Clinical trials
Headache clinical trials
Below are recruiting headache clinical trials, each written for real people, not researchers. We’re tracking 164 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05804448Recruiting
Altitude effect on spinal headache after C-section
This study looks at whether living at higher or lower altitudes changes the risk of a specific headache after a C-section done with spinal anesthesia. The goal is to understand who is more likely to get this headache so care can be better tailored.
Jumla, KarnaliAges 18 years+ - NCT05415020Recruiting
Behavior program for chronic migraine
This trial tests a behavioral (talk/skills-based) program to help people with chronic migraine. It may help reduce migraine frequency or improve day-to-day coping.
Phoenix, ArizonaAges 18 years+ - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT05229224Recruiting
Study of a new device for frequent tension headaches
This pilot study tests a device approach (“Osteo-Fluidic-Sensitive”) for people who get frequent episodic tension-type headaches. It aims to see whether the device is safe and can reduce headache burden for the right kind of headache pattern.
PoitiersAges 18–75 - NCT05116930RecruitingPhase 2
Medicine for headache after a labor spinal needle
This Phase 2 study tests neostigmine plus glycopyrrolate to treat a specific type of severe headache that happens after a dural puncture during labor. If you have a new headache starting within 72 hours of delivery and no other cause, this treatment may help relieve your pain.
Rochester, MinnesotaAges 18–54 - NCT04685772Recruiting
Medrol Dose Pack for new concussion headache relief
This trial tests whether a Medrol “dose pack” (a short course of steroid medicine taken by mouth) can reduce acute headache pain after a concussion. It may help people whose concussion headaches are frequent and severe soon after injury.
Manhasset, New YorkAges 18 years+ - NCT03511846Enrolling by invitationPhase 1
Pain biomarker study for headache or back nerve pain
This study looks at measurable “pain signals” (biomarkers) in people with certain headache disorders or lumbar nerve pain, and compares them with healthy people. It may help researchers better understand what drives pain and how it can be detected.
Houston, TexasAges 18 years+ - NCT04032379Recruiting
Study biomarkers to predict outcomes in idiopathic intracranial hypertension
This study looks at body measurements (“biomarkers”) to help doctors diagnose idiopathic intracranial hypertension (IIH) and predict how it may go over time. If you’re an adult with a doctor’s concern for IIH, you may be asked to provide health information and possibly samples for testing.
Copenhagen, GlostrupAges 18 years+ - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT05325580RecruitingPhase 3
IV magnesium vs placebo for sudden non-injury headaches
This trial tests whether giving magnesium sulfate through a vein in the emergency room can reduce sudden (non-injury) acute headaches compared with a placebo. It may help people whose headache comes on suddenly and is not caused by an injury.
MonastirAges 18–85 - NCT07725198Recruiting
Neck muscle responses after upper neck therapy
This trial looks at how a specific neck therapy affects a small muscle at the top of your neck. It may help researchers understand how hands-on treatment works for neck pain or stiffness.
Fort Myers, FloridaAges 18–65 - NCT07729449Recruiting
Predicting headache after cesarean using ultrasound and oxygen monitoring
This trial measures how well two monitoring tools (optic nerve ultrasound and brain oxygen levels) can predict headache after a planned cesarean. It may help find better ways to prevent post-dural puncture headache.
Ordu, AltinorduAges 18–40 - NCT07720765Recruiting
Using eye scans to study brain diseases
This trial uses a type of eye scan (OCT) to look at the retina in people with brain conditions like multiple sclerosis, Alzheimer's, Parkinson's, or migraines. It aims to see if these scans can help doctors learn more about the disease and monitor it over time.
Milan, MilanoAges 18 years+ - NCT07652034Recruiting
Tracking migraine relief after a minimally invasive artery procedure
This study follows adults who undergo a procedure called middle meningeal artery embolization—a minimally invasive treatment that blocks blood flow to a specific artery thought to trigger migraines. The trial simply tracks your symptoms and quality of life before and after the procedure to understand how well it works.
Tacoma, WashingtonAges 18–64 - NCT06684249Recruiting
Comparing nerve block and Botox for chronic migraine
This study compares two treatments for chronic migraine: a nerve block (injection near the nerves in the head) and Botox injections. It aims to see which one works better to reduce headache days and improve quality of life.
Zagazig, Sharqia ProvinceAges 18–65 - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Newark, DelawareAges 12 years+ - NCT07629635RecruitingPhase 3
Closing a heart hole to treat migraines
This trial tests whether closing a small hole in the heart (called a PFO) can help eliminate migraines. If you have frequent migraines and no other major health issues, this procedure might reduce or stop your headaches.
New York, New YorkAges 18–55 - NCT07629141Recruiting
Muscle Position and Dry Needling for Neck Pain
This study tests whether the position of your neck muscle affects how well dry needling (inserting thin needles into tight muscle knots) relieves chronic neck pain. Dry needling may help reduce pain by relaxing tense muscles.
Alcalá de Henares, MadridAges 18–80 - NCT07617441Recruiting
Brain and Psychology Study of Hard-to-Treat Migraines
This research study compares brain structure and psychological traits in people with chronic migraines that don't respond well to standard treatments versus healthy volunteers without migraines. Understanding these differences may help doctors develop better treatment options for difficult-to-treat migraines.
Catanzaro, CatanzaroAges 18–75 - NCT06711731Recruiting
Registry for spinal CSF leak and post-dural headache
This registry collects information from people with suspected spinal CSF leak (a condition where fluid leaks from around your spine) or headaches after a spinal procedure. By joining, you help researchers learn more about these conditions and improve future care.
Freiburg im BreisgauAges Any age - NCT07555873Recruiting
Osteopathic treatment versus physical therapy for neck and head dysfunction
This study compares two hands-on treatment approaches—osteopathic manipulation and physiotherapy—for chronic neck pain, headaches, and dizziness caused by cervical dysfunction. If you qualify, you'll receive one of these treatments and help researchers understand which works better.
Pristina, PejtonAges 18–65 - NCT07500558Recruiting
Ultrasound-guided nerve block for chronic migraine pain relief
This study tests two power levels of a pulsed radiofrequency treatment aimed at a nerve cluster behind your cheekbone to reduce chronic migraine pain. If you have frequent migraines that haven't responded well to two or more preventive medications, this could be an option for you.
MinyaAges 20–70 - NCT07476053Recruiting
How light exposure affects migraine and sleep
This study looks at how office lighting and sleep quality affect migraine. You'll track your headaches and light exposure. The goal is to find ways to improve sleep and reduce migraine attacks.
Tempe, ArizonaAges 18 years+ - NCT07454798Recruiting
Virtual reality neurofeedback for teens with migraine
This study tests whether using virtual reality neurofeedback can help teens with migraine. You would wear a VR headset and learn to control your brain's activity to reduce headache frequency.
Kansas City, MissouriAges 10–16
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Common questions
- Are there clinical trials for headache?
- Yes. Clin2 currently lists 164 recruiting headache studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a headache trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a headache trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.