Clinical trials
Gastrointestinal clinical trials
Below are recruiting gastrointestinal clinical trials, each written for real people, not researchers. We’re tracking 469 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07171203RecruitingPhase 1
Imatinib and fampridine before surgery for KIT-mutant GIST
This trial tests whether combining two oral medications, imatinib and fampridine, before surgery can shrink GIST tumors that have a specific KIT gene mutation. The goal is to improve surgical outcomes and potentially reduce the risk of the tumor coming back.
La Jolla, CaliforniaAges 18 years+ - NCT07133620Recruiting
Electrical acupoint stimulation for better recovery after urologic surgery
This trial tests if using mild electrical stimulation on specific acupoints (similar to acupuncture without needles) can help your stomach and bowels get back to normal faster after laparoscopic kidney or prostate surgery.
Xiamen, FujianAges 18 years+ - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130 - NCT07124351RecruitingPhase 4
Using a special dye to see cancer during surgery
This trial tests a drug called pafolacianine (CYTALUX) that makes cancer cells glow during surgery. It may help doctors see and remove more cancer from the stomach, esophagus, or appendix. You take the drug before surgery, and a special camera shows the glowing cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT06966232RecruitingPhase 3
Using entecavir to prevent hepatitis B flare-up in gastrointestinal cancer patients
This trial tests whether giving the antiviral drug entecavir before or at the first sign of hepatitis B reactivation can prevent liver problems in gastrointestinal cancer patients who are inactive hepatitis B carriers and are starting chemotherapy or immunotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07081100Recruiting
Probiotics for stomach and bowel health improvement
This trial tests whether a probiotic supplement can help people with common stomach or bowel issues like indigestion or constipation that are not caused by another disease. You take the probiotic daily to see if it improves your symptoms.
Suzhou, JiangsuAges 18–65 - NCT07067385RecruitingPhase 1
Personalized mRNA vaccine for advanced GI cancers
This trial tests a personalized mRNA vaccine designed to teach your immune system to attack your specific tumor. It is for people with advanced gastrointestinal cancers who have exhausted other options.
Shanghai, SHAges 18 years+ - NCT07056777RecruitingPhase 1/Phase 2
DR30206 plus standard therapy for advanced GI cancer
This trial tests a new drug called DR30206 combined with standard therapy for advanced gastrointestinal cancers. It may be an option if you have colorectal, esophageal, gastric, or gastroesophageal junction cancer and have had little or no prior chemotherapy.
Guangzhou, GuangdongAges 18–75 - NCT07050485Enrolling by invitation
Postbiotic gummies after GI cancer surgery
This trial tests if taking postbiotic gummies (a type of supplement that helps good gut bacteria) can help your gut recover faster after surgery for stomach, colon, or other gastrointestinal cancers. It is for people having scheduled, minimally invasive (laparoscopic) surgery to remove their cancer.
Tampa, FloridaAges 18 years+ - NCT06954077RecruitingPhase 1
BL-M09D1 for advanced gastrointestinal and other solid tumors
This trial tests a new drug, BL-M09D1, for people with advanced or metastatic gastrointestinal or other solid tumors that have stopped responding to standard treatments. The goal is to see if the drug can shrink tumors and how safe it is.
Guangzhou, GuangdongAges 18 years+ - NCT06951490Enrolling by invitation
PillSense study for anemia and blood in stool
This trial tests a special pill that can be swallowed to help find the cause of anemia or hidden blood in the stool, without the need for more invasive tests. It is for patients who are already in the hospital and have been referred to a gastroenterologist.
Orlando, FloridaAges 18 years+ - NCT06885034RecruitingPhase 1/Phase 2
Testing a New Drug for Advanced Colon, Rectal, or Pancreatic Cancer
This study tests an experimental drug, alone or combined with other treatments, for advanced colon, rectal, or pancreatic cancer that hasn't responded to standard options or cannot be removed by surgery. The goal is to see if it is safe and if it helps shrink or slow the cancer.
