Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07136740Recruiting
Biofeedback for preventing tension headaches
This study tests whether a smartphone app that teaches you biofeedback (a way to relax muscles using sensors) can help prevent tension headaches. You will use the app at home to practice techniques and track your headaches.
NamsosAges 18 years+ - NCT07059546Recruiting
Studying sensitivity to adrenomedullin in chronic post-traumatic headache
This trial tests whether people with long-term headache after a mild head injury have an abnormal reaction to a substance called adrenomedullin, which may play a role in causing headaches. You will receive adrenomedullin and a placebo in separate sessions to see how your headache responds.
Glostrup MunicipalityAges 18–65 - NCT07022496RecruitingPhase 4
Can oral caffeine help with acute migraine attacks?
This trial tests whether taking caffeine by mouth can reduce the severity of a migraine attack when it happens. It may offer a simple, at-home option for people with different types of migraine.
CairoAges 18–60 - NCT05620719Recruiting
Study delayed headache after head injury in veterans
This study looks at treatment for ongoing headache that starts or gets worse after a mild or moderate head/neck injury in veterans or active-duty service members. It may help by testing an approach aimed at reducing headache burden and improving daily functioning.
Los Angeles, CaliforniaAges 18–70 - NCT06134791Recruiting
Comparing neck test results in cervicogenic headache patients
This study compares people with cervicogenic headache (headache from neck problems) to see if a simple neck test can tell them apart. It aims to help doctors diagnose this type of headache better.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06253754Recruiting
Study of headache after spinal tap
This trial looks at why some people get a headache after a spinal tap and how treatment might help. It may be an option if you are between 20 and 40 and have this kind of headache.
Umeå, Västerbotten CountyAges 20–40 - NCT07872943RecruitingPhase 4
Chinese herbal tablets for frequent tension-type headache
This study tests whether a Chinese herbal tablet called Zhixuan Analgesic can reduce headache frequency in adults with frequent tension-type headaches. Participants will take the tablets for a period and track their headache days.
Wuhan, HubeiAges 18–60 - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT07820280Recruiting
Neck mobilization for cervicogenic headache relief
This study compares two gentle neck therapy techniques to see which better reduces headaches that start from the neck. It aims to help people with neck-related headaches move better and feel less pain.
IslamabadAges 18–40 - NCT07812740Recruiting
A long-term study of rare headache disorders
This study is designed to learn more about a group of rare headache disorders called trigeminal autonomic cephalalgias (TACs). If you have one of these conditions, participating could help doctors better understand how they behave over time and improve care for others like you.
Milan, MIAges 18 years+ - NCT07796074RecruitingPhase 2
Nerve block injection for veterans with headache after head injury
This trial tests a nerve block injection to see if it can reduce headaches in veterans who have had a head injury and continue to have headaches for at least three months. It may offer a new way to help manage persistent post-injury headaches.
West Haven, ConnecticutAges 18 years+ - NCT07776275Recruiting
Headache study comparing neck pain patients with healthy people
This study looks at physical differences between people with cervicogenic headache (a headache that starts in the neck), people with chronic neck pain without headache, and healthy controls. By comparing these groups, researchers hope to better understand what causes the headache and which physical features are specific to it.
Istanbul, SefaköyAges 25–60 - NCT07706751Recruiting
Predicting headache after spinal anesthesia during C-section
This study looks at whether certain factors can predict headaches that sometimes happen after getting spinal anesthesia for a planned C-section. The goal is to help doctors identify women at higher risk so they can offer better care.
AmasyaAges 18–45 - NCT07698249Enrolling by invitation
Headache diary for migraine patients
This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.
Edison, New JerseyAges 18 years+ - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT07677137Recruiting
Study of a new nerve stimulation device for chronic cluster headache prevention
This study is testing a new device that uses mild electrical stimulation near the back of the head to prevent cluster headaches. It is for people with chronic cluster headaches that are hard to treat with standard medicines.
Sint-NiklaasAges 22–70 - NCT07661758RecruitingPhase 3
Lidocaine to prevent headache after C-section
This trial tests if giving lidocaine through an IV can prevent the headache that sometimes happens after spinal anesthesia during a planned C-section. If you are having a planned C-section with spinal anesthesia and meet other health requirements, this study might help reduce your risk of post-procedure headache.
Tanta, Gharbia GovernorateAges 18 years+ - NCT03944876RecruitingPhase 3
Botulinum toxin to block a facial nerve for chronic cluster headaches
This trial tests whether injections of botulinum toxin type A can reduce frequent, severe cluster headache attacks by targeting a facial nerve area. It’s for people whose cluster headaches have not responded well—or have caused side effects—to standard preventive treatments.
HamburgAges 18–85 - NCT07568496Recruiting
Nerve block for migraine with medication overuse headache
This study tests a nerve block injection at the back of the head to see if it can reduce migraines in people who also have headaches from overusing pain medication. It aims to provide a new treatment option for this difficult-to-treat condition.
Bangkok, BangkokAges 18–80 - NCT06731114Recruiting
Neck muscle release for cervicogenic headache relief
This trial tests whether releasing the sternocleidomastoid neck muscle on top of the usual suboccipital muscle release helps reduce headaches that start from the neck. If you have headaches with neck stiffness and pain rating of 4 or more, this study may help find a more effective treatment.
Rawalpindi, Punjab ProvinceAges 18–45 - NCT07553533Enrolling by invitation
Temporary Nerve Stimulation for Headache Relief
This trial studies a temporary nerve-stimulation device placed near the back of your head to treat chronic headaches. The device sends mild electrical pulses to help reduce headache pain over 60 days, and your doctor has already decided this treatment is right for you as part of your regular care.
New Haven, ConnecticutAges 18 years+ - NCT07508410Recruiting
Mulligan vs Myofascial Release for Neck-Related Headaches
This study compares two hands-on therapy techniques—Mulligan mobilization and myofascial release—to see which works better for headaches that start from the neck. If you have neck pain on one side and headaches that get worse with movement, this trial may help you find relief.
KonyaAges 18–65 - NCT07515456Recruiting
Comparing Three Medications for Spinal Headaches
This study tests three different medications—theophylline, sumatriptan, and gabapentin—to see which works best for headaches that occur after a spinal procedure. You would receive one of these treatments and be monitored to see how well it relieves your pain.
Tanta, El-GharbiaAges 21–50 - NCT07477236Recruiting
Sleep and headache management study
This study tests a natural supplement to help adults manage everyday headaches and improve sleep. You will take the supplement daily and fill out weekly surveys and a daily log.
New York, New YorkAges Any age
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 164 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.