Clinical trials
Gastrointestinal clinical trials
Below are recruiting gastrointestinal clinical trials, each written for real people, not researchers. We’re tracking 480 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04280510Recruiting
Study of immune-related gut illnesses in adults
This study looks at adults with immune-related stomach and intestine problems to better understand what may cause them. If you qualify, you can share information and consent to help researchers learn how these conditions work.
CréteilAges 18 years+ - NCT04354064Recruiting
Blood DNA test to see early treatment response in solid tumors
This study looks at circulating tumor DNA, which is tiny bits of DNA found in blood, to help assess how solid tumors are responding early. It uses blood samples from healthy adults who are willing to donate.
St Louis, MissouriAges 18 years+ - NCT04359836Recruiting
Study of gut bacteria in early COVID-19
This trial studies how gut bacteria (“gut flora”) may affect COVID-19 after a recent infection. If you test positive for COVID-19 soon enough, the study may help researchers understand why some people get better faster or have different symptoms.
Ventura, CaliforniaAges 18 years+ - NCT04506593Recruiting
GI Motility diagnosis registry for people with digestion movement problems
This trial is a registry, meaning it collects information about people being evaluated for problems with how the gut moves. It may help doctors better diagnose gastrointestinal motility disorders in the future.
Indianapolis, IndianaAges Any age - NCT04534543Recruiting
Imaging scans to personalize chemotherapy for liver spread of bowel cancer
This trial tests whether special liver imaging can help doctors choose or guide the best chemotherapy for people with liver metastases from gastrointestinal cancer. The study focuses on comparing imaging-based information with outcomes during common chemo treatments like CAPOX or FOLFOX.
AmsterdamAges 18 years+ - NCT04613570Recruiting
Follow-up endoscopy plan for early stomach changes
This study looks at how often and how intensely to do follow-up stomach camera exams (endoscopy) with small biopsies for people at risk of stomach cancer. It may help personalize your follow-up schedule based on your specific stomach findings.
PortoAges 45 years+ - NCT04629326Recruiting
Imaging scan that targets PD-L1 in digestive cancer
This study tests an imaging method that looks for PD-L1 (a protein linked to some cancers) in solid tumors, including gastrointestinal cancers. It may help doctors better see where PD-L1 is in the body using a scan.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04646083Recruiting
Tests how far a scope can insert in the small bowel
This trial looks at how deeply doctors can safely insert a camera scope into the ileum (a part of the small intestine) during a procedure called retrograde enteroscopy. It may help improve how the exam is done for people whose small-bowel problem wasn’t fully found by usual tests.
El Paso, TexasAges 18–90 - NCT04728516RecruitingPhase 4
Eradication treatment versus acid pills to prevent GI bleeding
This trial compares a “dual eradication therapy” (to get rid of H. pylori in the stomach) versus usual acid-reducing pills (PPIs) to lower the risk of gastrointestinal bleeding in people with recent heart artery disease treated with a stent. It may help by reducing stomach infection-related bleeding while you continue needed heart medicines.
Bozhou, AnhuiAges 18 years+ - NCT04780256Recruiting
Study of removing digestive tumors with an endoscopy procedure
This trial looks at people (18 or older) who already had a digestive tract tumor removed using an endoscopy procedure. It may help doctors learn how this approach works and what outcomes to expect after removal.
Reggio Emilia, REAges 18–100 - NCT04782557Recruiting
Ultrasound-guided blood sampling to track cancer DNA
This study uses an ultrasound-guided procedure to collect blood and check for cancer DNA (small bits of tumor material in the bloodstream). It aims to see whether this method can better track how gastric, pancreatic, or colorectal cancer responds to treatment.
Hong KongAges Any age - NCT04847063RecruitingPhase 1
Test drug heating inside the abdomen for peritoneal cancer
This Phase 1 trial tests a treatment that delivers heated chemotherapy directly into the abdomen (HIPEC) for certain cancers that have spread only within the abdominal lining. It aims to see how safely and effectively this approach works, especially when doctors can remove as much tumor as possible.
