Clinical trials
Fontan clinical trials
Below are recruiting fontan clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06762964RecruitingPhase 2
Dapagliflozin for Failing Fontan Circulation
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Rochester, MinnesotaAges 18 years+ - NCT05206955RecruitingPhase 3
Tadalafil versus placebo for Fontan circulation problems
This study tests whether tadalafil (a daily pill) can improve blood flow and protect organs in adults who have had Fontan surgery. Participants will either receive tadalafil or a placebo, and they will be monitored during a planned heart catheter procedure.
Rochester, MinnesotaAges 18 years+ - NCT06324396RecruitingPhase 1
Improving drug dosing for single ventricle patients with liver disease
This trial studies how the drugs sildenafil and pravastatin work in people with a single ventricle heart condition who have had the Fontan surgery and may have related liver problems. The goal is to find the best doses based on liver function.
Kansas City, MissouriAges 8 years+ - NCT07220226Recruiting
Fontan circulation and venous compression study
This trial looks at how blood flow works in people with Fontan circulation, who have a unique heart surgery. It aims to understand vein compression and may help guide future care.
Dallas, TexasAges 18–45 - NCT07482943RecruitingPhase 4
Dapagliflozin for heart function after Fontan procedure
This trial tests whether dapagliflozin, a diabetes drug that also helps the heart, can improve exercise ability and heart function in people who have had the Fontan procedure for a single ventricle heart defect.
Hong KongAges 12 years+ - NCT06258382Recruiting
Fontan circulation and reproductive health study
This study looks at reproductive health in adults with Fontan circulation (a type of heart surgery) and their partners, using questionnaires. It aims to understand how this heart condition affects reproductive health and family life.
Lund, Skåne CountyAges 18 years+ - NCT07009132Recruiting
Liver function test for adults with Fontan or heart failure
This study tests a simple liver function test (called dual cholate clearance) to see how well it works in adults with a Fontan circulation or right heart failure. It aims to help doctors better detect liver problems in these heart conditions.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07535203Recruiting
Heart Surgery Outcomes in Single-Ventricle Disease
This study follows children with a rare heart condition (univentricular heart) who need multiple surgeries, including a procedure called Fontan. Researchers want to understand how different blood-flow patterns after surgery affect long-term health and outcomes.
Jakarta, DKI JakartaAges Any age - NCT07029230Recruiting
Blood test during heart surgery to predict heart failure in kids
This study looks at a substance called sST2 in the blood of children having heart surgery. The goal is to see if sST2 levels can help doctors predict heart failure after surgery.
Zurich, Canton of ZurichAges Up to 18 years - NCT05918211RecruitingPhase 3
Udenafil test during exercise for teens with Fontan circulation
This trial tests whether udenafil helps teens and young people with Fontan circulation do better on exercise and breathing-related measures over time. You’d need to be on blood-thinning medicine, and be able to complete exercise testing safely.
Phoenix, ArizonaAges 12–18 - NCT07742046Enrolling by invitation
Heart blood flow scan for congenital heart disease
This study tests a new MRI technique to measure blood flow in the heart without invasive procedures. It may help doctors better understand and manage congenital heart conditions.
LausanneAges 16 years+ - NCT03052283Recruiting
Abdominal symptom score test for people with cystic fibrosis
This trial helps create and check a patient-friendly questionnaire that measures abdominal (belly) involvement in cystic fibrosis. It may help your care team better track symptoms over time.
Brandenburg an der HavelAges Any age - NCT05213598Recruiting
Biomarker study for liver disease after Fontan surgery
This study looks for blood and/or test markers that can better show how severe liver disease is in people who had the Fontan heart procedure. It also involves medical imaging and/or a liver biopsy or related procedures to help evaluate those markers.
Bethesda, MarylandAges 18–100 - NCT05563376Recruiting
Clinic visit for people with Fontan heart circulation
This study is for people born with a single-ventricle heart condition who now live with a Fontan circulation. It mainly focuses on having a dedicated clinic visit (“Fontan clinic session”) and checking how that care works for you.
ErlangenAges 6–60 - NCT06150950Recruiting
Exercise rehab for Fontan failure
This trial tests if a supervised exercise program (cardiac rehabilitation) can help people who have had a Fontan procedure and are now experiencing heart failure symptoms. It aims to improve your strength, stamina, and overall well-being.
Stanford, CaliforniaAges 18 years+ - NCT06575582Recruiting
Digital navigators for mental health apps
This trial tests if a digital navigator can help you learn to use mental health apps. It aims to improve your skills and comfort with these tools.
Brandenburg an der Havel, BrandenburgAges 18 years+ - NCT06735521Recruiting
Heart MRI stress test for Fontan circulation
This study uses a special heart MRI with a medicine that stresses the heart (like exercise) to look at blood flow in people who have had the Fontan surgery. The goal is to better understand how the heart works after this surgery.
StockholmAges 18 years+ - NCT06918795Recruiting
Fontan Fitness Trial: Home exercise for better heart health
This study tests whether a home-based exercise training program can improve fitness in people with Fontan circulation. Participants will do regular aerobic exercise and be monitored for changes in heart and lung function over time.
Philadelphia, PennsylvaniaAges 10–17 - NCT06932081Recruiting
Study of SGLT2i in adults with congenital heart disease
This trial is a registry that follows adults with congenital heart disease who have started taking an SGLT2 inhibitor medication. The goal is to learn how well this treatment works for this group of patients.
Baltimore, MarylandAges 18 years+ - NCT07073612Recruiting
Fontan stent study for liver stiffness and exercise
This study looks at whether placing a stent in the Fontan blood vessel can improve liver health and exercise ability in teenagers and young adults. If you are between 12 and 21 years old and need a stent in your Fontan pathway, you may be able to join.
Los Angeles, CaliforniaAges 12–21 - NCT07658547Enrolling by invitation
AI Chatbots for Mental Health
This trial tests if an AI chatbot can help people with a diagnosed mental illness. It aims to find a new way to support your mental health.
Rüdersdorf, BrandenburgAges 18 years+
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Common questions
- Are there clinical trials for fontan?
- Yes. Clin2 currently lists 21 recruiting fontan studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a fontan trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a fontan trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.