Clinical trials · Ohio
Heart Valve Diseases clinical trials in Ohio
We’re tracking 30 recruiting heart valve diseases studies with a site in Ohio — including Phase 2 studies, each written for real people, not researchers.
Recruiting studies in Ohio
- NCT07214376Recruiting
Nerve ablation for pulmonary hypertension from left heart disease
This trial tests a device that uses a catheter to deliver energy to nerves around the pulmonary arteries, aiming to reduce high blood pressure in the lungs caused by left heart failure. It is for people with ongoing heart failure symptoms despite optimal medications.
Cleveland, OhioAges 18–85 - NCT06310031Recruiting
Testing BrioVAD heart pump for severe heart failure
This trial tests a new left-ventricular assist device (LVAD) called BrioVAD for people with advanced heart failure who are not getting enough benefit from medicines. If you qualify, the device is implanted to help your heart pump blood.
Cincinnati, OhioAges 18–100 - NCT06506942Recruiting
TRICURE device study for leaky heart valve
This study tests a new device to help people with severe tricuspid regurgitation (leaky heart valve) who are at higher risk from surgery. It aims to see if the device can reduce the leak and improve symptoms.
Cincinnati, OhioAges 18 years+ - NCT04073420Recruiting
Cardiac surgery registry to track Medtronic device outcomes
This registry collects real-world information from people who have had—or plan to have—an eligible Medtronic cardiac surgery device. It aims to better understand how these treatments do over time and help guide future care.
Cleveland, OhioAges Any age - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT05913908Recruiting
Valve procedure study for severe tricuspid leakage
This trial tests how well a new catheter-based valve system works for people with severe (or worse) tricuspid valve leaking who still have symptoms despite medicines. It aims to improve outcomes by treating the leaking valve without open-heart surgery, if your heart structure and overall health fit the study.
Columbus, OhioAges 18 years+ - NCT06027788Recruiting
Embolic protection during heart valve surgery
This trial tests a device that may help protect your brain from small particles during heart valve surgery. It is for people 60 and older having certain types of valve replacement or repair.
Cleveland, OhioAges 60 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Cleveland, OhioAges 18 years+ - NCT06917586Recruiting
Mosaic mitral valve study for patients under 65
This study looks at long-term results in people under 65 who received a specific type of replacement heart valve (the Mosaic mitral valve) during surgery at ProMedica Toledo Hospital. It aims to understand how well the valve works over time.
Toledo, OhioAges 18–65 - NCT07069673Recruiting
Abbott Cephea mitral valve disease registry
This study tracks people with mitral valve disease who receive the Cephea valve through a tube in an artery rather than open-heart surgery. It looks at how well the valve works over time.
Cleveland, OhioAges 18 years+ - NCT03142152Recruiting
Mitral valve implant for heart failure with leaky mitral valve
This trial tests whether a device called the Carillon Mitral Contour System can help people with heart failure caused by a mild-to-moderate leaky mitral valve. You’d be compared against a control group, and the goal is to improve heart failure symptoms and outcomes.
Cleveland, OhioAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Cincinnati, OhioAges 18 years+ - NCT07466745Recruiting
New Pulmonary Valve Study for Kids Needing Replacement
This study tests a new type of replacement valve for children who need a new pulmonary valve (the valve between the heart and lungs). Researchers want to see if the valve works safely and well in real-world use.
Columbus, OhioAges 1.5 years–16 years - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
Columbus, OhioAges 5 months–7 months - NCT06818760Recruiting
Remote monitoring for pregnant women with heart conditions
This study tests if a wrist wearable can safely monitor pregnant women with congenital heart disease. It aims to improve care during pregnancy, delivery, and after birth by tracking health data remotely.
Cleveland, OhioAges 18 years+ - NCT02744677Recruiting
Pulmonary valve procedure to improve blood flow issues
This trial studies a transcatheter pulmonary valve (a valve placed through a catheter) in people whose right-sided outflow tract valve/conduit is not working well. It aims to improve blood flow and reduce pressure problems, while checking safety and results after the procedure.
Cincinnati, OhioAges Any age - NCT04467671RecruitingPhase 2
Tested new blood vessel graft for a heart surgery
This trial studies whether a newer “tissue-engineered” blood vessel graft is safe and works well in children who need a specific heart surgery connection outside the heart. It may help by offering a new type of graft, but your team will screen for size and medical factors first.
Columbus, OhioAges Any age - NCT06455787Recruiting
J-Valve study for leaky aortic valve patients
This study tests a new, less invasive device called J-Valve for people with severe aortic regurgitation (a leaky aortic valve). It is placed through a tube in the leg artery, avoiding open-heart surgery, and may help those who are at high risk for surgery.
Cincinnati, OhioAges 18 years+ - NCT07449325Recruiting
Heart sinus reducer for chest pain from small vessel disease
This trial tests a device placed in a heart vein (the coronary sinus) to improve blood flow and reduce chest pain in people with coronary microvascular dysfunction (small blood vessel disease). It aims to help those who still have symptoms despite taking heart medications.
Cincinnati, OhioAges 18 years+ - NCT05610787Enrolling by invitation
Testing a device that helps move an EXCOR pediatric heart pump
This trial studies an “active driving” system that controls the EXCOR pediatric heart pump. It’s meant for children who need a heart pump as a bridge to heart transplantation, to help the pump work more safely and effectively.
Cincinnati, OhioAges Up to 21 years - NCT06003023Recruiting
Physical activity study for teens with congenital heart disease
This study looks at how teens and young adults with moderate to complex congenital heart disease can improve their physical activity. You might be eligible if you're between 15 and 25, have a heart condition, and get care at Nationwide Children's Hospital or Ohio State University.
Columbus, OhioAges 15–25 - NCT04451044Enrolling by invitation
Guided heart stent planning using an inside pressure sensor
This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.
Akron, OhioAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Cincinnati, OhioAges Any age - NCT04097145Recruiting
Heart valve repair for severe leaking tricuspid valve
This trial tests a catheter-based procedure (done through the blood vessels) to repair a severely leaky tricuspid valve. It may help people with symptoms or past hospitalizations from tricuspid valve leakage who are higher-risk for standard surgery.
Cincinnati, OhioAges 18 years+
Heart Valve Diseases trials by city in Ohio
Where these studies are running in Ohio
Institutions with a site for the recruiting heart valve diseases studies listed above.
- Cleveland Clinic · 12 studies
- The Christ Hospital · 10 studies
- Nationwide Children's Hospital · 5 studies
- University Hospitals Cleveland Medical Center · 3 studies
- Cincinnati Children's Hospital Medical Center · 2 studies
- Ohio Health Research Institute · 2 studies
- The Ohio State University Wexner Medical Center · 2 studies
- Kettering Health
What taking part in a heart valve diseases study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Heart Valve Diseases trials in other states
Common questions
- Are there heart valve diseases clinical trials in Ohio?
- Yes. We're currently tracking 30 recruiting heart valve diseases studies with a site in Ohio, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a heart valve diseases study in Ohio?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Ohio to take part?
- Not necessarily. These studies have a site in Ohio, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a heart valve diseases trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New heart valve diseases studies open in Ohio regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.