Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07479082Recruiting
Ear nerve stimulation for headache after aneurysm coiling
This trial tests whether a gentle electrical device placed on your ear (called transcutaneous auricular vagus nerve stimulation) can help prevent or reduce headaches that sometimes happen after a procedure to treat an unruptured brain aneurysm. If you're scheduled for stent-assisted coiling or flow diverter treatment, this study may offer a non-drug option to manage post-surgery pain.
Beijing, Beijing MunicipalityAges 18–80 - NCT07477483Recruiting
Manual therapy for tension headaches in menopausal women
This study tests if manual therapy (gentle hands-on techniques) can help reduce tension-type headaches in women going through menopause or premenopause. It involves tracking your headache symptoms and receiving treatment over several sessions.
Konya, KonyaAges 45–65 - NCT06787677Recruiting
SPG pulsed radiofrequency for chronic cluster headache
This trial tests a treatment called sphenopalatine ganglion (SPG) pulsed radiofrequency for people with chronic cluster headache. It uses short bursts of energy to calm a nerve cluster in the face that is linked to the pain, and may help when standard medicines like verapamil or lithium haven't worked.
Beijing, Beijing MunicipalityAges 18 years+ - NCT03781128RecruitingPhase 2
LSD for cluster headaches in a clinical study
This Phase 2 study tests whether a supervised dose of LSD (or a placebo) can reduce cluster headache attacks. It’s for people whose cluster headaches respond to oxygen, and who can safely pause certain medications and substances around the dosing day.
BaselAges 25–75 - NCT07373275Enrolling by invitation
Lifestyle Medicine for Teen Migraine
This study tests whether a lifestyle medicine program (like healthy habits and stress management) can help reduce migraine headaches in teenagers. It's for teens who get frequent migraines and are patients at certain MaineHealth clinics.
Scarborough, MaineAges 14–18 - NCT07366060Recruiting
Neck nerve treatment for headache from the neck
This study tests a procedure called pulsed radiofrequency on a nerve in your neck to see if it helps headaches that start from the neck. If standard treatments haven't worked for you, this might be an option.
Ankara, AnkaraAges 18 years+ - NCT07360782Recruiting
Personalized nerve treatment for medication overuse headache
This trial tests a treatment called personalized pulsed radiofrequency, which uses gentle electrical pulses on a nerve at the back of your head to help reduce headaches caused by using too much pain medication. It is designed for people who have been diagnosed with Medication Overuse Headache and want a non-drug option.
AnkaraAges 18–65 - NCT07354464RecruitingPhase 3
Treating spinal headache: nose spray vs. blood patch
This trial compares two treatments for the severe headache that can occur after a spinal tap or epidural. One treatment is a numbing medicine sprayed into the nose (sphenopalatine block), the other is a blood patch (injecting your own blood into your back). The goal is to see which works better and faster.
Clermont-FerrandAges 18 years+ - NCT07361549RecruitingPhase 2
Lidocaine injection for chronic migraine pain
This study tests if injecting lidocaine (a numbing medicine) into an artery in the head can reduce chronic migraine pain. It may help people who have frequent migraines and are already getting a brain imaging test.
Camden, New JerseyAges 18 years+ - NCT07347730Recruiting
Trigger point injections for chronic headache from the neck
This study tests whether injections into muscle trigger points can reduce chronic headache pain that starts in the neck. It may help people who have not found relief from standard pain medications.
Beijing, Beijing MunicipalityAges 18–65 - NCT07325513Recruiting
Brain stimulation for Gulf War-related pain
This study tests whether a type of brain stimulation (repeated transcranial magnetic stimulation, or rTMS) can help reduce headaches and body pain in veterans with Gulf War Illness. If you are a Gulf War veteran with ongoing moderate-to-severe pain, this trial could help find a new way to manage your symptoms.
San Diego, CaliforniaAges 18–65 - NCT07307508Recruiting
Scalp block for headache after aneurysm bleeding
This trial tests if a scalp nerve block can better manage severe headaches after a brain aneurysm rupture. It is for patients who had an aneurysm treated with coiling in the intensive care unit.
DohaAges 18 years+ - NCT07310823Enrolling by invitation
Manual therapy for neck-related headaches
This study tests if manual therapy (hands-on treatment) can help people whose headaches start from neck problems. If you have headaches at least once a week and limited neck movement, this trial may be an option.
GizaAges 20–40 - NCT06875869Recruiting
Pressure techniques for cervicogenic headache
This trial compares two different pressure techniques (ischemic compression and the Jones technique) to see which better relieves head pain that starts from the neck (cervicogenic headache). It may help if you are an adult aged 25 to 35 with neck-related headaches and specific tender points in your muscles.
Bahawalpur, Punjab ProvinceAges 25–35 - NCT07297901Enrolling by invitation
Breathing app study for migraine relief
This trial tests a smartphone-based breathing program to help reduce migraines. It uses heart rate data to guide breathing exercises tailored to you.
Phoenix, ArizonaAges 18 years+ - NCT06540651Recruiting
Light therapy for chronic cluster headache
This study tests whether daily light therapy can reduce the number of cluster headache attacks in people with chronic cluster headache. It is a non-drug treatment that uses a special lamp to see if it helps calm your headache cycles.
MarseilleAges 18 years+ - NCT07295587Enrolling by invitation
Headache impact study for Libbs employees
This trial looks at how headaches affect employees at Libbs Pharmaceutical. It uses health data from the Dr. Cefaleia app to understand the burden of headaches at work.
São Paulo, São PauloAges Any age - NCT07269561Recruiting
Headache registry and long-term follow-up study
This trial is a registry study that tracks people with various headache disorders over time. It aims to learn more about how headaches affect patients and to improve future care.
Wuhan, HubeiAges 6–70 - NCT05477459RecruitingPhase 2
LSD treatment for reducing the burden of cluster headaches
This Phase 2 trial tests LSD to see if it can reduce how much cluster headaches disrupt your life. You may be eligible if your cluster headaches are frequent and steady, and if you meet key safety and mental-health requirements.
LeidenAges 16–75 - NCT07168512Recruiting
Release technique and exercises for cervicogenic headache
This trial tests whether a gentle hands-on therapy called myofascial release, alone or with exercises, can improve the neck curve, sleep, and mood in people whose headaches come from a neck problem. If you have headaches that start from your neck, this might help you find relief.
Gaza, Gaza StripAges 20–55 - NCT07163208Recruiting
Laser therapy for headache from neck problems
This trial tests if different types of low-level laser light can help reduce headaches caused by neck issues. It is a non-invasive treatment option for people whose headaches have lasted at least three months.
Lahore, Punjab ProvinceAges 18–65 - NCT07116408RecruitingPhase 4
Numbing spray for headaches after brain bleed
This study tests if a numbing spray applied inside the nose can help reduce headaches in people who have had a brain bleed from a ruptured aneurysm. The treatment targets a nerve cluster linked to headache pain.
Dayton, OhioAges 18 years+ - NCT06502951Recruiting
Treatment for headache and neck pain after whiplash
This study tests if combining spinal manipulation and dry needling can reduce headache and neck pain in people who have had whiplash from a car accident. It may help if you've had symptoms for more than 4 weeks.
Montgomery, AlabamaAges 18–65 - NCT07113470Recruiting
Nerve stimulation for chronic cluster headache prevention
This trial tests if a device that stimulates nerves on your face and the back of your head can prevent chronic cluster headaches. It may offer a new treatment option if you have had cluster headaches for at least a year.
LeidenAges 18 years+
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 164 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.