Clinical trials · North Carolina
Fracture clinical trials in North Carolina
We’re tracking 26 recruiting fracture studies with a site in North Carolina — including Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in North Carolina
- NCT04299022Recruiting
Study of ViviGen bone graft for fracture healing
This study follows people who are treated with a bone graft called ViviGen to help heal fractures, delayed healing, or non-healing (“non-union”) bone problems. The goal is to check how safe it is and how well it works in real-world orthopaedic care.
Durham, North CarolinaAges Any age - NCT06438640Recruiting
My Anesthesia Choice for Hip Fracture Surgery
This trial tests a new way to help you and your doctor talk about anesthesia options before your hip fracture surgery. The goal is to see if this approach improves your experience and recovery.
Winston-Salem, North CarolinaAges 50 years+ - NCT06455085Recruiting
Preventing future fractures after a bone break
This study aims to help adults over 50 who had a recent bone fracture (from a minor fall) get better follow-up care to prevent future fractures. You will work with a nurse or coordinator to connect with your primary care doctor and learn about bone health options.
Chapel Hill, North CarolinaAges 50 years+ - NCT04615104Recruiting
Study of pelvic and hip-joint bone fractures
This study is observing people with pelvic ring and acetabular (hip-joint socket) fractures to better understand what happens over time. It may help doctors improve care, even though it does not test a new treatment.
Charlotte, North CarolinaAges 18 years+ - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Charlotte, North CarolinaAges 18 years+ - NCT02664337Enrolling by invitation
Study of what people prefer in joint and fracture treatments
This study asks patients (or parents/caregivers, for children’s injuries) about their preferences for different treatment options for certain joint and fracture problems. It may help clinicians choose care plans that match what patients value.
Durham, North CarolinaAges 18–85 - NCT05415384Recruiting
Cryotherapy plus surgery for broken ribs
This trial tests whether adding cryotherapy (freezing treatment to the injury area) to standard surgery for broken, displaced ribs can improve recovery. It’s for adults with multiple broken ribs who are getting a surgical stabilization procedure soon after injury.
Winston-Salem, North CarolinaAges 18–80 - NCT05851898RecruitingPhase 4
Tested medicine to prevent depression after hip or leg fractures
This trial studies whether a type of antidepressant medicine (a serotonin–norepinephrine reuptake inhibitor) can prevent depression after a lower-extremity fragility fracture that was treated with surgery. It’s mainly for older adults, and aims to see if starting this medicine early reduces later depression symptoms.
Winston-Salem, North CarolinaAges 65 years+ - NCT06249126Recruiting
Heel bone fusion for severe fractures
This trial tests whether fusing the joint just below the ankle (subtalar joint) during heel bone fracture repair helps people with severe fractures heal better. You may qualify if you have a specific type of broken heel bone and can return for follow-up visits for one year.
Chapel Hill, North CarolinaAges 18 years+ - NCT05206981Recruiting
Registry of an implanted bone-stabilizing device after trauma
This trial tracks outcomes after doctors implant the IlluminOss bone-stabilizing device for traumatic injuries. It helps researchers understand how the device performs and how well patients heal over follow-up visits, including scans.
Asheville, North CarolinaAges 50 years+ - NCT05421741RecruitingPhase 4
Antibiotic-coated nail to help prevent infection
This trial studies a special nail for certain broken shin bones to lower the chance of infection after surgery. If you qualify, the study team will help you receive the antibiotic-coated nail and will follow you closely for about a year.
Chapel Hill, North CarolinaAges 18 years+ - NCT05766670RecruitingPhase 3
Calcium and antibiotic placed inside tibia nail for open fractures
This Phase 3 study tests whether a calcium/antibiotic “depot” released from an intramedullary nail can lower infection risk in certain open tibia fractures. It may help by delivering antibiotics right at the fracture area while the nail fixes the bone.
Charlotte, North CarolinaAges 18 years+ - NCT05889559Recruiting
Testing a fluid drainage method to detect leg pressure problems
This study looks at a special drainage measurement (“tissue ultrafiltration”) to better detect and treat acute compartment syndrome, a dangerous increase in pressure in the leg after major injury. It may help doctors identify who needs urgent treatment and improve outcomes after severe leg fractures or crush injuries.
