Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07487649Recruiting
Treatment response in headache from medication overuse
This trial looks at how well people respond to treatment when their headaches are caused by taking too much pain medicine. It may help if you have migraines or tension headaches and you use triptans or NSAIDs often.
EdirneAges 18–65 - NCT05229224Recruiting
Study of a new device for frequent tension headaches
This pilot study tests a device approach (“Osteo-Fluidic-Sensitive”) for people who get frequent episodic tension-type headaches. It aims to see whether the device is safe and can reduce headache burden for the right kind of headache pattern.
PoitiersAges 18–75 - NCT07706751Recruiting
Predicting headache after spinal anesthesia during C-section
This study looks at whether certain factors can predict headaches that sometimes happen after getting spinal anesthesia for a planned C-section. The goal is to help doctors identify women at higher risk so they can offer better care.
AmasyaAges 18–45 - NCT07297901Enrolling by invitation
Breathing app study for migraine relief
This trial tests a smartphone-based breathing program to help reduce migraines. It uses heart rate data to guide breathing exercises tailored to you.
Phoenix, ArizonaAges 18 years+ - NCT07698249Enrolling by invitation
Headache diary for migraine patients
This trial tests whether a headache diary can help people with migraine track their symptoms and improve their care.
Edison, New JerseyAges 18 years+ - NCT07113470Recruiting
Nerve stimulation for chronic cluster headache prevention
This trial tests if a device that stimulates nerves on your face and the back of your head can prevent chronic cluster headaches. It may offer a new treatment option if you have had cluster headaches for at least a year.
LeidenAges 18 years+ - NCT03231241Recruiting
Study of worsening headaches using scans and blood testing
This study looks at why headaches can become long-lasting (“chronified”) by combining answers from online questionnaires, brain imaging, and blood protein tests. Your participation may help researchers find biological clues that could improve how headache problems are understood and treated.
Stanford, CaliforniaAges 18 years+ - NCT03781128RecruitingPhase 2
LSD for cluster headaches in a clinical study
This Phase 2 study tests whether a supervised dose of LSD (or a placebo) can reduce cluster headache attacks. It’s for people whose cluster headaches respond to oxygen, and who can safely pause certain medications and substances around the dosing day.
BaselAges 25–75 - NCT03944876RecruitingPhase 3
Botulinum toxin to block a facial nerve for chronic cluster headaches
This trial tests whether injections of botulinum toxin type A can reduce frequent, severe cluster headache attacks by targeting a facial nerve area. It’s for people whose cluster headaches have not responded well—or have caused side effects—to standard preventive treatments.
HamburgAges 18–85 - NCT04609709Recruiting
Physical therapy plus electrical dry needling for tension headaches
This trial tests whether specific physical therapy treatments—exercise, manual soft-tissue work, mobilization, and electrical dry needling/TENS—can reduce tension-type headaches. It may help if your headaches happen often and fit the trial’s “frequent” or “chronic” pattern.
Fort Wayne, IndianaAges 18–65 - NCT04685772Recruiting
Medrol Dose Pack for new concussion headache relief
This trial tests whether a Medrol “dose pack” (a short course of steroid medicine taken by mouth) can reduce acute headache pain after a concussion. It may help people whose concussion headaches are frequent and severe soon after injury.
Manhasset, New YorkAges 18 years+ - NCT05116930RecruitingPhase 2
Medicine for headache after a labor spinal needle
This Phase 2 study tests neostigmine plus glycopyrrolate to treat a specific type of severe headache that happens after a dural puncture during labor. If you have a new headache starting within 72 hours of delivery and no other cause, this treatment may help relieve your pain.
Rochester, MinnesotaAges 18–54 - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT05415020Recruiting
Behavior program for chronic migraine
This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.
Phoenix, ArizonaAges 18 years+ - NCT05477459RecruitingPhase 2
LSD treatment for reducing the burden of cluster headaches
This Phase 2 trial tests LSD to see if it can reduce how much cluster headaches disrupt your life. You may be eligible if your cluster headaches are frequent and steady, and if you meet key safety and mental-health requirements.
LeidenAges 16–75 - NCT05804448Recruiting
Altitude effect on spinal headache after C-section
This study looks at whether living at higher or lower altitudes changes the risk of a specific headache after a C-section done with spinal anesthesia. The goal is to understand who is more likely to get this headache so care can be better tailored.
Jumla, KarnaliAges 18 years+ - NCT06015451Recruiting
Exercise for concussion symptoms and headache
This trial tests whether a carefully supervised exercise program can help people who still have headaches or other symptoms weeks after a mild head injury. If you get symptoms when you try to be active, this study may offer a structured way to help you recover.
TrondheimAges 18–65 - NCT06041997Recruiting
Limiting smartphone use for headache relief
This trial tests whether reducing smartphone use can help treat primary headaches (migraines or tension headaches) in adults. If you get headaches that aren't caused by another medical condition, this study might be a good fit.
New Delhi, National Capital Territory of DelhiAges 18 years+ - NCT06062446Recruiting
A new way to do lumbar puncture to prevent headaches
This study tests a modified lumbar puncture (spinal tap) procedure to reduce the chance of getting a headache afterward. It's for people who need a spinal tap as part of their regular medical care.
Houston, TexasAges 18 years+ - NCT06069791RecruitingPhase 1
Nerve block study for veterans with post-concussion headaches
This study tests a nerve block injection (a numbing medicine) in the back of the head to see if it helps veterans with long-term headaches after a concussion. You might join if you have had frequent headaches for at least three months after a head injury.
West Haven, ConnecticutAges 18 years+ - NCT06077747Recruiting
Lumbar vein treatment for chronic headaches with nutcracker anatomy
This study tests a procedure called lumbar vein embolization to treat daily headaches that feel like pressure and get worse when lying down. It's for people who have a rare anatomy where a vein in the kidney is pinched (nutcracker physiology), and standard headache medicines haven't helped.
Jacksonville, FloridaAges 18 years+ - NCT06112093RecruitingPhase 1
Magnetic brain stimulation for headaches after a concussion
This study tests whether a non-invasive magnetic pulse treatment (repetitive transcranial magnetic stimulation) can help people with long-lasting headaches following a mild concussion. If you are 18 to 55 years old and have had daily headaches for at least 3 months after your head injury, this study may help find a new way to relieve your pain.
Syracuse, New YorkAges 18–55 - NCT06134791Recruiting
Comparing neck test results in cervicogenic headache patients
This study compares people with cervicogenic headache (headache from neck problems) to see if a simple neck test can tell them apart. It aims to help doctors diagnose this type of headache better.
Ghent, Oost-VlaanderenAges 18 years+ - NCT06203873Recruiting
Comparing biodegradable vs. metal heart-hole closures for migraine
This trial compares two types of devices (biodegradable vs. metal) to close a small hole in the heart (PFO) in people who have migraine not controlled by usual treatments. It aims to see which device works better to reduce migraine attacks.
Beijing, Beijing MunicipalityAges 18–65
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 165 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.