Clinical trials
Gastrointestinal clinical trials
Below are recruiting gastrointestinal clinical trials, each written for real people, not researchers. We’re tracking 480 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05292989Recruiting
Using a frailty checklist to help older people choose care
This study looks at how a personalized “frailty” checklist can help older adults (65+) understand their health and make better choices. You may be asked to complete questionnaires and a frailty-type assessment to see if the approach works for you.
Woolloongabba, QueenslandAges 65–100 - NCT05307367Recruiting
Study exercise and body muscle changes in advanced lung cancer
This study looks at why cancer can cause loss of muscle in people with advanced non–small cell lung cancer, and whether exercise can improve or explain those muscle changes. You may be asked to do physical testing and answer questionnaires while receiving standard palliative cancer treatment.
Copenhagen, DKAges 18–100 - NCT05366816RecruitingPhase 2
Blood test–guided sunitinib or regorafenib for GIST
This study uses a blood test (ctDNA) to look for specific tumor DNA changes, then guides treatment with sunitinib or regorafenib in people with GIST that has spread or cannot be removed by surgery. It aims to see whether this ctDNA-guided approach improves outcomes compared with standard decision-making.
Miami, FloridaAges 18 years+ - NCT05375643Recruiting
Get help enrolling in a genomics-based cancer trial
This study helps support people who are from groups less represented in cancer genetics research to get enrolled in genomics-based cancer trials. If you’re starting a new patient visit for an advanced stomach, blood, or lung cancer, this may guide you through options that use your genetic information.
Boston, MassachusettsAges 18 years+ - NCT05381038RecruitingPhase 1/Phase 2
Personalized azacitidine combinations for breast or stomach cancer
This Phase 1/2 trial tests different combinations that include azacitidine, chosen based on your tumor’s lab “response markers” and past drug-sensitivity screening. It aims to find safer dosing and see whether these personalized combinations can shrink solid tumors such as breast or stomach cancer.
SingaporeAges 21–99 - NCT05406167Recruiting
Tracking quality of life during radiotherapy with a new system
This study collects information about how you feel and how treatment is delivered while you receive radiotherapy using the RefleXion Medical radiotherapy system. It may help doctors improve care and better understand what affects quality of life during treatment.
Duarte, CaliforniaAges Any age - NCT05408897Recruiting
Blood test to predict risk after surgery for high-risk GIST
This study uses a “liquid biopsy” blood test to look for leftover cancer signals after surgery. It aims to predict how well treatment will work and how likely the cancer is to come back in people with high-risk GIST.
Beijing, Beijing MunicipalityAges Any age - NCT05438459RecruitingPhase 1/Phase 2
Pembrolizumab-based treatment given through an abdominal port
This early-phase study tests an antibody-based treatment given directly into the abdomen (through a port) for advanced stomach or pancreatic cancer that has spread in the lining of the belly or is causing abdominal fluid buildup. It’s designed for patients whose cancer has not responded to earlier chemotherapy, with the goal of improving cancer control and shrinking belly fluid.
Fukuoka, FukuokaAges 20 years+ - NCT05439135Recruiting
Fecal microbiome transplant to treat malnutrition after GI surgery
This trial tests whether “washed microbiota transplant” (a treatment using processed gut bacteria) can improve malnutrition in adults who developed it after certain upper gut surgeries. It may help by restoring helpful gut bacteria, but you must meet several medical and safety checks.
Nanjing, JiangsuAges 18 years+ - NCT05455359RecruitingPhase 4
Tube-fed children at high risk for aspiration pneumonia
This Phase 4 study looks at gastrointestinal movement (dysmotility) and how it may increase the risk of aspiration pneumonia in children who eat through a tube and have swallowing safety problems. It may help doctors better prevent lung infections in children who cough/choke and need suction often.
Boston, MassachusettsAges 5–21 - NCT05461664Recruiting
Avapritinib for advanced GIST without PDGFRA exon 18 changes
This trial studies avapritinib, a targeted medicine, for people with advanced or returning gastrointestinal stromal tumors (GIST) whose tumor does not have PDGFRA exon 18 mutations. It aims to see how well the drug can shrink tumors or control the disease.
GuangzhouAges 18 years+ - NCT05468008Recruiting
Study of endoscopic submucosal removal (ESD)
This trial is checking outcomes for adults who are scheduled to have a procedure called endoscopic submucosal dissection (ESD), done through an endoscope. If you’re already planned for ESD and have no reasons you can’t have endoscopy, you may be able to join.
