Clinical trials
Head Cancer clinical trials
Below are recruiting head cancer clinical trials, each written for real people, not researchers. We’re tracking 522 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04593589RecruitingPhase 1
Stem cell transplant to protect salivary function after oral cancer
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
GroningenAges 18 years+ - NCT04632654Recruiting
Video game exercise program to help head and neck cancer symptoms
This study tests a “motion-based video game” type exercise to help with moderate fatigue and/or pain in adults with head and neck cancer. It may help you feel better day to day while staying active at a low-to-moderate intensity.
Birmingham, AlabamaAges 18 years+ - NCT05082961Recruiting
Blood immune markers and brain radiation after head/neck surgery
This study looks at immune system signals in your blood during and after postoperative radiation therapy for certain head and neck cancers involving the brain or skull base. Researchers want to see whether these “immune markers” relate to treatment response or side effects.
CaenAges 18 years+ - NCT05319483Recruiting
Study of new head and neck cancer patients
This study enrolls adults with a first-time head and neck cancer diagnosis and collects health and treatment information to better understand the disease. It may help clinicians improve care by learning which treatments and patient features matter most.
Pécs, BaranyaAges Any age - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+ - NCT05539638Recruiting
Testing blood DNA for head and neck squamous cancer
This study looks at how tumor DNA found in a blood sample (a “DNA signal”) relates to head and neck cancer in the oropharynx. It may help doctors understand disease status and improve how they monitor treatment, for both HPV-positive and HPV-negative cancers.
Dundee, DD2 1SGAges 18 years+ - NCT05621889RecruitingPhase 1/Phase 2
Virtual speech therapy program for head and neck cancer patients
This trial tests a partner-guided virtual speech therapy program delivered through group sessions and questionnaires for people with head and neck cancer. If you’re starting curative chemo-radiation, the program may help with speech and swallowing-related symptoms during treatment.
Montreal, QuebecAges 18 years+ - NCT05853692Recruiting
Preventing mouth sores during head and neck radiation
This trial tests a gel called “Gel X” to help prevent painful mouth sores (oral mucositis) in people receiving radiation for head and neck cancer. It may help you stay more comfortable and maintain eating and speaking during treatment.
Roma, ItalyAges 18 years+ - NCT06127784Recruiting
Survivorship program for head and neck cancer follow-up
This trial tests a new program to help people who finished treatment for head and neck cancer stay on track with follow-up care. You may be able to join if you completed treatment 3 to 6 months ago and your cancer has not spread.
London, OntarioAges 18 years+ - NCT06307314Recruiting
Can SAA1 predict mouth sores from radiation therapy?
This study is looking at a blood marker called SAA1 to see if it can predict how severe mouth sores (oral mucositis) will be after radiation therapy. If you have head and neck cancer and are about to get radiation, this trial may help answer questions about side effects.
Guangzhou, GuangdongAges 18 years+ - NCT06307327Recruiting
Comparing new and old ways to classify mouth sores from radiation
This study compares a new way of classifying radiation-induced mouth sores (mucositis) with the traditional method. It aims to better understand and manage these painful sores in people receiving radiation for head and neck cancer.
Guangzhou, GuangdongAges 18 years+ - NCT06353685RecruitingPhase 2
Less radiation after surgery for oral cancer with good response
This trial is testing whether giving less radiation after surgery is safe and effective for people with oral cancer whose surgery results were very good (no cancer cells or very few left). It aims to reduce side effects while still preventing cancer from coming back.
GuangzhouAges 18–80 - NCT06354712RecruitingPhase 2
Can N-acetylcysteine prevent mouth sores during radiation?
This study tests whether a medicine called N-acetylcysteine (NAC) can prevent mouth sores caused by radiation therapy for head and neck cancer. If you are starting radiation, this trial may help protect your mouth from painful side effects.
