Clinical trials
Heart Transplant clinical trials
Below are recruiting heart transplant clinical trials, each written for real people, not researchers. We’re tracking 92 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04924491RecruitingPhase 1/Phase 2
Treg cell therapy to help prevent rejection after child heart transplant
This early-phase study tests a cell treatment (Treg cells made from a child’s thymus tissue) to help prevent the body from rejecting a new heart. It may help reduce rejection risk, but it is experimental and involves added risks and follow-up.
Madrid, MadridAges Up to 2 years - NCT06625073RecruitingPhase 4
SGLT2i for heart transplant recipients
This trial is testing a medication called SGLT2i (a type of diabetes drug that also helps the heart and kidneys) in people who have received a heart transplant. It aims to see if this drug can improve health after transplant.
Palo Alto, CaliforniaAges 18 years+ - NCT07195032RecruitingPhase 4
MMR vaccine safety in kids after heart transplant
This trial tests whether the MMR (measles, mumps, rubella) vaccine is safe and works well for children who have had a heart transplant. It may help protect you from these diseases if you haven't had the vaccine or no longer have immunity.
Kansas City, MissouriAges 1–17 - NCT06795958Recruiting
Detecting heart rejection without a biopsy in children
This trial tests if a special MRI can detect early signs of heart rejection in children and young adults who have had a heart transplant. If successful, it might reduce the need for invasive biopsies.
BolognaAges Up to 18 years - NCT06032195RecruitingPhase 2
Study of heart preservation in children needing a first transplant
This study looks at how the heart muscle is kept healthy after donation and before transplant in children. It aims to improve transplant success.
BerlinAges 1 day–17 years - NCT06190171Recruiting
Breathing strength training for heart transplant patients
This trial tests whether a special breathing and muscle-strengthening exercise program can help people waiting for a heart transplant. It is designed to improve your respiratory strength and overall conditioning before surgery.
Nashville, TennesseeAges 18–90 - NCT06341543Recruiting
CMV blood test to guide treatment after organ transplant
This study uses a blood test (QuantiFERON-CMV) to help decide whether people with a silent (no symptoms) CMV infection after a solid organ transplant need treatment. If you have a low-to-moderate level of CMV in your blood without fever or organ issues, this trial may help your doctor choose the safest approach.
Grenoble, MarylandAges 18 years+ - NCT06986980Recruiting
Gut Infection After Heart Transplant Study
This study looks at a rare gut infection (microsporidiosis) in people who have had a heart transplant. If you had this infection before 2025 and the diagnosis was made in France, your medical records may be reviewed to learn more about the infection.
Clermont-FerrandAges Any age - NCT06982404Recruiting
Heart transplant biopsy study
This study tests whether a small biopsy taken from a donor heart before transplant can predict how well the heart will work after surgery. The goal is to improve transplant success for recipients.
Vienna, State of ViennaAges Any age - NCT07145515Recruiting
Heart preservation device trial for transplant patients
This trial tests a portable device that keeps donor hearts healthy outside the body before transplant. It may help more donor hearts be used, including those from donors after circulatory death and hearts previously considered less suitable.
San Francisco, CaliforniaAges 18 years+ - NCT05451979Recruiting
Exercise training at home for kids after heart transplant
This trial tests a home-based, short bursts exercise program (HIIT using the MedBIKE™ system) for children who had a heart transplant at least 6 months ago. It may help improve fitness and safety after transplant, while checking which kids can participate without heart rhythm or symptom problems.
Edmonton, AlbertaAges 10–18 - NCT06659952Recruiting
HIV+ donor hearts for HIV+ recipients
This trial tests whether hearts from donors who had HIV can be safely transplanted into people with HIV who need a heart transplant. It may offer a new option for those on the waiting list.
Dallas, TexasAges 18 years+ - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Los Angeles, CaliforniaAges Up to 21 years - NCT05915299Recruiting
Heart surgery donor heart monitoring registry
This is a registry that collects information about how donated hearts are handled using a portable machine that keeps the heart healthy outside the body. It may help researchers improve future care, but it usually does not test a new medication.
Phoenix, ArizonaAges Any age - NCT05775432Recruiting
Study outcomes for people receiving heart transplants
This study follows people with severe (end-stage) heart failure who are evaluated for and receive a heart transplant. It helps doctors understand what outcomes to expect after transplant, which can guide future care.
Xi'an, ShaanxiAges 3–80 - NCT06868797Recruiting
Dapagliflozin for advanced heart failure patients waiting for transplant
This study tests whether dapagliflozin (a medicine already approved for other heart conditions) can help protect kidney and heart function in people with very advanced heart failure who are waiting for a heart transplant. If you qualify, you'll help researchers learn if this drug offers extra benefits beyond standard care.
BronAges 18 years+ - NCT01733082Recruiting
Mycophenolate pregnancy registry for mothers in the U.S.
This study collects information about pregnancies where a mother took mycophenolate during pregnancy (or stopped within the prior 6 weeks). It aims to better understand pregnancy outcomes and risks so care can be improved for future patients.
Cambridge, MassachusettsAges Any age - NCT05025774Recruiting
Exercise program study for young heart, leukemia, and lung survivors
This study looks at how an exercise program affects fitness and lung function in young people who are survivors of certain conditions (heart transplant, leukemia, or lung disease from prematurity). The goal is to see whether exercise can improve breathing and overall physical function safely.
Minneapolis, MinnesotaAges 8–25 - NCT06325280Recruiting
Exercise MRI for Kids with Heart Conditions
This study uses an MRI while exercising to check heart and lung fitness in children with heart disease. It helps doctors learn more about how to care for kids who have had a heart transplant or were born with heart problems.
Edmonton, AlbertaAges 10–18 - NCT06387446Recruiting
Donated heart valve transplant for children and young adults
This study is testing a new way to replace a damaged heart valve using a donated valve (allograft) that may last longer and work better for children and young adults. It may be a good option if you need a new valve and have few other choices.
Boston, MassachusettsAges 4 weeks–50 years - NCT03292861Enrolling by invitationPhase 2
Thymoglobulin after first heart transplant: safety and effect
This trial tests whether Thymoglobulin® is safe and how well it works in people getting their first heart transplant. It may help doctors fine-tune medicines used to prevent the body from rejecting the new heart.
Los Angeles, CaliforniaAges 18–70 - NCT05994274Recruiting
Heart transplant, cholesterol, and organ rejection study
This study looks at whether changes in blood fats (cholesterol and triglycerides) after a heart transplant are linked to the risk of organ rejection. It may help doctors better monitor and protect your new heart.
WuhanAges 18 years+ - NCT07673536Recruiting
Heart transplant monitoring with extracellular vesicles
This study uses tiny particles called extracellular vesicles (which cells release) to check for signs of organ rejection after a heart transplant, aiming for a safer and less invasive alternative to biopsies.
Berlin, State of BerlinAges 18 years+ - NCT06464016Recruiting
Infections in Kids With Berlin Heart Pumps
This study looks at infections in children who used a Berlin Heart mechanical heart pump. It aims to find better ways to prevent and treat these infections.
LyonAges 1 day–18 years
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Common questions
- Are there clinical trials for heart transplant?
- Yes. Clin2 currently lists 92 recruiting heart transplant studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a heart transplant trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a heart transplant trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.