Orlando, FloridaAges 18 years+ - NCT05493215RecruitingPhase 2
Imatinib drug-monitoring for GIST with specific gene changes
This Phase 2 trial studies how to adjust and monitor imatinib (a targeted cancer medicine) based on drug levels in the blood. It may help people with GIST that has certain KIT or PDGFRA mutations but not the PDGFRA D842V type.
Lexington, KentuckyAges 18 years+ - NCT05500391RecruitingPhase 2
Testing whether remote nurse monitoring works like in-person checks
This Phase 2 study compares two ways of checking your cancer follow-up: a doctor or nurse visits in person versus remote monitoring by phone and imaging. The goal is to see whether remote monitoring can safely replace or match in-person care for certain low-risk cancers and after surgery.
AmiensAges 18 years+ - NCT05547919Recruiting
PSMA scan study for newly diagnosed gut cancer
This study looks at a specific body scan target (PSMA) in newly diagnosed gut cancers to better understand the tumor and guide future care. You may be asked to provide tumor tissue and get a PSMA PET/CT scan, and the results could help identify who may benefit from PSMA-based treatments.
Würzburg, BavariaAges 18 years+ - NCT05606822Recruiting
Vacuum endoscopy for leaks after esophagus stomach surgery
This trial studies an endoscopic vacuum treatment (a suction device placed through an endoscope) to help heal a leak after surgery where food/drink pathways were connected (an anastomosis). If you had an esophago-gastric leak, this treatment may be part of your care plan and is being studied for effectiveness and safety.
AmsterdamAges 18 years+ - NCT05652088Recruiting
Study gut immune tissue in HIV cure efforts
This study looks at how immune tissue in the gut may be involved in curing HIV. You may be asked to have two colonoscopies while on an HIV “cure-related” treatment, so researchers can collect tissue samples to understand what’s happening in your body.
New York, New YorkAges 18–75 - NCT05661643RecruitingPhase 2
Temozolomide for GIST tumors with SDH deficiency
This trial tests how well temozolomide works and how safe it is for people with GIST (a type of stomach/intestine tumor) that is SDH-deficient and has no KIT or PDGFRα mutations. It may help by targeting tumor DNA repair weakness seen in this SDH-deficient subtype.
Seoul, SeoulAges 20 years+ - NCT05692024RecruitingPhase 1/Phase 2
Coffee and gut bacteria study after colon or rectal cancer
This early-phase study tests whether a coffee-related approach can change gut bacteria and blood “metabolites” after treatment for stage I–III colon or rectal cancer. The goal is to learn if these changes could help improve health after standard cancer treatment.
Boston, MassachusettsAges 18 years+ - NCT05735678Recruiting
Study of duodenoscope performance during routine ERCP procedures
This study checks how well a special endoscopy tool (a duodenoscope) works and records technical outcomes during ERCP or related procedures you need for your care. It may help improve future safety and performance of the equipment used in these procedures.
Rozzano, MilanoAges 18 years+ - NCT05751733Recruiting
Apatinib versus standard drug for advanced GIST after imatinib
This trial studies whether apatinib works better than the usual second-line targeted tablet for advanced gastrointestinal stromal tumor (GIST) after imatinib (or avatinib) no longer works. It may help people whose cancer has grown despite treatment or who couldn’t tolerate it.
Changsha, HunanAges 18 years+ - NCT05752071Recruiting
Stomach stimulation to help bowel recovery after major surgery
This trial tests a stomach (gastrointestinal) stimulation approach to help your bowels start working again after extensive surgery, which may cause a temporary problem called postoperative ileus. If it helps, it could mean faster recovery and less time with bowel-related complications.
AarhusAges 18 years+ - NCT05780684Recruiting
Personalized 5-FU dosing for advanced gastrointestinal cancer
This study tests whether doctors can safely find the best dose of 5-FU, a chemotherapy medicine, for people with advanced gastrointestinal cancers. The goal is to reduce side effects while still treating the cancer effectively.
Lebanon, New HampshireAges 18 years+ - NCT05782010Recruiting
Testing a hemorrhoid device for grade II or III hemorrhoids
This study tests how safe and well a hemorrhoid treatment device (PexyEazy®) works for adults with moderate-to-severe hemorrhoids (grade II–III). You may be a candidate if you fit the hemorrhoid grade and medical safety requirements and can follow the study plan.
FrölundaAges 18–84
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Common questions
- Are there clinical trials for gastrointestinal?
- Yes. Clin2 currently lists 480 recruiting gastrointestinal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastrointestinal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastrointestinal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.