Clinical trials
Esophageal Neoplasms clinical trials
Below are recruiting esophageal neoplasms clinical trials, each written for real people, not researchers. We’re tracking 54 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07114601RecruitingPhase 1
Study of LY4257496 for people with GRPR-positive solid tumors
This trial tests a new drug, LY4257496, in people with certain types of cancer that have a protein called GRPR on their cells. The study aims to see if the drug can help shrink tumors or slow the cancer's growth.
Duarte, CaliforniaAges 18 years+ - NCT04075305Recruiting
Study measuring radiation treatment outcomes with an MR-Linac
This study follows what happens when radiation treatment is guided using an MR-Linac (a special machine that combines MRI imaging with radiation). It may help improve how radiation therapy is planned and assessed, especially for people who can safely have MRI scans.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05252078RecruitingPhase 2
Anlotinib plus an injection after esophageal cancer surgery
This Phase 2 study tests whether anlotinib tablets combined with an injection (TQB2450) can lower the risk of esophageal squamous cell cancer coming back after surgery. It may help by targeting cancer growth signals and blood-vessel formation to reduce recurrence.
Nanchang, JiangxiAges 18 years+ - NCT05624099RecruitingPhase 2
Camrelizumab plus chemoradiotherapy for advanced esophageal cancer
This study tests whether adding camrelizumab (an immune treatment) to standard chemoradiotherapy can control advanced esophageal squamous cell cancer. It is meant for people who have not had any prior whole-course cancer medicines for this cancer stage.
FuzhouAges 18–75 - NCT05944237RecruitingPhase 1/Phase 2
Early trial for advanced cancers using HTL0039732
This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.
CambridgeAges 18 years+ - NCT07035587Recruiting
A blood test to detect multiple cancers and monitor leftover tumors after treatment
This trial uses a blood test to find early signs of cancer or leftover tumor cells after treatment. It may help people with certain cancers or those with non-cancerous growths understand their condition better.
SeoulAges 19 years+ - NCT07213791RecruitingPhase 1
Study of a new drug for FAP-positive cancers
This trial tests a new drug (LY4337713) for cancers that have a specific protein called FAP on their surface. It may be an option for people whose cancer has continued to grow after standard treatments.
Newport Beach, CaliforniaAges 18 years+ - NCT04780256Recruiting
Study of removing digestive tumors with an endoscopy procedure
This trial looks at people (18 or older) who already had a digestive tract tumor removed using an endoscopy procedure. It may help doctors learn how this approach works and what outcomes to expect after removal.
Reggio Emilia, REAges 18–100 - NCT05698992Recruiting
Rehab program after surgery for esophageal or stomach cancer
This trial tests a rehabilitation and recovery program for people with esophageal or stomach cancer who are planning curative surgery at Skåne University Hospital. It may help you regain strength and function after treatment, using a structured recovery approach.
Lund, LundAges 18 years+ - NCT02530983Recruiting
Survey study for people after esophagus surgery
This study is a survey. It asks people about their experiences after esophagus surgery (either removing part of the esophagus or rebuilding it). It may help doctors understand what happens to patients over time and improve future care.
Rochester, MinnesotaAges 18 years+ - NCT06476678Recruiting
Testing a new ablation knife for esophageal growths
This study tests a new tool that uses radiofrequency energy to remove precancerous growths from the esophagus. It may be an option if you have a surface-level polyp in your esophagus that hasn't been treated before.
Houston, TexasAges 18 years+ - NCT06070376Recruiting
Comparing two stents for esophageal cancer swallowing problems
This study compares two types of stents (metal tubes) placed in the esophagus to help people with advanced esophageal cancer swallow more easily. Both stents are designed to keep the esophagus open and improve quality of life.
São Paulo, São PauloAges 18 years+ - NCT06380816RecruitingPhase 1/Phase 2
Study of UCB4594 for advanced cancers with HLA-G marker
This trial tests an experimental drug called UCB4594 for people with certain advanced cancers that have not responded to standard treatments. The goal is to see if the drug is safe and effective against tumors that have a specific marker called HLA-G.
