Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06253754Recruiting
Study of headache after spinal tap
This trial looks at why some people get a headache after a spinal tap and how treatment might help. It may be an option if you are between 20 and 40 and have this kind of headache.
Umeå, Västerbotten CountyAges 20–40 - NCT06398353Recruiting
Acupuncture for frequent primary headaches
This study tests whether acupuncture can improve quality of life for people with frequent primary headaches (like migraines or tension headaches). If you have headaches more than twice a week, this trial may help you find relief.
Taoyuan, Select A StateAges 18 years+ - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65 - NCT06503328Recruiting
Cluster headache microRNA study
This study aims to understand how certain tiny molecules in the blood (called microRNAs) are different in people with cluster headache. It could help find better ways to diagnose or treat this condition.
PaviaAges 18–65 - NCT06540651Recruiting
Light therapy for chronic cluster headache
This study tests whether daily light therapy can reduce the number of cluster headache attacks in people with chronic cluster headache. It is a non-drug treatment that uses a special lamp to see if it helps calm your headache cycles.
MarseilleAges 18 years+ - NCT06582810Recruiting
Lidocaine for headaches after brain bleed
This study tests whether a lidocaine infusion (given through an IV) can safely reduce severe headaches after a subarachnoid hemorrhage (a type of brain bleed). You may qualify if you had a spontaneous bleed and can communicate your pain level.
Wichita, KansasAges 18 years+ - NCT06608277RecruitingPhase 2
Ketamine and nerve block for headache or PTSD after brain injury
This study tests if ketamine infusions or a stellate ganglion block (a numbing injection near the neck) can help people with long-term headaches or PTSD after a traumatic brain injury. It compares these treatments alone and together.
Chicago, IllinoisAges 18 years+ - NCT06621329RecruitingPhase 2/Phase 3
Numbing shot for headache after brain bleed
This trial tests a numbing injection inside the nose to quickly relieve severe headaches caused by a brain bleed (subarachnoid hemorrhage). It may help reduce pain without strong medicines.
Sacramento, CaliforniaAges 18–100 - NCT06631222Recruiting
Can cognitive behavioral therapy help smartphone addiction and tension headaches?
This trial tests if cognitive behavioral therapy (a type of talk therapy that changes unhelpful thoughts and behaviors) can reduce both smartphone addiction and tension-type headaches. It is for people aged 19-34 who have frequent tension headaches and are heavy smartphone users.
Cairo, Cairo GovernorateAges 19–34 - NCT06652724Recruiting
Psychological help for chronic pain in fibromyalgia and migraine
This study looks at how psychological factors and treatments might help with chronic pain in people with fibromyalgia and/or chronic migraine. It compares different groups to understand what works best.
Rome, RMAges 18–50 - NCT06008795RecruitingPhase 2
Pain-block injection for headache after brain bleed
This study tests a pain-block injection (called a PPF-block) for severe headaches after a brain bleed (subarachnoid hemorrhage). It compares the injection to standard pain medicine to see if it reduces headache and the need for opioids.
Gainesville, FloridaAges 18–85 - NCT07661758RecruitingPhase 3
Lidocaine to prevent headache after C-section
This trial tests if giving lidocaine through an IV can prevent the headache that sometimes happens after spinal anesthesia during a planned C-section. If you are having a planned C-section with spinal anesthesia and meet other health requirements, this study might help reduce your risk of post-procedure headache.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06731114Recruiting
Neck muscle release for cervicogenic headache relief
This trial tests whether releasing the sternocleidomastoid neck muscle on top of the usual suboccipital muscle release helps reduce headaches that start from the neck. If you have headaches with neck stiffness and pain rating of 4 or more, this study may help find a more effective treatment.
Rawalpindi, Punjab ProvinceAges 18–45 - NCT06745648Recruiting
Head massage in a head-down position for headache relief
This trial tests a simple, non-drug technique (carotid sinus massage while lying with your head lower than your body) to see if it can relieve headaches. If you have a migraine, tension headache, or mixed headache that started in the last day, you may be able to join.
Trenque Lauquen, Buenos AiresAges 16 years+ - NCT06787677Recruiting
SPG pulsed radiofrequency for chronic cluster headache
This trial tests a treatment called sphenopalatine ganglion (SPG) pulsed radiofrequency for people with chronic cluster headache. It uses short bursts of energy to calm a nerve cluster in the face that is linked to the pain, and may help when standard medicines like verapamil or lithium haven't worked.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06802471Recruiting
Can electroacupuncture help medication overuse headache?
This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can help people who have headaches very often because they use pain relievers too much. If you join, you will receive either real or sham (placebo) electroacupuncture, and your headaches and quality of life will be tracked for several months.
Beijing, Beijing MunicipalityAges 18–80 - NCT06824025RecruitingEarly Phase 1
Comparing two drugs for headache after spinal anesthesia in C-section
This trial tests if a combination of neostigmine and atropine works better than lidocaine for treating severe headaches that can happen after spinal anesthesia during a planned C-section. It aims to find a more effective way to relieve this type of headache.
MinyaAges 18–35 - NCT06875869Recruiting
Pressure techniques for cervicogenic headache
This trial compares two different pressure techniques (ischemic compression and the Jones technique) to see which better relieves head pain that starts from the neck (cervicogenic headache). It may help if you are an adult aged 25 to 35 with neck-related headaches and specific tender points in your muscles.
Bahawalpur, Punjab ProvinceAges 25–35 - NCT07006454Recruiting
Neck glide techniques for headache from neck problem
This trial tests two different gentle hand-on-neck techniques to see which works better for headaches caused by a neck problem. It may help if your headache is linked to neck stiffness or injury.
IslamabadAges 18–44 - NCT07071506Recruiting
New tools to track migraine prevention
This study tests new ways to monitor how well preventive migraine treatments are working. It is for people with chronic migraine who may be starting or already using preventive medications.
Aarhus C, DenmarkAges 18–65 - NCT07075874Recruiting
Blood test ratio and headache after C-section spinal
This study looks at whether a simple blood test result (the ratio of two types of white blood cells) can help predict and understand a common headache after spinal anesthesia during C-section. If you qualify, your existing medical records will be reviewed—no extra visits or procedures needed.
Istanbul, Merkez MahallesiAges 18 years+ - NCT07116408RecruitingPhase 4
Numbing spray for headaches after brain bleed
This study tests if a numbing spray applied inside the nose can help reduce headaches in people who have had a brain bleed from a ruptured aneurysm. The treatment targets a nerve cluster linked to headache pain.
Dayton, OhioAges 18 years+ - NCT07163208Recruiting
Laser therapy for headache from neck problems
This trial tests if different types of low-level laser light can help reduce headaches caused by neck issues. It is a non-invasive treatment option for people whose headaches have lasted at least three months.
Lahore, Punjab ProvinceAges 18–65 - NCT07054801RecruitingPhase 2
Testing lidocaine and steroids for headache after bleeding stroke
This study tests whether giving two medicines (lidocaine and methylprednisolone) directly into the artery during a routine brain vessel procedure can help relieve headaches caused by a bleeding stroke. It may help find a new treatment for this type of headache.
San Francisco, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 165 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.