Bethesda, MarylandAges 18–120 - NCT04899908RecruitingPhase 2
Brain radiation with or without gadolinium nanoparticles for brain metastases
This trial tests whether adding tiny gadolinium-containing nanoparticles to standard brain radiation can better control brain metastases from certain cancers. It is for people with tumors that have grown after immunotherapy, are from certain cancers (like melanoma, GI, or HER2+ breast), are cystic, are large, or have come back after prior radiation.
Boston, MassachusettsAges 18 years+ - NCT04919265Recruiting
Mother and baby health study from early pregnancy
This study follows pregnant people and their babies from the first few months of pregnancy through at least one year after birth. It aims to learn how health and development turn out, especially for mothers who can keep coming to the same clinic for follow-up.
Kajang, SelangorAges 18–45 - NCT04929912Recruiting
Registry for people treated with electroporation for cancer
This study is a real-world registry that collects information about people who have already received cancer treatment using electroporation methods. It may help researchers learn which treatments are used in practice and what outcomes people experience.
LondonAges Any age - NCT05111977Recruiting
Study of gut-body signals in anorexia nervosa
This trial studies how your gut and brain communicate in people with anorexia nervosa. It may help researchers understand symptoms and find better ways to measure or treat the condition.
Tulsa, OklahomaAges 15–40 - NCT05132816Recruiting
Test manometry after partial anti-reflux surgery
This study checks how well a swallowing test called high-resolution manometry works after partial anti-reflux surgery. It focuses on adults with certain abnormal esophagus muscle patterns to help doctors understand what to expect after the operation.
Schlieren, Canton of ZurichAges 18 years+ - NCT05196087Recruiting
AI system to monitor cancer treatment progress
This trial tests a non-invasive, AI-based monitoring program for people with solid tumors. It aims to help track how you’re doing during or after curative-intent treatment, using information collected without extra procedures.
Toronto, OntarioAges 18 years+ - NCT05209568Recruiting
Study of immune reactions after eating gluten
This study looks at how your immune system responds when you eat gluten, including for people with celiac disease. You may be asked to follow a gluten-free diet first and then safely reintroduce gluten so researchers can measure immune changes.
Aurora, ColoradoAges 2–101 - NCT05212129Recruiting
Stimulation of the ear nerve to help gut symptoms
This study tests whether stimulating a nerve in the ear (called auricular vagal nerve stimulation) can improve upper gut symptoms in teens who may have hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobile spectrum disorder (HSD). It also checks whether this treatment helps nerves that control the body (autonomic nervous system) and how well the gut moves.
Milwaukee, WisconsinAges 10–18 - NCT05217589Recruiting
Mood and emotions study on eating before exercise
This study looks at how different moods and emotions affect your body’s responses to eating a sports drink before you exercise. You may need to run for 30 minutes and watch/listen to video clips during the study.
Norfolk, VirginiaAges 18–55 - NCT05272579RecruitingEarly Phase 1
Phage treatment to help gut development in very preterm babies
This early-phase trial tests whether giving a specific bacteria-fighting treatment (called bacteriophage) through the gut can help preterm babies’ intestinal development mature faster. It may help reduce early gut-related problems, but the study is mainly to check safety and early effects.
CopenhagenAges Any age - NCT05274048RecruitingPhase 1
Neratinib plus antibody-drug for HER2-positive stomach or esophagus cancer
This early-phase trial tests neratinib together with an antibody-drug to treat advanced HER2-positive gastro-esophageal (stomach/esophagus) cancer that can’t be removed by surgery. It’s for people whose cancer has progressed after at least one HER2-targeted treatment, aiming to shrink tumors and improve outcomes.
Palo Alto, CaliforniaAges 18 years+ - NCT05290857Recruiting
Restarting blood thinners after a serious stomach bleed
This study follows people who had a serious, non-surgical stomach/intestine bleed while taking a blood thinner, and looks at when and how they restart a DOAC (a type of blood thinner). It may help your care team reduce the risk of another bleed while still preventing stroke or blood clots.
Calgary, AlbertaAges 18 years+
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Common questions
- Are there clinical trials for gastrointestinal?
- Yes. Clin2 currently lists 480 recruiting gastrointestinal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastrointestinal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastrointestinal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.