LondonAges 18 years+ - NCT04389632RecruitingPhase 1
Sigvotatug vedotin for advanced solid tumors that spread
This early-stage study tests a drug called sigvotatug vedotin in people with advanced solid cancers that cannot be removed or have spread. It aims to see how well the treatment works and what side effects it causes.
Anchorage, AlaskaAges 18 years+ - NCT04654975Recruiting
Metastatic brain tumors after esophagus surgery study
This study looks at people who had esophageal cancer surgery and later developed brain metastases. It may help doctors better understand who benefits from treatment planning after the original cancer surgery.
Houston, TexasAges Any age - NCT06469944RecruitingPhase 1/Phase 2
Study of drug combinations for stomach or esophagus cancer
This trial tests new combinations of drugs alongside standard chemotherapy for people with advanced stomach or esophagus cancer that has not been treated yet. It aims to see if these combinations can shrink tumors or slow down the cancer better than current options.
Tucson, ArizonaAges 18 years+ - NCT06445972RecruitingPhase 1/Phase 2
Testing combination therapies for advanced stomach or esophageal cancer
This study tests new drug combinations for people with advanced stomach or esophageal cancer that worsened after first treatment. It aims to find better options for those whose tumors lack HER2.
Tucson, ArizonaAges 18 years+ - NCT05804331Recruiting
Endoscopy treatment study for large upper stomach/throat lesions
This trial studies a specialized endoscopy procedure to remove larger abnormal growths in the upper digestive tract. It may help people whose lesion size and depth make certain removal techniques a better fit.
Sydney, New South WalesAges 18 years+ - NCT05875870Recruiting
Bright light and exercise program for lung or esophageal cancer
This trial tests whether a structured bright-light exposure routine combined with a specific exercise program can help people with newly diagnosed lung or esophageal cancer. You may be eligible if you’re in early-to-middle cancer stages and able to safely participate in walking-based activities.
Taipei City, TaipeiAges 20 years+ - NCT07482566Recruiting
Comparing two surgeries for advanced gastroesophageal junction cancer
This trial compares two types of stomach-removing surgeries (total vs. partial gastrectomy) in people with a certain kind of advanced gastroesophageal junction cancer. The goal is to find out which surgery leads to better outcomes.
Istanbul, IstanbulAges 18–90 - NCT06084897RecruitingPhase 2
Radiotherapy for metastatic esophageal cancer responding to immunotherapy
This trial tests whether adding radiotherapy can help people with metastatic esophageal cancer that has already responded well to initial treatment with immunotherapy and chemotherapy. It may offer a way to improve outcomes for those whose cancer has not progressed after 2-4 cycles of first-line treatment.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03222895Recruiting
Mapping lymph node spread in resectable esophageal cancer
This study looks at how esophageal (or esophagus-stomach junction) cancer spreads to nearby lymph nodes. Results may help doctors understand where cancer cells are likely to be, potentially improving future surgery planning.
Houston, TexasAges 18 years+ - NCT05800054Recruiting
Nutrition support program for people with esophageal cancer
This trial tests whether an “NST whole-course” nutrition management plan can improve nutrition status and reduce side effects during treatment for stage II–III esophageal cancer. It may help you stay stronger and tolerate cancer therapy better by carefully monitoring and adjusting nutrition.
Nanjing, JiangsuAges 18–75 - NCT06086457RecruitingPhase 3
Immunotherapy plus chemo with or without radiation for esophageal cancer
This trial tests whether adding radiation therapy to a standard treatment (immunotherapy plus chemotherapy) can help people with advanced esophageal cancer that has spread to up to two organs. The goal is to see if the combination improves outcomes.
Beijing, Beijing MunicipalityAges 18 years+
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Esophageal Neoplasms trials by city
Studies with a site in or near these metro areas.
Esophageal Neoplasms trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for esophageal neoplasms?
- Yes. Clin2 currently lists 54 recruiting esophageal neoplasms studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a esophageal neoplasms trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a esophageal neoplasms trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.