close kidney and heart monitoring while receiving blood-pressure support.
AngersAges 18 years+ - NCT05642260Recruiting
Fall-prevention program after knee replacement for older women
This trial tests whether a structured fall-prevention program can reduce the number of falls in older women after total knee replacement surgery. It may help you stay safer as you recover and move around.
Kuwait CityAges 60 years+ - NCT05671133Recruiting
Decision support to help clinicians prevent suicide risk
This study looks at whether a computer tool helps clinicians respond in a way that reduces suicidal thoughts or behaviors. If you’re attending the APS and can consent, the study may involve your information being used to improve clinician decision-making.
Boston, MassachusettsAges 18 years+ - NCT05667246Enrolling by invitation
Caffeine and oral terbinafine for toenail fungus
This trial studies how drinking caffeine affects people who are starting oral terbinafine for toenail fungus. It may help explain whether caffeine changes side effects or effectiveness while you take the medicine.
New York, New YorkAges 18 years+ - NCT05664516RecruitingPhase 2
Oxytocin treatment study for binge eating disorder adults
This Phase 2 trial tests whether oxytocin (a hormone-like medication) can reduce binge-eating symptoms in adults with binge-eating disorder (including related conditions like bulimia or certain feeding/eating disorders). You may be eligible if your symptoms match the trial’s specific diagnosis rules and you can safely take the study medication.
Boston, MassachusettsAges 18–70 - NCT05641116Recruiting
Exercise plus education program for long-lasting Lyme-related symptoms
This trial tests whether a combined program of adapted exercise and therapeutic education can improve long-lasting symptoms that are thought to be related to Lyme disease. It may help people who have symptoms for over 6 months and are not very active currently.
Clermont-FerrandAges 18 years+ - NCT05649059RecruitingPhase 4
Cannabidiol study for social anxiety symptoms
This trial studies whether cannabidiol (CBD) helps improve social anxiety symptoms. You may be able to join if you are an adult with significant social anxiety and meet medication and health safety requirements.
Cambridge, MassachusettsAges 18–55 - NCT05637294Recruiting
Compare night-only versus full-time splinting for carpal tunnel
This study looks at whether wearing a wrist splint only at night works as well as wearing it full-time for carpal tunnel syndrome (CTS). It may help you find the most helpful and practical splint schedule to reduce symptoms.
HelsinkiAges 18 years+ - NCT05641987Enrolling by invitation
School staff well-being program survey study
This study tests an “educator well-being program” to see how it affects staff well-being. You may be able to participate if you work as school staff and are 18 or older when the survey is given.
Farmington, ConnecticutAges 18 years+ - NCT04167033Recruiting
Checking heart rhythm timing in women with premature ovarian insufficiency
This study measures how quickly the heart “recharges” between beats (often shown as QT timing). It compares women with premature ovarian insufficiency to healthy women to understand whether ovarian insufficiency is linked to heart rhythm differences.
BordeauxAges 18–40 - NCT05630794RecruitingPhase 1
Safety study of ONC201 for preventing colon polyps
This trial tests a drug called ONC201 to see if it can safely help prevent colon polyps from coming back in people at high risk. You will take the drug for about 12 weeks and have a second colonoscopy to check results.
Ann Arbor, MichiganAges 18 years+ - NCT05623020RecruitingPhase 3
New treatment for newly diagnosed transplant-ineligible myeloma
This Phase 3 study compares a three-drug combination (elranatamab, daratumumab, and lenalidomide) versus a standard three-drug treatment (daratumumab, bortezomib, lenalidomide, plus dexamethasone). It aims to see which plan works better for people newly diagnosed with multiple myeloma who cannot get a stem cell transplant.
Jupiter, FloridaAges 18 years+ - NCT05635929Recruiting
Topical treatment to reduce mouth sores during or after radiation
This study tests a new cream/gel applied to the mouth to lower the chance of severe mouth sores in people receiving radiation for head and neck cancer. It also looks at how treatment affects quality of life using patient questionnaires.
Madrid, MadridAges 18 years+ - NCT05602636RecruitingPhase 4
Nerve-block pain options during forearm surgery
This trial compares three ways to control pain during forearm surgery: different nerve blocks versus using a PCA pain pump. It may help find the approach that gives better pain relief and comfort after surgery, especially for longer procedures.
DamiettaAges 18–70 - NCT05600868Enrolling by invitation
Testing dual attention during EMDR therapy for PTSD
This study tests whether adding “dual attention” to EMDR therapy helps people with high PTSD symptoms. If you have significant PTSD symptoms, this approach may improve how well the therapy works, but it depends on safety and recent treatment history.
Pozuelo de Alarcón, MadridAges 18–65 - NCT05598112RecruitingEarly Phase 1
Oral stool-based microbiome treatment for healthy aging
This early-stage study tests whether changing the gut bacteria using an oral stool-based treatment (called oral FMT) can improve health in older adults. It aims to see if this approach affects aging-related changes, including gut and body function.
Beijing, Beijing MunicipalityAges 70–85 - NCT05612750Recruiting
Online therapy for chronic pain: CBT vs one-session relief
This study compares two online treatments for chronic pain: an 8-session cognitive behavioral therapy (CBT) program versus a single “empowered relief” session. It aims to see which approach helps people manage pain better over time.
Phoenix, ArizonaAges 18 years+ - NCT05606991Enrolling by invitation
Testing how CPAP affects brain waste clearance during sleep
This study looks at how stopping CPAP for 14 nights affects “brain waste clearance,” a process your brain uses to clear byproducts during sleep. It is testing whether using CPAP versus stopping it changes this brain cleanup in adults with severe obstructive sleep apnea (OSA).
Macquarie Park, New South WalesAges 35–65 - NCT05635175Recruiting
Hip abductor training for women with stress urine leakage
This trial tests whether specific hip muscle exercises can reduce stress urinary incontinence (urine leaks with activities like coughing or exercise). If it works, it could improve bladder control using perineal (pelvic-area) rehabilitation plus hip-focused training.
CaenAges 18 years+ - NCT05626374Enrolling by invitation
Remote check-in tool to reduce dropout in training
This study tests whether adding a remote, self-report tool for distress (how overwhelmed or unwell someone feels) improves how many people complete a vocational training program. It’s meant to support people using the usual case management, but with extra remote check-ins.
Barrie, OntarioAges 18–49 - NCT05621460Recruiting
Water carbonation and how well you tolerate standing up
This study tests whether drinking carbonated (fizzy) water changes how well your body handles standing up without feeling faint. If you are healthy and don’t have certain heart or nerve problems, you may be able to take part.
Burnaby, British ColumbiaAges 19–50 - NCT05603650Recruiting
Mouthwash study for healthy bacteria in your mouth and gut
This study tests how a mouthrinse changes the helpful bacteria in your mouth and stomach/gut. You may need several visits and phone follow-ups to see how your microbiome shifts over time.
Irvine, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,378 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.