Clinical trials
Heart failure clinical trials
A condition where the heart can’t pump blood as well as it should. We’re tracking 949 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06907017Recruiting
CorWave left heart pump first-in-human study
This trial tests a new left ventricular assist device (LVAD) for people with advanced heart failure who are not responding to standard treatments and are eligible for a heart transplant. The pump helps the heart circulate blood.
Sydney, New South WalesAges 18–75 - NCT06905405Recruiting
Imaging for early heart failure with stiff heart muscle (HFpEF)
This study uses advanced imaging to find early signs of a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may help if you have shortness of breath and a slightly enlarged heart chamber but don't yet have a clear heart failure diagnosis.
Sheffield, South YorkshireAges 18 years+ - NCT06902896RecruitingPhase 1/Phase 2
FAP iCDC therapy for advanced heart failure from dilated cardiomyopathy
This trial tests a new treatment called FAP iCDC for people with end-stage dilated cardiomyopathy, a type of heart muscle disease. It aims to see if this therapy is safe and helps improve heart function when standard medicines are no longer enough.
Hangzhou, ZhejiangAges 18–75 - NCT06877169Recruiting
Staged heart and kidney transplant study
This study compares two ways of doing a combined heart and kidney transplant. It looks at doing the surgeries in separate stages instead of all at once, to see if that is safer or works better.
Los Angeles, CaliforniaAges 18 years+ - NCT06874556Recruiting
Paramedic support for heart failure management
This study tests if paramedics can help manage heart failure at home or in clinic, reducing hospital visits. It may be an option if you need frequent diuretic adjustments or early discharge with monitoring.
Rochester, MinnesotaAges 18 years+ - NCT06876441Recruiting
Home Tai Chi Program for Heart Failure Patients and Caregivers
This study tests if a home-based Tai Chi program using a smartphone app can improve the health and well-being of people with chronic heart failure who are mostly sedentary. It also looks at how this program affects their caregivers, who will practice Tai Chi alongside them.
Qingdao, ShandongAges 18–75 - NCT06872645Recruiting
Sodium-restricted diet for PD patients with high blood pressure
This study tests a new way to manage sodium (salt) for people on peritoneal dialysis. It aims to see if reducing sodium intake without water can help control blood pressure and improve health.
New Haven, ConnecticutAges 18 years+ - NCT06849752Recruiting
Early heart failure screening for high-risk patients
This trial checks for early signs of heart failure in people who have multiple risk factors. It will use blood tests, a wearable device, and a handheld ultrasound to find any changes early, so treatment can start quickly.
Cleveland, OhioAges 40 years+ - NCT05709132Recruiting
Peer mentorship program for teens living with heart failure
This program matches teens (ages 12–17) with a trained young adult mentor to exchange supportive check-ins by text or phone over about 15 weeks. It aims to help teen patients better manage their heart condition and feel supported through their care.
Toronto, OntarioAges 12–30 - NCT03951467Recruiting
Health literacy support to help you follow medical advice
This study tests whether a communication tool matched to your health literacy level can improve how well people follow medical recommendations after an acute episode. It may help you understand your care plan and take the right next steps at home.
BronAges 18 years+ - NCT06812533Recruiting
Testing a new approach for heart failure with weak pump
This study tests a new device or procedure to help people with heart failure and a weak heart pump. If you have a low ejection fraction and are on standard medications, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06793371RecruitingPhase 2
Study of CK-4021586 for heart failure with preserved ejection fraction
This trial tests an investigational drug called CK-4021586 for people with heart failure with preserved ejection fraction (HFpEF). It aims to see if the drug is safe and well-tolerated. You may qualify if you are 40 to 85, have heart failure symptoms, and have a heart that pumps well but shows signs of strain.
Fairhope, AlabamaAges 40–85 - NCT06384963Recruiting
Pacing after bypass for heart failure patients
This trial tests a special pacing therapy that uses your natural breathing rhythm to improve heart function after coronary artery bypass surgery. It may help people with weak heart muscles recover better after surgery.
Adelaide, South AustraliaAges 22 years+ - NCT06779552Recruiting
Study of CardioMEMS System for Heart Failure Patients
This study is looking at how well the CardioMEMS heart monitor works for people with heart failure. The device is already implanted and tracks pressure in your lung artery to help your doctor manage your condition and potentially prevent hospital visits.
Pleasanton, CaliforniaAges 18 years+ - NCT06765226Recruiting
Study of used Impella heart pumps
This study looks at used Impella heart pumps to see what deposits build up on them during treatment. If you've had an Impella pump for a certain length of time, this study helps doctors learn more about the device.
Heidelberg, Baden-WurttembergAges 18 years+ - NCT06770023RecruitingPhase 1
Bridge to lung transplant with ECMO for right heart failure
This study tests a special heart-lung support machine (ECMO) for people waiting for a lung transplant whose heart is failing due to high blood pressure in the lungs. The machine helps rest the heart and lungs until transplant surgery.
Jacksonville, FloridaAges 18–80 - NCT06741436Recruiting
Exercise testing after preeclampsia
This study looks at how the heart and blood vessels work after a pregnancy complicated by preeclampsia. It uses exercise testing to see if there are lasting effects, which may help improve long-term heart health monitoring and care.
Nashville, TennesseeAges 18 years+ - NCT06747429Recruiting
High-fat diet for heart failure metabolism
This trial tests whether a high-fat diet can help change how your heart uses energy, potentially improving heart function in people with non-ischemic heart failure.
ParisAges 18 years+ - NCT06495970Recruiting
Pulmonary artery denervation for heart failure with lung hypertension
This trial tests a procedure called pulmonary artery denervation (PADN) for people with heart failure and a certain type of high blood pressure in the lungs (pulmonary hypertension Group 2). The goal is to see if using a special device called the Gradient Denervation System can help control the high pressures and improve your symptoms.
BadalonaAges 22–85 - NCT06309550Recruiting
Testing for heart failure with preserved ejection fraction
This trial uses special tests to see if you have a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It's for people who feel short of breath but haven't been diagnosed with this condition yet.
MilanAges Any age - NCT05564793Recruiting
Noninvasive heart mapping to improve CRT outcomes
This trial tests whether a special noninvasive heart “mapping” test done on the body can help improve outcomes for people who need a CRT device. It studies whether mapping before implantation can better guide or predict how well the CRT will work.
AmsterdamAges 18–85 - NCT06697418Enrolling by invitation
Physical activity and heart health in peritoneal dialysis patients
This study uses a wrist-worn device to see how daily physical activity affects heart health and other outcomes for people on peritoneal dialysis. If you are on PD, can walk on your own, and are willing to wear a tracker, you may be able to join.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06689111Recruiting
Heart resynchronization method study for patients with LBBB and heart failure
This study compares two ways to resynchronize the heart's pumping in people with heart failure and a specific heart block (LBBB). It uses special ultrasound imaging to see which method works better for improving heart function.
Pátrai, GreeceAges 18–90 - NCT06161987Recruiting
Early rehab for acute heart failure
This study tests whether starting a tailored exercise and education program early in the hospital can help people with acute heart failure recover faster and feel better. It includes walking, breathing exercises, and support to get you back to daily activities.
Guangzhou, GuangdongAges 18–80
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Common questions
- Are there clinical trials for heart failure?
- Yes. Clin2 currently lists 949 recruiting heart failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.