Los Alamitos, CaliforniaAges 18 years+ - NCT06830304Enrolling by invitation
Boosting gastrointestinal cancer screening for high-risk adults
This study tests a new way to encourage people at high risk for gastrointestinal cancer to get screened. It compares different methods to see which works best, helping catch cancer early when it's easier to treat.
Chongqing, Chongqing MunicipalityAges 45–74 - NCT04208828Recruiting
IVIG for difficult gastrointestinal auto-immune nerve symptoms
This trial tests intravenous immunoglobulin (IVIG), a donated antibody treatment, for people whose gastrointestinal (GI) “motor” symptoms are not improving with standard care and may be auto-immune related. If you’re eligible, IVIG could help calm the immune system and improve gut movement symptoms.
Louisville, KentuckyAges 12–90 - NCT05385549RecruitingPhase 2
5-Year imatinib after GIST surgery for high-risk patients
This study looks at taking imatinib (a targeted anti-cancer pill) for 5 years after your GIST tumor has been fully removed. It is meant to lower the chance that GIST comes back in people considered “high risk.”
Seoul, SeoulAges 20 years+ - NCT06687057Recruiting
Heart rate training for anxiety and stomach issues
This study tests whether a special breathing and heart-rate training program (called HRV biofeedback) can help people who have both anxiety and a sensitive stomach or bowel (functional gastrointestinal disorder). If you often feel anxious and have belly discomfort without a clear medical cause, this training might improve both your digestion and your mood.
MilanAges 18 years+ - NCT06679478Enrolling by invitation
Early walking after stomach or bowel surgery
This study tests whether a structured early walking plan helps people recover faster after open gastrointestinal surgery. You will use a phone app to track your steps.
KütahyaAges 18–80 - NCT06680583Recruiting
Predicting recovery in cirrhosis with GI bleeding
This study looks at simple body measurements (like blood pressure and heart rate) to help predict how well people with cirrhosis (liver damage) who are having bleeding in their stomach or intestines will recover. It may help doctors make better treatment decisions.
TainanAges Any age - NCT06639126Enrolling by invitation
Thyme extract for functional gut issues
This trial tests whether a wild thyme extract can help with functional gastrointestinal disorders (common digestive problems without a clear cause). It focuses on the extract's anti-inflammatory and metabolism-related effects.
Granada, GranadaAges 18–75 - NCT06630234RecruitingPhase 1/Phase 2
Testing a new drug for advanced GIST with specific gene changes
This trial tests a new targeted therapy drug, DCC-3009, for people with advanced GIST that has a specific gene mutation (KIT or PDGFRA). It's for those who have already tried other targeted treatments and need a new option.
Scottsdate, ArizonaAges 18 years+ - NCT06560879Enrolling by invitationPhase 2
Probiotics to prevent stomach problems in children with leukemia
This trial tests whether probiotics can help prevent stomach and gut side effects from chemotherapy in children with leukemia. If your child is between 6 and 17, in the right phase of treatment, and doesn't have any major gut issues, they may be eligible.
Mexico City, CoyoacanAges 6–17 - NCT06543316Recruiting
Treating gastric bypass ulcers with low-thermal argon plasma
This study tests a new way to treat painful sores (marginal ulcers) that can happen after gastric bypass surgery. Doctors use a special tool (argon plasma) during an endoscopy to help the sores heal faster, and you will get standard ulcer medicine too.
Boston, MassachusettsAges 18 years+ - NCT06532877Recruiting
Telephone support for advanced GI cancer and caregivers
This study offers telephone-based support for people with advanced gastrointestinal cancer who are experiencing fatigue, and for their family caregivers. It aims to help both you and your caregiver manage the challenges of cancer care together.
Chicago, IllinoisAges 18 years+ - NCT06529159Recruiting
Treating H. pylori with argon plasma during endoscopy
This trial tests a new way to treat H. pylori infection using argon plasma (a kind of energy) during an upper endoscopy. It may help people who haven't yet taken antibiotics for H. pylori and are already having an endoscopy.
Boston, MassachusettsAges 18 years+
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Common questions
- Are there clinical trials for gastrointestinal?
- Yes. Clin2 currently lists 469 recruiting gastrointestinal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a gastrointestinal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a gastrointestinal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.