Clinical trials
Heart Failure NYHA Class III clinical trials
Below are recruiting heart failure nyha class iii clinical trials, each written for real people, not researchers. We’re tracking 134 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05793996RecruitingPhase 4
Testing an iron infusion for iron deficiency in HFpEF
This study checks how common iron deficiency is in people with HFpEF (heart failure with preserved pumping strength) and tests whether an iron infusion (Ferinject®) improves health. It targets people with stable heart symptoms and lab results showing low iron stores or related iron deficiency.
TomskAges 18 years+ - NCT06053580RecruitingPhase 2
Valsartan for pulmonary hypertension: protection study
This trial tests whether a blood pressure medicine called valsartan can help protect the lungs and heart in people with a specific type of pulmonary hypertension (Group 1 PAH). If you have PAH and are stable enough to walk 50 meters, you may be able to join.
Seattle, WashingtonAges 18–80 - NCT06147336Recruiting
Testing the V-Lap system for heart failure monitoring
This trial tests a new device called V-Lap that is placed in the heart to monitor pressure. It may help doctors better manage heart failure and reduce hospital stays. Researchers want to see if it works well in people with mild to moderate heart failure.
Boston, MassachusettsAges 22–88 - NCT06229678RecruitingEarly Phase 1
Ketones and diabetes drug for heart failure with weak pump
This clinical trial looks at whether adding a special diet supplement (ketones) to an SGLT2 inhibitor diabetes drug improves heart function and symptoms in people who have both type 2 diabetes and heart failure with a weakened heart muscle.
San Antonio, TexasAges 18–70 - NCT06495970Recruiting
Pulmonary artery denervation for heart failure with lung hypertension
This trial tests a procedure called pulmonary artery denervation (PADN) for people with heart failure and a certain type of high blood pressure in the lungs (pulmonary hypertension Group 2). The goal is to see if using a special device called the Gradient Denervation System can help control the high pressures and improve your symptoms.
BadalonaAges 22–85 - NCT06561932Recruiting
Leadless pacemaker for heart failure resynchronization
This trial tests a completely leadless pacemaker (WiSE® CRT) for heart failure patients who need cardiac resynchronization therapy (CRT). It aims to avoid the long-term risks of traditional wires (leads) in the heart.
Birtinya, QueenslandAges 22 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT06876441Recruiting
Home Tai Chi Program for Heart Failure Patients and Caregivers
This study tests if a home-based Tai Chi program using a smartphone app can improve the health and well-being of people with chronic heart failure who are mostly sedentary. It also looks at how this program affects their caregivers, who will practice Tai Chi alongside them.
Qingdao, ShandongAges 18–75 - NCT07084142Recruiting
Digital aid for ICD decisions
This study is developing a digital tool to help people 70 and older with heart failure decide whether an ICD (a device that prevents dangerous heart rhythms) is right for them. Participants will help test and improve this tool.
San Francisco, CaliforniaAges 60 years+ - NCT07118488Recruiting
New ablation approach for persistent atrial fibrillation with heart issues
This study tests a new way to treat long-lasting atrial fibrillation using focused energy (pulse field ablation) guided by special heart mapping. It may help people who have not improved with medications or have other heart problems like heart failure.
Madrid, MadridAges 18–80 - NCT07516288RecruitingPhase 1
Second CAR-DC Cell Infusion for Advanced Heart Failure
This trial tests a second dose of specialized immune cells (called CAR-DC) in patients with severe dilated cardiomyopathy (a weakened heart muscle) who received one dose before but saw their heart function decline back to baseline. The goal is to see if a second dose is safe and can improve heart function when the first treatment's benefits wore off.
Hangzhou, Zhejiang / 浙江Ages 18–75 - NCT07643818Enrolling by invitationPhase 2
Iron Infusions for Heart Failure and Iron Deficiency
This trial tests whether intravenous iron infusions can help people with heart failure (preserved ejection fraction) who also have low iron levels. The goal is to improve symptoms, quality of life, and how far you can walk.
Saint HelierAges 18 years+ - NCT06697418Enrolling by invitation
Physical activity and heart health in peritoneal dialysis patients
This study uses a wrist-worn device to see how daily physical activity affects heart health and other outcomes for people on peritoneal dialysis. If you are on PD, can walk on your own, and are willing to wear a tracker, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05279742Enrolling by invitationPhase 1/Phase 2
Study drug to boost a hormone system in HFpEF
This early-phase trial tests a treatment that aims to improve the “natriuretic peptide” hormone system in people with HFpEF (heart failure with preserved pumping strength). It may help reduce symptoms and improve heart and fluid pressure behavior, especially in certain related conditions like kidney disease.
Rochester, MinnesotaAges 18 years+
Hear when a new Heart Failure NYHA Class III trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for heart failure nyha class iii?
- Yes. Clin2 currently lists 134 recruiting heart failure nyha class iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure nyha class iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure nyha class iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.