Charlotte, North CarolinaAges 18–60 - NCT06179004RecruitingPhase 3
Numbing medicine comparison for wrist surgery pain
This study compares two types of numbing medicine (bupivacaine and liposomal bupivacaine) given near the collarbone before wrist surgery to see which provides better pain relief afterward.
Chapel Hill, North CarolinaAges 18 years+ - NCT06286670Recruiting
Comparing one versus two implants for thigh bone breaks
This trial is testing whether using two metal implants to fix a broken thigh bone (near the knee) works better than using just one. It aims to help patients with certain types of fractures that need surgery.
Chapel Hill, North CarolinaAges 18 years+ - NCT05131685Recruiting
Child wrist fracture study comparing treatment for certain breaks
This study looks at treatment for children’s wrist (distal radius) fractures that are very displaced but not involving the growth plate. It may help doctors find the best way to reset and stabilize the bone when the fracture is recent.
Chapel Hill, North CarolinaAges 4–10 - NCT04678154RecruitingPhase 3
Antibiotic trial for severe open fractures of the leg or foot
This trial tests a new way of giving antibiotics to people with severe open fractures in the leg, ankle, or foot. The goal is to see if it helps prevent infections after surgery.
Chapel Hill, North CarolinaAges 18–64 - NCT06010433Recruiting
CERAMENT G treatment tracking study
This study tracks how well the CERAMENT G device works for people getting it as part of their treatment. It helps doctors gather real-world safety and effectiveness information.
Charlotte, North CarolinaAges 18 years+ - NCT06737237Enrolling by invitation
Nerve block vs. local numbing for collarbone surgery
This trial compares two ways to numb the area during collarbone surgery: a nerve block (cervical plexus block) or local anesthetic injections. The goal is to see which provides better pain relief and recovery.
Marine Corps Base Camp Lejeune, North CarolinaAges 18–64 - NCT06921707Recruiting
WounDx test for healing decisions in large wounds
This trial tests a new tool called WounDx that helps doctors decide the best way to treat large wounds on arms, legs, or buttocks. It may help your wound heal better by guiding your care.
Durham, North CarolinaAges 18–65 - NCT04921865Recruiting
Study of a 2.7 clavicle plate or hook plate
This case series looks at how well a specific clavicle plate or hook plate system works after surgery for certain collarbone injuries. It may help surgeons understand which injuries benefit most and what to expect for recovery and outcomes.
Winston-Salem, North CarolinaAges 18 years+ - NCT05046600Recruiting
Hand and wrist implant registry for eligible adult patients
This registry collects information about people who need hand or wrist surgery using specific Arthrex implants. It helps the company and doctors learn how these implants are used and how patients do during healing.
Durham, North CarolinaAges 18 years+ - NCT05603728Recruiting
Follow-up study for Exactech shoulder implants after surgery
This study follows people who get (or already had) a shoulder replacement to see how the implant is doing over time. It may help improve future care by tracking long-term performance and safety.
Durham, North CarolinaAges 21 years+ - NCT07104279Recruiting
Zimmer Biomet hip implant follow-up study
This study is for people who need a hip replacement for the first time. It is testing a specific hip implant system called the Z1 Hip System and will follow patients to see how well it works over time.
Charlotte, North CarolinaAges 18 years+
Where these studies are running in North Carolina
Institutions with a site for the recruiting fracture studies listed above.
- Atrium Health Wake Forest Baptist Medical Center (Wake Forest Baptist) · 8 studies
- Carolinas Medical Center/Levine Cancer Institute · 7 studies
- University of North Carolina at Chapel Hill · 7 studies
- Atrium Health Cabarrus · 4 studies
- OrthoCarolina Research Institute · 3 studies
- Wake Forest University Health Sciences · 3 studies
- Duke University · 2 studies
- Duke University Medical Center · 2 studies
What taking part in a fracture study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Common questions
- Are there fracture clinical trials in North Carolina?
- Yes. We're currently tracking 26 recruiting fracture studies with a site in North Carolina, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a fracture study in North Carolina?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in North Carolina to take part?
- Not necessarily. These studies have a site in North Carolina, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a fracture trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New fracture studies open in North Carolina regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.