Al MansurahAges 18–80 - NCT06468852Recruiting
Fluid management during head and neck cancer surgery
This trial tests whether a specific way of giving fluids during surgery (called goal-directed fluid therapy) can improve recovery after head and neck cancer surgery. It involves having a small tube in your artery to closely watch your blood pressure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06477692RecruitingPhase 2
Comparing Neck Radiation Options for Head and Neck Cancer
This trial is testing whether radiation to just the lymph nodes near the tumor is as effective as treating a larger area of the neck. It is for people with certain head and neck cancers (not unknown primary or glottic) and aims to lower side effects.
Dallas, TexasAges 18–99 - NCT06531083Recruiting
Early monitoring and physical therapy to prevent jaw stiffness after radiation
This study tests whether a program of early monitoring and physical therapy can help prevent or reduce jaw stiffness (trismus) after radiation therapy for head and neck cancer. It is for patients who are about to start radiation and want to keep their jaw working well.
Edmonton, AlbertaAges 18 years+ - NCT06549946RecruitingPhase 1/Phase 2
Ixovex-1 injection alone or with another drug for advanced solid tumors
This trial tests an experimental injection called Ixovex-1, either alone or with another drug (pembrolizumab), for people with advanced solid tumors that can be injected. It is for those who have run out of standard options and have tumors that are not too deep inside the body.
LondonAges 18 years+ - NCT06579248RecruitingEarly Phase 1
Cooling device to protect taste during radiation
This trial tests a special mouthpiece that cools the tongue during radiation therapy for advanced larynx cancer. It may help prevent taste loss caused by treatment.
Detroit, MichiganAges 18 years+ - NCT06771336Recruiting
Study of standard care for jawbone reconstruction after cancer
This trial studies current standard care for people who need jawbone reconstruction after cancer surgery. It aims to document the costs and outcomes of using a piece of bone from another part of the body (a free bone flap) to rebuild the face.
AmiensAges 18 years+ - NCT06781567RecruitingPhase 2
HG146 for advanced adenoid cystic carcinoma
This trial tests a new drug called HG146 for people with advanced adenoid cystic carcinoma that has progressed despite previous treatments. The goal is to see if HG146 can slow or stop the cancer from growing.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06943820RecruitingPhase 1/Phase 2
AK129 combination therapy for advanced solid tumors
This trial tests a new combination of drugs (including AK129) for people with advanced solid tumors, specifically lung cancer, head and neck cancer, or colorectal cancer. It is for those who have already tried a platinum chemo and a PD-1/PD-L1 drug but their cancer got worse.
Shenyang, LiaoningAges 18–75 - NCT07021885Recruiting
Nutrition literacy and outcomes in head and neck cancer survivors and caregivers
This study looks at how nutrition literacy (understanding food and diet) affects health outcomes for head and neck cancer survivors and their caregivers. If you are a survivor who finished treatment 6 months to 4 years ago and can eat by mouth, you and your caregiver may be able to join.
Kansas City, KansasAges 18 years+ - NCT07027280Recruiting
Measuring Tumor Differences in Head and Neck Cancer
This study uses scans and tissue samples to look at differences within your tumor (called heterogeneity). It may help doctors understand your cancer better and choose the best treatment approach.
ChongqingAges 15–89 - NCT07064577Recruiting
New cream for radiation skin damage in head and neck cancer
This trial tests a new type of cream made with tiny particles that mop up harmful molecules to prevent or treat skin damage from radiation. It is for people with head or neck cancer receiving high-dose radiation to see if it can reduce skin redness, pain, and peeling.
Chengdu, SichuanAges 18–80
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Common questions
- Are there clinical trials for head cancer?
- Yes. Clin2 currently lists 522 recruiting head cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Cancer
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Non Small Cell Lung Cancer
- Head and Neck Squamous Cell Cancer
- Head and Neck Cancer (H&N)
- Head and Neck Cancer Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Gastric Cancer, Gastroesophageal Junction Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.